中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2012年
11期
843-847
,共5页
李臻%李娅%李腾飞%周进学%韩新巍%陈清亮%任建庄%袁慧峰
李臻%李婭%李騰飛%週進學%韓新巍%陳清亮%任建莊%袁慧峰
리진%리아%리등비%주진학%한신외%진청량%임건장%원혜봉
黄疸,阻塞性%胆道金属支架%放射摄影术,介入性
黃疸,阻塞性%膽道金屬支架%放射攝影術,介入性
황달,조새성%담도금속지가%방사섭영술,개입성
Jaundice,obstructive%Biliary metallic stent%Radiology,interventional
目的 探讨胆道金属支架治疗恶性阻塞性黄疸(MOJ)的临床疗效. 方法 回顾性分析1998年2月至2009年2月的241例MOJ患者临床资料,所有患者均接受经皮肝穿刺胆道金属支架置入术.评价预后以死亡为研究终点,随访时间截至2010年2月,统计学分析比较患者生存期及治疗前后各实验室指标改变,评价疗效.计数资料采用x2检验,计量资料用t检验;生存率比较采用Kaplan-Meier法;Cox回归模型评估各危险因素对生存时间的影响. 结果 支架置入技术成功率为100%.支架置入术后4周内血清胆红素下降明显(P< 0.05),术后院内死亡11例,失访28例,202例获得完整随访资料;随访时间为8~ 193周,其13周、26周、39周、52周的生存率分别为87%、66%、56%、41%,中位生存期为43.55周.同期支架通畅率分别为70%、46%、36%和24%,平均通畅时间为27.57周.Cox回归分析示:术前胆红素< 221 μmol/L(P=0.01)及术后胆红素下降比例超过50%(P=0.002)者预后较好.结论 胆道金属支架置入术治疗MOJ技术安全、可行,可有效缓解黄疸症状,延长生存期.高胆红素血症及胆红素下降程度低于50%是影响MOJ患者生存率的因素.
目的 探討膽道金屬支架治療噁性阻塞性黃疸(MOJ)的臨床療效. 方法 迴顧性分析1998年2月至2009年2月的241例MOJ患者臨床資料,所有患者均接受經皮肝穿刺膽道金屬支架置入術.評價預後以死亡為研究終點,隨訪時間截至2010年2月,統計學分析比較患者生存期及治療前後各實驗室指標改變,評價療效.計數資料採用x2檢驗,計量資料用t檢驗;生存率比較採用Kaplan-Meier法;Cox迴歸模型評估各危險因素對生存時間的影響. 結果 支架置入技術成功率為100%.支架置入術後4週內血清膽紅素下降明顯(P< 0.05),術後院內死亡11例,失訪28例,202例穫得完整隨訪資料;隨訪時間為8~ 193週,其13週、26週、39週、52週的生存率分彆為87%、66%、56%、41%,中位生存期為43.55週.同期支架通暢率分彆為70%、46%、36%和24%,平均通暢時間為27.57週.Cox迴歸分析示:術前膽紅素< 221 μmol/L(P=0.01)及術後膽紅素下降比例超過50%(P=0.002)者預後較好.結論 膽道金屬支架置入術治療MOJ技術安全、可行,可有效緩解黃疸癥狀,延長生存期.高膽紅素血癥及膽紅素下降程度低于50%是影響MOJ患者生存率的因素.
목적 탐토담도금속지가치료악성조새성황달(MOJ)적림상료효. 방법 회고성분석1998년2월지2009년2월적241례MOJ환자림상자료,소유환자균접수경피간천자담도금속지가치입술.평개예후이사망위연구종점,수방시간절지2010년2월,통계학분석비교환자생존기급치료전후각실험실지표개변,평개료효.계수자료채용x2검험,계량자료용t검험;생존솔비교채용Kaplan-Meier법;Cox회귀모형평고각위험인소대생존시간적영향. 결과 지가치입기술성공솔위100%.지가치입술후4주내혈청담홍소하강명현(P< 0.05),술후원내사망11례,실방28례,202례획득완정수방자료;수방시간위8~ 193주,기13주、26주、39주、52주적생존솔분별위87%、66%、56%、41%,중위생존기위43.55주.동기지가통창솔분별위70%、46%、36%화24%,평균통창시간위27.57주.Cox회귀분석시:술전담홍소< 221 μmol/L(P=0.01)급술후담홍소하강비례초과50%(P=0.002)자예후교호.결론 담도금속지가치입술치료MOJ기술안전、가행,가유효완해황달증상,연장생존기.고담홍소혈증급담홍소하강정도저우50%시영향MOJ환자생존솔적인소.
Objective To evaluate the clinical efficacy of implanted biliary metallic stents in the management of malignant obstructive jaundice (MOJ).Methods Percutaneous transhepatic cholangiography and stent insertion were performed in 241 consecutive patients to treat malignant biliary obstruction between December 1998 and February 2009.The study end point was patient death.All patients were followed-up until death or until February 2010.The therapeutic efficacy was determined by statistical analysis of life span and pre-and post-operative laboratory indices.Results All 241 patients were successfully stented.The level of bilirubin descended obviously within four weeks of implantation (P < 0.05),and the early mortality rate was 4.56% (11/241).Two-hundred-and-two patients were followed-up (range:8-193 weeks posttransplantation) and showed a median survival of 43.55 weeks.The survival rates at 13,26,39 and 52 weeks post-transplantation were 87%,66%,56%,and 41%,respectively.The stent patency rates at 13,26,39 and 52 weeks post-transplantation were 70%,46%,36% and 24%,respectively; the mean stent patency was 27.57weeks.Cox regression analysis identified the strong predictors of improved survival as an initial bilirubin level of <221 μmol/L (P =0.01) and a stent-induced bilirubin reduction of >50% (P =0.002).Conclusion Transhepatic metallic biliary stenting is a safe and effective therapeutic intervention for malignant biliary obstruction.Significant periods of survival and palliation of jaundice can be achieved with this method.Hyperbilirubinemia and a stent-induced bilirubin reduction of <50% are independent predictive factors for the survival of MOJ patients.