CAJ | 학술논문

胰腺癌是恶性程度极高的肿瘤.探究胰腺癌浸润、转移的发生发展机制,对于提高治疗效果具有重要意义.在多种恶性肿瘤中,肿瘤相关巨噬细胞(TAM)具有促进肿瘤进展和侵袭的作用.在间质成分居多的胰腺癌微环境中,TAM具有重要作用.研究TAM与胰腺癌发生发展的相关机制以及TAM不同表型间的相互转化,可能为胰腺癌的治疗带来新的突破.
이선암시악성정도겁고적종류.탐구이선암침윤、전이적발생발전궤제,대우제고치료효과구유중요의의.재다충악성종류중,종류상관거서세포(TAM)구유촉진종류진전화침습적작용.재간질성분거다적이선암미배경중,TAM구유중요작용.연구TAM여이선암발생발전적상관궤제이급TAM불동표형간적상호전화,가능위이선암적치료대래신적돌파.
Pancreatic cancer is a highly malignant tumor.It is of great importance to improve the effectiveness of treatment by studying the mechanisms which lead to invasion and metastasis in pancreatic cancer.In some malignant tumors,tumor associated macrophage (TAM) plays an important role in tumor progression and invasion.TAM also plays an important role in pancreatic cancer which consists mainly of stromal elements.Research into the mechanisms for occurrence and development of pancreatic cancer,the role played by TAM as well as TAM transformation between the different phenotypes may bring a breakthrough in the treatment of pancreatic cancer.