CAJ | 학술논문

目的对比分析瞬时弹性成像和实时组织弹性成像评估慢性肝病肝纤维化的价值.方法对92例行肝组织学检查的慢性肝病患者同时行瞬时弹性成像和实时组织弹性成像检查,以肝组织病理学检查结果为金标准,比较瞬时弹性成像和实时组织弹性成像与肝纤维化病理分期的相关系数、诊断肝纤维化的受试者工作特征曲线下面积. 结果瞬时弹性成像与肝纤维化病理分期的相关系数(r=0.755,95％ CI0.651 ～ 0.831,P=0.000)高于实时组织弹性成像(r=0.481,95％CI0.306 ～ 0.624,P=0.000),Z=3.07,P=0.002.瞬时弹性成像和实时组织弹性成像诊断肝纤维化(S≥2)、肝硬化(S=4)的受试者工作特征曲线下面积分别为0.903和0.740、0.915和0.786,瞬时弹性成像高于实时组织弹性成像(P值分别为0.003和0.020). 结论瞬时弹性成像诊断慢性肝病肝纤维化效能优于实时组织弹性成像,但后者与二维超声图像融合,具有广泛的应用前景.
목적 대비분석순시탄성성상화실시조직탄성성상평고만성간병간섬유화적개치.방법 대92례행간조직학검사적만성간병환자동시행순시탄성성상화실시조직탄성성상검사,이간조직병이학검사결과위금표준,비교순시탄성성상화실시조직탄성성상여간섬유화병리분기적상관계수、진단간섬유화적수시자공작특정곡선하면적. 결과 순시탄성성상여간섬유화병리분기적상관계수(r=0.755,95％ CI0.651 ～ 0.831,P=0.000)고우실시조직탄성성상(r=0.481,95％CI0.306 ～ 0.624,P=0.000),Z=3.07,P=0.002.순시탄성성상화실시조직탄성성상진단간섬유화(S≥2)、간경화(S=4)적수시자공작특정곡선하면적분별위0.903화0.740、0.915화0.786,순시탄성성상고우실시조직탄성성상(P치분별위0.003화0.020). 결론 순시탄성성상진단만성간병간섬유화효능우우실시조직탄성성상,단후자여이유초성도상융합,구유엄범적응용전경.
Objective To compare the abilities of transient elastography (TE) versus real-time tissue elastography (RTE) for assessing liver fibrosis in patients with chronic liver disease.Methods Ninetytwo patients with chronic liver disease were enrolled in the study,and included 77 cases of chronic hepatitis B,4 cases of chronic hepatitis C,4 cases of autoimmune liver disease,2 cases of primary biliary cirrhosis,Ⅰ case of abnormal bile duct development,and 4 cases of unknown etiology.All patients were assessed by both TE and RTE in a single day.The correlation coefficient of liver fibrosis level and the receiver operating characteristic (ROC) curve of S ＞ 2 and =4 of TE and RTE were determined.The values were compared using findings fiom pathological analysis as reference.Results The correlation coefficient of liver fibrosis level was significantly higher for TE (r =0.755,95％ CI:0.651-0.831,P =0.000) than for RTE (r=0.481,95％ CI:0.306-0.624,P =0.000) (Z=3.07,P =0.002).The areas under the ROC curves for S ＞ 2 and =4 were 0.903 and 0.740 for TE and 0.915 and 0.786 for RTE,respectively,indicating that the performance of TE was superior to that of RTE.Conclusion TE was superior to RTE for assessment of liver fibrosis.