CAJ | 학술논문

目的探索高压氧(HBO)联合药物治疗梅尼埃病的中长期临床疗效.方法将120名梅尼埃病(MD)患者按照治疗方法分为观察组(60例)和对照组(60例).对照组给予常规药物治疗,观察组在对照组治疗的基础上给予HBO治疗.对HBO治疗前、治疗后1个月及6个月的治疗效果进行比较,并进行耳部检查和鼓室功能曲线测试,探讨HBO治疗的中长期疗效及并发症.结果 HBO组治疗后1个月及6个月DHI评分[分别为(39.22±14.47)分、(32.75±11.52)分]均显著低于治疗前[(58.18±20.35)分],差异均有统计学意义(P＜0.05)；HBO组听力和语言识别率提高,MD发作频率降低,与对照组相比差异有统计学意义(P＜0.05)；HBO组MD治疗显效率(68.33％)和有效率(93.33％)均高于对照组,差异均有统计学意义(P＜0.05)；2组不良反应均较少,差异无统计学意义(P＞0.05).结论应用HBO综合治疗MD疗效确切,治疗6个月临床疗效高于治疗1个月,且病情无反复.
목적 탐색고압양(HBO)연합약물치료매니애병적중장기림상료효.방법 장120명매니애병(MD)환자안조치료방법분위관찰조(60례)화대조조(60례).대조조급여상규약물치료,관찰조재대조조치료적기출상급여HBO치료.대HBO치료전、치료후1개월급6개월적치료효과진행비교,병진행이부검사화고실공능곡선측시,탐토HBO치료적중장기료효급병발증.결과 HBO조치료후1개월급6개월DHI평분[분별위(39.22±14.47)분、(32.75±11.52)분]균현저저우치료전[(58.18±20.35)분],차이균유통계학의의(P＜0.05)；HBO조은력화어언식별솔제고,MD발작빈솔강저,여대조조상비차이유통계학의의(P＜0.05)；HBO조MD치료현효솔(68.33％)화유효솔(93.33％)균고우대조조,차이균유통계학의의(P＜0.05)；2조불량반응균교소,차이무통계학의의(P＞0.05).결론 응용HBO종합치료MD료효학절,치료6개월림상료효고우치료1개월,차병정무반복.
Objective To investigate medium-long-term clinical effects of hyperbaric oxygen (HBO) combined with drugs on Ménière's disease MD.Methods In accordance with different treatment methods,120 patients with Ménière's disease were divided into the experimental group (n =60) and the control group (n =60).Patients in the control group received routine drug treatment,while patients in the experimental group received HBO in addition to routine drug treatment,all with one treatment course of 10 sessions.Therapeutic effects were compared between pre-HBO therapy,one month after HBO therapy and 6 months after therapy.Aural test and tympanometry curve test were also performed to see the mid-tern effect of HBO,as well as complications that might occur.Results DHI scores 1 month and 6 months after therapy for the patients of theexperimental group were (39.22 ± 14.47) and (32.75 ± 11.52),which were significantly lower than those before therapy,with statistical significance (P ＜ 0.05).Hearing and speech discrimination scores for the patients of the experimental group improved,and MD seizure frequency significantly decreased.Statistical significance could be seen,when comparisons were made between the 2 groups (P ＜ 0.05).MD control rate (68.33％) and effective rate (93.33 ％) for the experimental group were all higher than those of the control group,with statistical significance (P ＜ 0.05).Few adverse reactions could be seen in the 2 groups,and no statistical significance could be noted in them (P ＞ 0.05).Conclusions HBO combined with routine drugs could produce reliable effect on Meniere 's disease,and 6-month comprehensive HBO therapy could produce better effect than that of 1 month comprehensive HBO therapy.What's more,no recurrence was seen and its therapeutic effect was definite.