CAJ | 학술논문

目的观察脑梗死患者血清同型半胱氨酸(Hcy)、高敏C反应蛋白(hsCRP)和血浆D-二聚体(DD)的含量及高压氧(HBO)对这些指标的影响.方法经患者知情同意及医院伦理委员会批准后,将120例脑梗死患者按照自愿原则分为治疗组和对照组,每组60例.对照组和治疗组患者分别给予药物治疗和药物加HBO治疗.测定治疗前后患者Hcy、hsCRP和DD含量,并观察2组患者治疗前后神经功能缺损评分(NDF)的变化.结果治疗前2组患者的Hcy、hsCRP和DD的测定值均明显高于正常范围,经过治疗后均明显下降(P＜0.01);与对照组相比,治疗组Hcy、hsCRP和DD含量下降明显(P＜0.05或P＜0.01).治疗后2组患者的NDF较治疗前均明显下降(P＜0.01),而治疗组下降更明显(P＜0.01).结论 HBO治疗可以明显降低脑梗死患者Hcy、hsCRP和DD的含量,有利于脑梗死患者康复.
목적 관찰뇌경사환자혈청동형반광안산(Hcy)、고민C반응단백(hsCRP)화혈장D-이취체(DD)적함량급고압양(HBO)대저사지표적영향.방법 경환자지정동의급의원윤리위원회비준후,장120례뇌경사환자안조자원원칙분위치료조화대조조,매조60례.대조조화치료조환자분별급여약물치료화약물가HBO치료.측정치료전후환자Hcy、hsCRP화DD함량,병관찰2조환자치료전후신경공능결손평분(NDF)적변화.결과 치료전2조환자적Hcy、hsCRP화DD적측정치균명현고우정상범위,경과치료후균명현하강(P＜0.01);여대조조상비,치료조Hcy、hsCRP화DD함량하강명현(P＜0.05혹P＜0.01).치료후2조환자적NDF교치료전균명현하강(P＜0.01),이치료조하강경명현(P＜0.01).결론 HBO치료가이명현강저뇌경사환자Hcy、hsCRP화DD적함량,유리우뇌경사환자강복.
Objective To observe the contents of homocysteine (Hcy),C-reactive protein (hsCRP) and D-dimer(DD) in patients with cerebral infarction and the effects of hyperbaric oxygen (HBO) on them.Methods One hundred and twenty cases of cerebral infarction were voluntarily divided into 2 groups,the control group and the therapy group,each consisting of 60 cases.The patients of the control group received drug treatment,while the therapy group received HBO treatment in addition to routine drug treatment.The levels of Hcy,hsCRP and DD in the patients of the 2 groups were measured both before and after therapy,and changes in neurological functional defect (NFD) were also evaluated both before and after treatment.Results For both groups,the levels of Hcy,hsCRP and DD before therapy were higher than the normal reference value,and they all significantly decreased following therapy (P ＜ 0.01).When compared with those of the control group,the levels of Hcy,hsCRP and DD all decreased significantly (P ＜ 0.05 or P ＜ 0.01).The NFD in the patients of both group were decreased after therapy(P ＜ 0.01),with the NFD decreased more significantly in the patients of the therapy group (P ＜ 0.01).Conclusions HBO therapy could obviously reduced the levels of Hcy,hsCRP and DD in patients with cerebral infarction,which might be beneficial to the recovery of patients with cerebral infarction.