中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2013年
1期
62-65
,共4页
郑瑞丹%庄群瑛%陈建能%陈洁%卢燕辉
鄭瑞丹%莊群瑛%陳建能%陳潔%盧燕輝
정서단%장군영%진건능%진길%로연휘
脂肪肝%危险因素%男性%人体质量指数%腰围
脂肪肝%危險因素%男性%人體質量指數%腰圍
지방간%위험인소%남성%인체질량지수%요위
Fatty liver%Risk factors%Men%Body mass index%Waist circumference
目的 探讨男性非酒精性脂肪性肝病(NAFLD)的危险因素,为NAFLD的防治提供理论依据. 方法 研究对象为厦门大学附属东南医院肝病中心住院的102例男性NAFLD患者为NAFLD组,选取同期健康体检正常的23例男性为对照组,采用单因素和多因素logistic回归分析方法,比较两组人体质量指数(BMI)、腰围(WC)、腰臀比(WHR)、空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)与男性NAFLD的相关性,绘制受试者工作特征曲线(ROC曲线),以寻找判别临界点.用SPSS13.0软件进行统计学处理,组间对比用成组t检验.危险因素分析采用单因素和多因素logistic回归分析.结果 BMI、WC、WHR、FPG、TG、TC,NAFLD组分别为(26.85±3.88)kg/m2、(91.2±7.0) cm、0.92±0.04、(5.37±1.43) mmol/L、(2.29±1.83) mmol/L和(5.10±1.26) mmol/L；对照组分别为(20.73±2.65) kg/m2、(81.6±7.4) cm、0.86±0.05、(5.01±2.66) mmol/L、(1.25±0.94) mmol/L和(4.24±1.63) mmol/L；t值分别是-6.442、5.895、7.452、-3.634、-4.114和2.624,P值均＜0.01,差异均有统计学意义.BMI、WC、WHR、TG、TC均为男性NAFLD的危险因素(P＜0.01),BMI在预测男性NAFLD发生上最有价值(OR=10.819),WHR次之(OR=10.588). 结论 BMI、WC、WHR、TG、TC是男性NAFLD的危险因素,BMI、WHR预测男性NAFLD的价值最高.
目的 探討男性非酒精性脂肪性肝病(NAFLD)的危險因素,為NAFLD的防治提供理論依據. 方法 研究對象為廈門大學附屬東南醫院肝病中心住院的102例男性NAFLD患者為NAFLD組,選取同期健康體檢正常的23例男性為對照組,採用單因素和多因素logistic迴歸分析方法,比較兩組人體質量指數(BMI)、腰圍(WC)、腰臀比(WHR)、空腹血糖(FPG)、甘油三酯(TG)、總膽固醇(TC)與男性NAFLD的相關性,繪製受試者工作特徵麯線(ROC麯線),以尋找判彆臨界點.用SPSS13.0軟件進行統計學處理,組間對比用成組t檢驗.危險因素分析採用單因素和多因素logistic迴歸分析.結果 BMI、WC、WHR、FPG、TG、TC,NAFLD組分彆為(26.85±3.88)kg/m2、(91.2±7.0) cm、0.92±0.04、(5.37±1.43) mmol/L、(2.29±1.83) mmol/L和(5.10±1.26) mmol/L；對照組分彆為(20.73±2.65) kg/m2、(81.6±7.4) cm、0.86±0.05、(5.01±2.66) mmol/L、(1.25±0.94) mmol/L和(4.24±1.63) mmol/L；t值分彆是-6.442、5.895、7.452、-3.634、-4.114和2.624,P值均＜0.01,差異均有統計學意義.BMI、WC、WHR、TG、TC均為男性NAFLD的危險因素(P＜0.01),BMI在預測男性NAFLD髮生上最有價值(OR=10.819),WHR次之(OR=10.588). 結論 BMI、WC、WHR、TG、TC是男性NAFLD的危險因素,BMI、WHR預測男性NAFLD的價值最高.
목적 탐토남성비주정성지방성간병(NAFLD)적위험인소,위NAFLD적방치제공이론의거. 방법 연구대상위하문대학부속동남의원간병중심주원적102례남성NAFLD환자위NAFLD조,선취동기건강체검정상적23례남성위대조조,채용단인소화다인소logistic회귀분석방법,비교량조인체질량지수(BMI)、요위(WC)、요둔비(WHR)、공복혈당(FPG)、감유삼지(TG)、총담고순(TC)여남성NAFLD적상관성,회제수시자공작특정곡선(ROC곡선),이심조판별림계점.용SPSS13.0연건진행통계학처리,조간대비용성조t검험.위험인소분석채용단인소화다인소logistic회귀분석.결과 BMI、WC、WHR、FPG、TG、TC,NAFLD조분별위(26.85±3.88)kg/m2、(91.2±7.0) cm、0.92±0.04、(5.37±1.43) mmol/L、(2.29±1.83) mmol/L화(5.10±1.26) mmol/L；대조조분별위(20.73±2.65) kg/m2、(81.6±7.4) cm、0.86±0.05、(5.01±2.66) mmol/L、(1.25±0.94) mmol/L화(4.24±1.63) mmol/L；t치분별시-6.442、5.895、7.452、-3.634、-4.114화2.624,P치균＜0.01,차이균유통계학의의.BMI、WC、WHR、TG、TC균위남성NAFLD적위험인소(P＜0.01),BMI재예측남성NAFLD발생상최유개치(OR=10.819),WHR차지(OR=10.588). 결론 BMI、WC、WHR、TG、TC시남성NAFLD적위험인소,BMI、WHR예측남성NAFLD적개치최고.
Objective To explore risk factors of nonalcoholic fatty liver disease (NAFLD) in men in order to provide a theoretical basis for developing more effective NAFLD prevention and control strategies.Methods One-hundred-and-two male patients (37.3 ± 11.4 years old) hospitalized with NAFLD at the Dongnan Affiliated Hospital of Xiamen University between January 2009 and December 2010 were enrolled in the study,along with 23 age-matched healthy men (34.4 ± 16.7 years old) to serve as the control group.The correlation(s) of body mass index (BMI; overweight defined as ≥ 22.717 kg/m2),waist circumference (WC),waist-to-hip ratio (WHR; central obesity defined as ≥ 0.866),fasting plasma glucose (FPG),triglyceride (TG),and total cholesterol (TC) with NAFLD was analyzed by univariate and multivariate logistic regression analyses.Receiver operating characteristic (ROC) curves were used to select proper thresholds for classification.Results BMI,WC,WHR,FPG,TG,and TC were significantly different between the cases and controls (P ＜ 0.01).BMI,WC,WHR,TG and TC were identified as risk factors of NAFLD in these male cases (P＜ 0.01).Relative to WC,TG and TC,both BMI and WHR had significant predictive value for NAFLD (odds ratio (OR)=10.819 and 10.588,respectively).In addition,BMI had the highest diagnostic value for the prediction of NAFLD (area under the curve (AUC) =0.931) followed by WHR (AUC =0.879).Conclusion BMI,WC,WHR,TG,and TC are risk factors of NAFLD in Chinese men.BMI and WHR are effective anthroposomatology indices of NAFLD and may be useful factors on which to base future prevention and early diagnosis strategies for NAFLD in males.
