中华航海医学与高气压医学杂志
中華航海醫學與高氣壓醫學雜誌
중화항해의학여고기압의학잡지
CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
2013年
1期
19-21
,共3页
周旋%韩昕健%陈鹏%韩东
週鏇%韓昕健%陳鵬%韓東
주선%한흔건%진붕%한동
胰腺炎%高压氧%内皮素%一氧化氮
胰腺炎%高壓氧%內皮素%一氧化氮
이선염%고압양%내피소%일양화담
Hyperbaric oxygen%Acute pancreatitis%Endothelin%Nitric oxide
目的 观察高压氧(hyperbaric oxygen,HBO)对急性胰腺炎(acute pancreatitis,AP)患者血浆内皮素(endothelin,ET)及一氧化氮(nitric oxide,NO)水平的影响,探讨HBO对AP患者微循环改善情况.方法 经患者知情同意后,将84例AP患者分为HBO治疗组(HBO组,42例)和常规治疗组(常规组,42例).常规组给予常规药物治疗,HBO组在常规治疗的基础上加用HBO治疗.分别于治疗前后检测所有患者的ET、NO、血及尿淀粉酶水平,同时进行Balthazar CT分级评分、APACHEⅡ评分及腹痛缓解情况评定.选择同期健康体检者30名作为对照.结果 治疗后2组患者ET、NO、血及尿淀粉酶水平均明显下降[常规组ET、NO、血及尿淀粉酶水平分别为(83.76 ±21.56) ng/L、(93.67±20.18) mmol/L、(1982.9±927.4) U/L、(1178.3±546.7) U/L; HBO组分别为(42.75±13.68) ng/L、(65.83 ±21.64)mmol/L、(1517.3 ±370.2) U/L、(810.7±189.6) U/L],差异均有统计学意义(P＜0.05),HBO组下降更明显.Balthazar CT分级评分、APACHEⅡ评分及腹痛缓解时间较治疗前明显降低[常规组分别为7.09±0.87、10.47±1.08、(5.13±0.68)d,HBO组分别为5.32 ±0.67、6.49 ±0.78、(2.18±0.84)d],差异均有统计学意义(P ＜0.05)；HBO组下降更明显.结论 血浆ET、NO异常变化可能是AP发生、发展的主要因素之一,HBO能较好地改善AP患者胰腺微循环障碍,对AP有一定的治疗作用.
目的 觀察高壓氧(hyperbaric oxygen,HBO)對急性胰腺炎(acute pancreatitis,AP)患者血漿內皮素(endothelin,ET)及一氧化氮(nitric oxide,NO)水平的影響,探討HBO對AP患者微循環改善情況.方法 經患者知情同意後,將84例AP患者分為HBO治療組(HBO組,42例)和常規治療組(常規組,42例).常規組給予常規藥物治療,HBO組在常規治療的基礎上加用HBO治療.分彆于治療前後檢測所有患者的ET、NO、血及尿澱粉酶水平,同時進行Balthazar CT分級評分、APACHEⅡ評分及腹痛緩解情況評定.選擇同期健康體檢者30名作為對照.結果 治療後2組患者ET、NO、血及尿澱粉酶水平均明顯下降[常規組ET、NO、血及尿澱粉酶水平分彆為(83.76 ±21.56) ng/L、(93.67±20.18) mmol/L、(1982.9±927.4) U/L、(1178.3±546.7) U/L; HBO組分彆為(42.75±13.68) ng/L、(65.83 ±21.64)mmol/L、(1517.3 ±370.2) U/L、(810.7±189.6) U/L],差異均有統計學意義(P＜0.05),HBO組下降更明顯.Balthazar CT分級評分、APACHEⅡ評分及腹痛緩解時間較治療前明顯降低[常規組分彆為7.09±0.87、10.47±1.08、(5.13±0.68)d,HBO組分彆為5.32 ±0.67、6.49 ±0.78、(2.18±0.84)d],差異均有統計學意義(P ＜0.05)；HBO組下降更明顯.結論 血漿ET、NO異常變化可能是AP髮生、髮展的主要因素之一,HBO能較好地改善AP患者胰腺微循環障礙,對AP有一定的治療作用.
목적 관찰고압양(hyperbaric oxygen,HBO)대급성이선염(acute pancreatitis,AP)환자혈장내피소(endothelin,ET)급일양화담(nitric oxide,NO)수평적영향,탐토HBO대AP환자미순배개선정황.방법 경환자지정동의후,장84례AP환자분위HBO치료조(HBO조,42례)화상규치료조(상규조,42례).상규조급여상규약물치료,HBO조재상규치료적기출상가용HBO치료.분별우치료전후검측소유환자적ET、NO、혈급뇨정분매수평,동시진행Balthazar CT분급평분、APACHEⅡ평분급복통완해정황평정.선택동기건강체검자30명작위대조.결과 치료후2조환자ET、NO、혈급뇨정분매수평균명현하강[상규조ET、NO、혈급뇨정분매수평분별위(83.76 ±21.56) ng/L、(93.67±20.18) mmol/L、(1982.9±927.4) U/L、(1178.3±546.7) U/L; HBO조분별위(42.75±13.68) ng/L、(65.83 ±21.64)mmol/L、(1517.3 ±370.2) U/L、(810.7±189.6) U/L],차이균유통계학의의(P＜0.05),HBO조하강경명현.Balthazar CT분급평분、APACHEⅡ평분급복통완해시간교치료전명현강저[상규조분별위7.09±0.87、10.47±1.08、(5.13±0.68)d,HBO조분별위5.32 ±0.67、6.49 ±0.78、(2.18±0.84)d],차이균유통계학의의(P ＜0.05)；HBO조하강경명현.결론 혈장ET、NO이상변화가능시AP발생、발전적주요인소지일,HBO능교호지개선AP환자이선미순배장애,대AP유일정적치료작용.
Objective To study the effects of HBO on plasma endotbelin (ET) and nitric oxide (NO) in patients with acute pancreatitis (AP),and also to explore improvement of microcirculation in the patients with AP.Methods Eighty-four patients with AP were randomly divided into 2 groups:the HBO group (n =42) and the routine treatment group (n =42),with informed consent and following signing a letter of agreement.The routine treatment group was just given routine drug treatment,while the HBO group received HBO treatment in addition to routine drug treatment.Levels of ET,NO,AMLY and UAMY were measured both before and after treatment.At the same time,scores of Balthazar CT,APACHEⅡ and relief of abdominal pain were evaluated and compared between the 2 groups.In addition,30 healthy subjects were recruited at the same time as the control group.Results The levels of ET,NO,AMLY and UAMY of the patients in both groups decreased significantly following treatment,with statistical significance,but with the levels of the said data of the patients in the HBO group decreased more significantly.Scores of Balthazar CT and APACHE Ⅱ and relief time of abdominal pain were decreased significantly,when compared with those before treatment,with the scores of the HBO group decreased more significantly.Conclusions Abnormal changes in the levels of plasma ET and NO might be one of the important factors for the occurrence and development of AP.HBO could obviously improve microcirculation of the patients with AP,and might have certain therapeutic effect on AP.
