CAJ | 학술논문

目的通过CT、MRI及组织学分析,探讨腰椎间盘后方高信号区(high-intensity zone,HIZ)的病理学性质.方法选取下腰痛患者中其MRI T2加权像存在局限性HIZ患者41例,男23例,女18例;年龄33～50岁,平均年龄38岁.按照MRI T1加权像HIZ的特点分为两组,T1加权非高信号组(29例)即T2加权像呈高信号,T1加权像呈低或等信号;T1加权高信号组(12例)即T1、T2加权像均呈高信号.所有病例均同时进行X线和CT检查,T1加权非高信号组中26例进行了椎间盘造影以及疼痛激发试验.T1加权非高信号组15例、T1加权高信号组7例接受了手术治疗,手术方式分别为经椎间孔椎体间融合术或后路椎体间减压融合术,并对术中切取的HIZ区域标本进行HE染色和(或)免疫组织化学染色进行观察.结果 T1加权非高信号组患者X线、CT及MR检查均显示椎间盘退变,26例进行椎间盘造影以及疼痛激发试验者中21例造影阳性及疼痛复制,并显示纤维环破裂,其中15例阳性者接受手术治疗;5例阴性.术中切取的HIZ区域标本HE染色显示为纤维环破裂伴随肉芽组织长入,CD34染色可见HIZ区域内新生毛细血管,CD68见HIZ区域内多量染色阳性的巨噬细胞,而HIZ外区域表达较弱.而T1加权高信号组患者椎间盘在CT上显示为后方纤维环钙化或骨化,HE染色可见明显的钙化灶和钙化的潮汐线形成.结论腰椎间盘后方HIZ,在T2加权像的局限性高信号、T1加权像呈局限性较低或等信号意味着通常所指的纤维环破裂伴随肉芽组织长入;而T2、T1加权像均呈高信号可能是钙化或骨化灶,因此,传统HIZ的概念可能需要进行一定的修正,结合CT检查可能更有意义.
목적 통과CT、MRI급조직학분석,탐토요추간반후방고신호구(high-intensity zone,HIZ)적병이학성질.방법 선취하요통환자중기MRI T2가권상존재국한성HIZ환자41례,남23례,녀18례;년령33～50세,평균년령38세.안조MRI T1가권상HIZ적특점분위량조,T1가권비고신호조(29례)즉T2가권상정고신호,T1가권상정저혹등신호;T1가권고신호조(12례)즉T1、T2가권상균정고신호.소유병례균동시진행X선화CT검사,T1가권비고신호조중26례진행료추간반조영이급동통격발시험.T1가권비고신호조15례、T1가권고신호조7례접수료수술치료,수술방식분별위경추간공추체간융합술혹후로추체간감압융합술,병대술중절취적HIZ구역표본진행HE염색화(혹)면역조직화학염색진행관찰.결과 T1가권비고신호조환자X선、CT급MR검사균현시추간반퇴변,26례진행추간반조영이급동통격발시험자중21례조영양성급동통복제,병현시섬유배파렬,기중15례양성자접수수술치료;5례음성.술중절취적HIZ구역표본HE염색현시위섬유배파렬반수육아조직장입,CD34염색가견HIZ구역내신생모세혈관,CD68견HIZ구역내다량염색양성적거서세포,이HIZ외구역표체교약.이T1가권고신호조환자추간반재CT상현시위후방섬유배개화혹골화,HE염색가견명현적개화조화개화적조석선형성.결론 요추간반후방HIZ,재T2가권상적국한성고신호、T1가권상정국한성교저혹등신호의미착통상소지적섬유배파렬반수육아조직장입;이T2、T1가권상균정고신호가능시개화혹골화조,인차,전통HIZ적개념가능수요진행일정적수정,결합CT검사가능경유의의.
Objective To explore the possible pathological essence of HIZ in lumbar intervertebral disc by means of CT,MRI and histomorphology analysis.Methods All of 41 patients of low back pain with the HIZ in the lumbar disc on MRI were identified.There is 23 males and 18 females with mean age of 38 years (range 33-50 years).All the patients were divided into 2 groups according to the characteristics of HIZ on MRI:group A,29 patients with high intensity on MRI T2WI and low intensity on MRI T1WI; group B,12 patients with high intensity both on T2WI and T1WI.All these patients underwent X-rays and CT scan on the targeted level.26 patients in group A were performed discography and pain provocative test.15 patients in group A and 7 patients in group B underwent operation and those samples of HIZ region were excised for HE staining and immunohistochemical analysis.Results All the patients in group A were proved intervertebral disc degeneration on CT and MRI.21 patients in 26 who underwent discography and pain provocative test were proved positive and 15 of them underwent operation(Transforaminal lumbar interbody fusion or posterior lumbar interbody fusion).Histomorphology examination showed annular tear combined with granulation tissue in the samples of HIZ region which were excised in operation.Neoformative blood capillary could be seen through CD34 staining.Macrophage could be found in CD68 staining,but the regions off the HIZ were less stained.In group B,all those targeted discs showed calcified or ossified lesion on the posterior annular on CT scan,HE staining showed calcification or ossification of the posterior annulus fibrosus with frontier line.Conclusion The HIZ on MRI T2WI with low intensity zone on T1WI possibly refers to annular tear combined with granulation in-growth.But the HIZ both on MRI T2WI and T1WI might be calcification or ossification.The conventional concept of HIZ might be modified as HIZ on MRI T2WI,but low intensity zone on MRI T1WI.In addition,CT scan might be helpful in the distinguished diagnosis.