CAJ | 학술논문

细胞自噬作为细胞程序性死亡的一种类型,与肿瘤的发生发展密切相关.本文根据近年来细胞自噬在肝细胞癌中的研究成果,首先说明了细胞自噬的定义和机制,着重总结了细胞自噬在肝细胞癌发生中的作用,对化疗、放疗的疗效影响以及针对细胞自噬的新药研发成果,并重点分析了细胞自噬作用的两重性.
세포자서작위세포정서성사망적일충류형,여종류적발생발전밀절상관.본문근거근년래세포자서재간세포암중적연구성과,수선설명료세포자서적정의화궤제,착중총결료세포자서재간세포암발생중적작용,대화료、방료적료효영향이급침대세포자서적신약연발성과,병중점분석료세포자서작용적량중성.
This review discusses the relationship between autophagy and hepatocellular carcinoma (HCC).It will focus on the definition and mechanism of autophagy,the effects of autophagy on carcinogenesis,the reaction that chemotherapy and radiotherapy have on autophagy,developments of novel therapeutic methods aimed at autophagy,and will emphasize the bipolar role of autophagy in HCC.