CAJ | 학술논문

目的通过研究新密地区女性人群戊型肝炎病毒抗体(HEV-.gG)、人乳头瘤病毒抗体(HPV.gG)的分布情况与人群行为习惯,了解该地区目标人群的HEV-IgG分布状况及其危险因素.方法通过问卷调查,获得目标人群的一般状况、行为史;再通过实验室检测,获得HEV与HPV的抗体情况.对问卷结果进行统计描述,并用t检验、x2检验和二元logistic回归分析的方法了解影响HE V-.gG阳性率的危险因素.结果新密地区目标女性年龄(47.16±8.09)岁,85.8％为农民,44.5％属于低收入人群;样本人群HPV IgG阳性率26.80％,HEV-IgG阳性率30.99％,阳性率由35岁以下组的15.80％上升至61岁以上组的47.62％,上升具有统计学意义(P＜0.05).单因素分析中,是否接受教育、是否为低收入人群、有无死产经历和年龄因素为HEV-IgG阳性的危险因素;多因素分析显示,年龄、是否为低收入人群、是否为农民是HEV-IgG阳性的相关因素.结论河南新密地区女性HEV-IgG阳性率较以往文献报道的结果高,且随年龄增长而阳性率上升;高龄、低收入与从事农业活动是HEV-IgG的危险因素,有无死产这一因素与HEV-IgG的关系需要进一步研究证实;HEV抗体与HPV抗体尚未见统计学关联,也未见性行为与HEV感染之间的关联.
목적 통과연구신밀지구녀성인군무형간염병독항체(HEV-.gG)、인유두류병독항체(HPV.gG)적분포정황여인군행위습관,료해해지구목표인군적HEV-IgG분포상황급기위험인소.방법 통과문권조사,획득목표인군적일반상황、행위사;재통과실험실검측,획득HEV여HPV적항체정황.대문권결과진행통계묘술,병용t검험、x2검험화이원logistic회귀분석적방법료해영향HE V-.gG양성솔적위험인소.결과 신밀지구목표녀성년령(47.16±8.09)세,85.8％위농민,44.5％속우저수입인군;양본인군HPV IgG양성솔26.80％,HEV-IgG양성솔30.99％,양성솔유35세이하조적15.80％상승지61세이상조적47.62％,상승구유통계학의의(P＜0.05).단인소분석중,시부접수교육、시부위저수입인군、유무사산경력화년령인소위HEV-IgG양성적위험인소;다인소분석현시,년령、시부위저수입인군、시부위농민시HEV-IgG양성적상관인소.결론 하남신밀지구녀성HEV-IgG양성솔교이왕문헌보도적결과고,차수년령증장이양성솔상승;고령、저수입여종사농업활동시HEV-IgG적위험인소,유무사산저일인소여HEV-IgG적관계수요진일보연구증실;HEV항체여HPV항체상미견통계학관련,야미견성행위여HEV감염지간적관련.
Objective To determine the distribution of anti-hepatitis E virus (HEV) IgG antibody and anti-human papilloma virus (HPV) IgG antibody among female residents of Xinmi and investigate the risk factors of HEV infection.Methods A questionnaire was used to collect data on the demographic characteristics and suspected risk factors of HEV infection,including behavioral habits.All questionnaire reponders also provided peripheral blood samples for investigation by enzyme-linked immunosorbent assay to detect HEV-IgG.Demographic data were statistically evaluated by t-test and univariate analysis,and HEV infection risk factors were statistically evaluated by a binary logistic regression model.Results The average age of the 952 questionnaire responders was 47.16 + 8.09 years.The demographic parameters of education level,income,experience of stillbirth,and age were associated with HEV-IgG positivity (allP ＜ 0.05).Age,occupation,and income were identified as independent risk factors for HEV-IgG positivity (all P ＜ 0.05).No statical association was found between sexual behavior and anti-HEV or anti-HPV levels,or HEV infection.Conclusion The female population surveyed in Xinmi,Henan Province showed a higher HEV-IgG positive rate than generally reported in the literature,and this rate shows an increasing trend with age,Risk factors for HEV infection among this group are age,income and occupation.