中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2014年
5期
340-343
,共4页
姜曼%辛永宁%王卫滨%林中华%张丁丁%李长严%姜相君%宣世英
薑曼%辛永寧%王衛濱%林中華%張丁丁%李長嚴%薑相君%宣世英
강만%신영저%왕위빈%림중화%장정정%리장엄%강상군%선세영
肝炎,乙型,慢性%肝炎病毒,乙型%多态性,单核苷酸%PNPLA3
肝炎,乙型,慢性%肝炎病毒,乙型%多態性,單覈苷痠%PNPLA3
간염,을형,만성%간염병독,을형%다태성,단핵감산%PNPLA3
Hepatitis B,chronic%Hepatitis B virus%Polymorphism,single nucleotide%PNPLA3
目的 探讨PNPLA3基因rs738409 (C→G)多态性与青岛地区汉族人群慢性乙型肝炎的相关性.方法 收集185例慢性乙型肝炎(CHB)患者和164名正常人的血液标本,采用多聚酶链反应及DNA测序法分析PNPLA3基因型.计数资料比较进行x2检验,计量资料进行t检验,非条件logistic回归模型计算比值比(OR)及其95％可信区间(CI).结果 CHB组rs738409 G等位基因占31.9％,正常对照组为21.9％,两组等位基因频率差异有统计学意义(P＜0.05);G等位基因携带者患CHB的风险是C等位基因的1.67倍(OR=1.67,95％CI为1.18 ～ 2.34,P=0.003).经混杂因素校正后,logistic回归模型分析结果显示,与CC纯合子携带者相比,携带危险等位基因G的GG+ AG基因型增加CHB的发生风险,OR=1.76,95％ CI为1.14 ～ 2.71.结论 在青岛地区汉族人群中,PNPLA3基因rs738409 G等位基因者患CHB的风险性增加.
目的 探討PNPLA3基因rs738409 (C→G)多態性與青島地區漢族人群慢性乙型肝炎的相關性.方法 收集185例慢性乙型肝炎(CHB)患者和164名正常人的血液標本,採用多聚酶鏈反應及DNA測序法分析PNPLA3基因型.計數資料比較進行x2檢驗,計量資料進行t檢驗,非條件logistic迴歸模型計算比值比(OR)及其95％可信區間(CI).結果 CHB組rs738409 G等位基因佔31.9％,正常對照組為21.9％,兩組等位基因頻率差異有統計學意義(P＜0.05);G等位基因攜帶者患CHB的風險是C等位基因的1.67倍(OR=1.67,95％CI為1.18 ～ 2.34,P=0.003).經混雜因素校正後,logistic迴歸模型分析結果顯示,與CC純閤子攜帶者相比,攜帶危險等位基因G的GG+ AG基因型增加CHB的髮生風險,OR=1.76,95％ CI為1.14 ～ 2.71.結論 在青島地區漢族人群中,PNPLA3基因rs738409 G等位基因者患CHB的風險性增加.
목적 탐토PNPLA3기인rs738409 (C→G)다태성여청도지구한족인군만성을형간염적상관성.방법 수집185례만성을형간염(CHB)환자화164명정상인적혈액표본,채용다취매련반응급DNA측서법분석PNPLA3기인형.계수자료비교진행x2검험,계량자료진행t검험,비조건logistic회귀모형계산비치비(OR)급기95％가신구간(CI).결과 CHB조rs738409 G등위기인점31.9％,정상대조조위21.9％,량조등위기인빈솔차이유통계학의의(P＜0.05);G등위기인휴대자환CHB적풍험시C등위기인적1.67배(OR=1.67,95％CI위1.18 ～ 2.34,P=0.003).경혼잡인소교정후,logistic회귀모형분석결과현시,여CC순합자휴대자상비,휴대위험등위기인G적GG+ AG기인형증가CHB적발생풍험,OR=1.76,95％ CI위1.14 ～ 2.71.결론 재청도지구한족인군중,PNPLA3기인rs738409 G등위기인자환CHB적풍험성증가.
Objective To investigate the association between the PNPLA3 rs738409 polymorphism and chronic hepatitis B (CH[B) in a Han Chinese population residing in Qingdao.Methods Peripheral blood samples were collected from 185 CHB patients and 164 healthy controls and subjected to polymerase chain reaction (PCR) and DNA sequencing to determine the PNPLA3 genotypes.The relative risk of the rs738409 polymorphism for CHB was estimated by calculating the odds ratio (OR) and 95％ confidence interval.Results The rs738409 G allele frequency was significantly different between the CHB and control groups (31.9％ vs.21.9％ respectively,P ＜ 0.05).Compared to he rs738409 C allele,the G allele was associated with an increased risk of developing CHB (OR =1.67,95％ CI:1.18-2.34,P =0.003).Logistic regression model analysis,with adjustment for confounding factors,indicated that carriers of the PNPLA3 rs738409 GG + GC genotype had increased risk of CHB than carriers of the CC genotype (OR =1.76,95％ CI:1.14-2.71,P =0.011).Conclusion Qingdao Han Chinese who are carriers of the rs738409 G allele are at increased risk of CHB.
