中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2013年
3期
202-206
,共5页
于露露%尹梁宇%陈汶%范金虎%崔剑峰%阴建%乔友林%代兴碧
于露露%尹樑宇%陳汶%範金虎%崔劍峰%陰建%喬友林%代興碧
우로로%윤량우%진문%범금호%최검봉%음건%교우림%대흥벽
肝硬化%维生素D%巢式病例对照研究
肝硬化%維生素D%巢式病例對照研究
간경화%유생소D%소식병례대조연구
Liver cirrhosis%Vitamin D%Nested control study
目的 探讨人体血清25-羟维生素D[25-hydroxy vitamin D,25 (OH)D]与肝硬化发病风险的关系.方法 采用巢式病例对照研究设计,用酶联免疫吸附法检测来自营养干预试验队列中282例肝硬化患者和564例随机对照人群基线血清的25 (OH)D及3项肝炎病毒血清学标志物(HBsAg、抗-HBc、抗-HCV)水平,并从调查问卷中收集研究对象相关基线特征信息.以846例研究对象25 (OH)D浓度四分位数为依据将其分为4个区间,用logistic回归模型评价各区间血清25 (OH)D浓度与肝硬化发病风险的关联程度.结果 病例组和对照组25 (OH)D浓度分别为(15.3,13.8) nmol/L与(20.2,16.6) nmol/L,两组比较,差异有统计学意义(t=5.169,P=0.002);以第1区间(最低浓度组)为参考水平,第2、3、4区间OR值及95%置信区间(95%CI)分别为0.495 (0.333 ~ 0.736)、0.452 (0.303 ~ 0.675)、0.349 (0.231 ~ 0.527),对可能的影响因素进行调整后,第2、3、4区间OR值及95% CI分别为0.499 (0.328 ~ 0.759)、0.427(0.278 ~ 0.654)、0.344 (0.222 ~ 0.532),25 (OH)D浓度的升高与肝硬化发病风险的下降存在线性关系(x2=25.200,P<0.01).结论 肝硬化发病风险随血清25 (OH)D浓度的增高而降低,维生素D可能是肝硬化发病的一项保护因素.
目的 探討人體血清25-羥維生素D[25-hydroxy vitamin D,25 (OH)D]與肝硬化髮病風險的關繫.方法 採用巢式病例對照研究設計,用酶聯免疫吸附法檢測來自營養榦預試驗隊列中282例肝硬化患者和564例隨機對照人群基線血清的25 (OH)D及3項肝炎病毒血清學標誌物(HBsAg、抗-HBc、抗-HCV)水平,併從調查問捲中收集研究對象相關基線特徵信息.以846例研究對象25 (OH)D濃度四分位數為依據將其分為4箇區間,用logistic迴歸模型評價各區間血清25 (OH)D濃度與肝硬化髮病風險的關聯程度.結果 病例組和對照組25 (OH)D濃度分彆為(15.3,13.8) nmol/L與(20.2,16.6) nmol/L,兩組比較,差異有統計學意義(t=5.169,P=0.002);以第1區間(最低濃度組)為參攷水平,第2、3、4區間OR值及95%置信區間(95%CI)分彆為0.495 (0.333 ~ 0.736)、0.452 (0.303 ~ 0.675)、0.349 (0.231 ~ 0.527),對可能的影響因素進行調整後,第2、3、4區間OR值及95% CI分彆為0.499 (0.328 ~ 0.759)、0.427(0.278 ~ 0.654)、0.344 (0.222 ~ 0.532),25 (OH)D濃度的升高與肝硬化髮病風險的下降存在線性關繫(x2=25.200,P<0.01).結論 肝硬化髮病風險隨血清25 (OH)D濃度的增高而降低,維生素D可能是肝硬化髮病的一項保護因素.
목적 탐토인체혈청25-간유생소D[25-hydroxy vitamin D,25 (OH)D]여간경화발병풍험적관계.방법 채용소식병례대조연구설계,용매련면역흡부법검측래자영양간예시험대렬중282례간경화환자화564례수궤대조인군기선혈청적25 (OH)D급3항간염병독혈청학표지물(HBsAg、항-HBc、항-HCV)수평,병종조사문권중수집연구대상상관기선특정신식.이846례연구대상25 (OH)D농도사분위수위의거장기분위4개구간,용logistic회귀모형평개각구간혈청25 (OH)D농도여간경화발병풍험적관련정도.결과 병례조화대조조25 (OH)D농도분별위(15.3,13.8) nmol/L여(20.2,16.6) nmol/L,량조비교,차이유통계학의의(t=5.169,P=0.002);이제1구간(최저농도조)위삼고수평,제2、3、4구간OR치급95%치신구간(95%CI)분별위0.495 (0.333 ~ 0.736)、0.452 (0.303 ~ 0.675)、0.349 (0.231 ~ 0.527),대가능적영향인소진행조정후,제2、3、4구간OR치급95% CI분별위0.499 (0.328 ~ 0.759)、0.427(0.278 ~ 0.654)、0.344 (0.222 ~ 0.532),25 (OH)D농도적승고여간경화발병풍험적하강존재선성관계(x2=25.200,P<0.01).결론 간경화발병풍험수혈청25 (OH)D농도적증고이강저,유생소D가능시간경화발병적일항보호인소.
Objective To explore the relation between serum vitamin D (25(OH)D) concentrations and liver cirrhosis.Methods A nested case control study was designed based on the Nutrition Intervention Trial (NIT) cohort,from which non-degraded serum samples and complete baseline and follow-up data were available for 282 individuals diagnosed with liver cirrhosis and 564 healthy controls.The serum samples were tested by enzyme-linked immunosorbent assay to detect and quantify 25(OH)D,as well as hepatitis B virus surface antigen and core antibody and hepatitis C virus antibody.The study participants were divided into four groups according to quartile range of 25(OH)D concentration and logistic regression modeling was used to evaluate the relation with liver cirrhosis risk by estimating odds ratios (ORs) and 95% confidence intervals (CIs).Results The liver cirrhosis group had a significantly lower concentration of 25(OH)D than the control group (median and quartile range in nmol/L,cases:15.3 and 13.8;controls:20.2 and 16.6;t =5.169,P =0.002).When the first interval was set as the reference level,the ORs(95% CIs) of the second,third,and fourth intervals were:0.495(0.333 ~ 0.736),0.452(0.303 ~ 0.675),and 0.349(0.231 ~ 0.527).After adjusting the analysis for the presence of pathogenic-related confounding factors,the ORs(95% CIs) of the second,third,and fourth intervals were:0.499(0.328 ~ 0.759),0.427(0.278 ~ 0.654),and 0.344(0.222~ 0.532).The 25(OH)D level was inversely correlated with risk of liver cirrhosis (x2 =25.200,P < 0.001).Conclusion Risk of liver cirrhosis increases as 25(OH)D serum concentration decreases.Vitamin D might function as a protective factor against development of cirrhosis.