CAJ | 학술논문

目的探讨口服脑复康对模拟65 m氦氧饱和潜水人员生理功能的影响.方法采用随机对照双盲试验,7名健康男性潜水员分为2组,实验组(3人)在进舱前3d开始口服中等剂量脑复康(2.4 g/d),直到出舱后1周;对照组(4人)给予同等形状的赋形剂,剂量及口服时间相同.观察2组在模拟65 m氦氧饱和潜水暴露过程中呼吸、脉搏、血压、尿量、血清肝肾功能等指标的变化.结果2组人员每日呼吸、脉搏、尿量没有明显变化;与加压前相比,对照组在加压和逗留期舒张压增高(P＜0.05),而实验组在上述时间点低于对照组(P＜0.05);实验组在减压末期收缩压明显低于对照组(P＜0.01),也低于加压前(P＜0.05);实验组血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)浓度在出舱后高于进舱前,而对照组在出舱后低于进舱前,但差异无统计学意义.结论口服脑复康不会给模拟65 m氦氧饱和潜水人员带来显著不利影响.
목적 탐토구복뇌복강대모의65 m양양포화잠수인원생리공능적영향.방법 채용수궤대조쌍맹시험,7명건강남성잠수원분위2조,실험조(3인)재진창전3d개시구복중등제량뇌복강(2.4 g/d),직도출창후1주;대조조(4인)급여동등형상적부형제,제량급구복시간상동.관찰2조재모의65 m양양포화잠수폭로과정중호흡、맥박、혈압、뇨량、혈청간신공능등지표적변화.결과2조인원매일호흡、맥박、뇨량몰유명현변화;여가압전상비,대조조재가압화두류기서장압증고(P＜0.05),이실험조재상술시간점저우대조조(P＜0.05);실험조재감압말기수축압명현저우대조조(P＜0.01),야저우가압전(P＜0.05);실험조혈청병안산안기전이매(ALT)、천동안산안기전이매(AST)농도재출창후고우진창전,이대조조재출창후저우진창전,단차이무통계학의의.결론구복뇌복강불회급모의65 m양양포화잠수인원대래현저불리영향.
Objective To investigate the effects of piracetam per os on the physiological functions of divers during the simulated 65 m heliox saturation dive.Methods A double-blind experiment was conducted by 7 healthy male divers,who were randomly divided into two groups:the experimental group (n =3) and the control group (n =4).The subjects in the experimental group began to take piracetam (2.4 g/d) 3 days before entrance into the chamber until one week after they came out of the chamber.The 4 subjects in the control group received excipient at the same time and at the same dose.Changes in respiratory frequency,pulse,blood pressure,24-h urine output and hepatic and renal functions of the divers were observed closely.Results No obvious changes could be noted in respiratory frequency,pulse and 24-h urine output in the two groups.As compared with that before pressure exposure,the diastolic pressure of the divers in the control group increased (P ＜ 0.05),while the diastolic pressure of the divers in the experimental group was lower than that of the control group at the same time points (P ＜ 0.05).The systolic pressure of the divers in the experimental group at the end of decompression was obviously lower than that of the control group (P ＜ 0.05).The concentrations of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the divers of the experimental group after exposure were higher than those before exposure,while the levels of ALT and AST in the control group following exposure were lower than those before exposure,but without statistical significance (P ＜ 0.05).Conclusions Piracetam per os at high pressure seemed to have little adverse effect on divers during the 65m heliox saturation dive.