CAJ | 학술논문

目的探讨远航对潜艇官兵神经内分泌和免疫系统的影响.方法选取潜艇官兵55名做为研究对象,采用酶联免疫吸附法(ELISA)检测55名官兵的血清肌酸激酶(CK)、三酰甘油(TG)、葡萄糖(GLU)和尿酸(UA)水平,并利用试剂盒检测其中36名官兵血清去甲肾上腺素(NE)、皮质醇(COR)、热休克蛋白70(HSP70)、白细胞介素也(IL-2)和白细胞介素4(IL-4)水平.结果 (1)远航后NE[(313.68±146.51) ng/L]较远航前[(224.80±118.52) ng/L]升高,差异有统计学意义(P＜0.01);远航后COR[(18.40 ±6.91)μg/L]较远航前[(14.73 ±8.70) μg/L]略有升高(P=0.075);HSP70远航后[(149.02 ±72.22) μg/L]较远航前[(109.02 ±59.92) μg/L]升高,差异有统计学意义(P＜0.05).(2)远航后GLU[(4.27 ±0.67) mmol/L]较远航前[(4.60 ±0.56) mmol/L]降低,差异有统计学意义(P＜0.05);CK、TG和UA远航后[(217.76±181.21)U/L、(2.05 ±0.91) mmol/L、(407.11±60.81) μmol/L]均较远航前[(119.67 ±75.88) U/L、(1.32±0.55) mmol/L、330.18 ±70.93) μmol/L]升高,差异有统计学意义(P＜0.01).(3)远航后IL-2、IL-4[(424.44±166.04) ng/L、(361.13±163.47) ng/L]均较远航前[(331.95±173.11)ng/L、(246.42±166.20) ng/L]升高,差异有统计学意义(P＜0.05).结论远航对潜艇官兵的免疫系统产生了一定的激活作用,并可引起神经内分泌生化指标的改变.
목적 탐토원항대잠정관병신경내분비화면역계통적영향.방법 선취잠정관병55명주위연구대상,채용매련면역흡부법(ELISA)검측55명관병적혈청기산격매(CK)、삼선감유(TG)、포도당(GLU)화뇨산(UA)수평,병이용시제합검측기중36명관병혈청거갑신상선소(NE)、피질순(COR)、열휴극단백70(HSP70)、백세포개소야(IL-2)화백세포개소4(IL-4)수평.결과 (1)원항후NE[(313.68±146.51) ng/L]교원항전[(224.80±118.52) ng/L]승고,차이유통계학의의(P＜0.01);원항후COR[(18.40 ±6.91)μg/L]교원항전[(14.73 ±8.70) μg/L]략유승고(P=0.075);HSP70원항후[(149.02 ±72.22) μg/L]교원항전[(109.02 ±59.92) μg/L]승고,차이유통계학의의(P＜0.05).(2)원항후GLU[(4.27 ±0.67) mmol/L]교원항전[(4.60 ±0.56) mmol/L]강저,차이유통계학의의(P＜0.05);CK、TG화UA원항후[(217.76±181.21)U/L、(2.05 ±0.91) mmol/L、(407.11±60.81) μmol/L]균교원항전[(119.67 ±75.88) U/L、(1.32±0.55) mmol/L、330.18 ±70.93) μmol/L]승고,차이유통계학의의(P＜0.01).(3)원항후IL-2、IL-4[(424.44±166.04) ng/L、(361.13±163.47) ng/L]균교원항전[(331.95±173.11)ng/L、(246.42±166.20) ng/L]승고,차이유통계학의의(P＜0.05).결론 원항대잠정관병적면역계통산생료일정적격활작용,병가인기신경내분비생화지표적개변.
Objective To investigate the effects of prolonged deployment at sea on the neuronendocrine-immune system of submariners.Methods Fifty-five submariners were screened for the study.The levels of creatine kinase (CK),trigeminal ganglion (TG),glucose (GLU) and uric acid (UA) were detected with ELISA,and levels of serum norepinephrine (NE),corticosteroid (COR),heat shock protein (HSP70),interleukin 2 (IL-2) and IL-4 were also detected with testing kits in 36 research subjects.Results (1) The level of NE [(313.68 ±146.51)ng/L] measured after prolonged deployment was significantly higher than that measured before deployment [(224.80 ± 118.52) ng/L] (P ＜ 0.01),the level of COR[(18.40 ± 6.91) μg/L] after prolonged deployment elevated slightly than that before deployment [(14.73 ± 8.70) μg/L] (P =0.075),and the level of HSP70 [(149.02 ± 72.22) μg/L] after the prolonged deployment elevated considerably,as compared with that before deployment [(109.02 ± 59.92) μg/L] (P ＜ 0.05).(2) The level of GLU [(4.27 ± 0.67)mmol/L] measured after prolonged deployment decreased considerably,as compared with that of predeployment [(4.60 ± 0.56)mmol/L] (P ＜ 0.05),the levels of C K,TG and UA [(217.76 ± 181.21)U/L,(2.05 ± 0.91)mmol/L and(407.11 ± 60.81)μmol/L] after the prolonged deployment elevated significantly,as compared with those [(119.67 ± 75.88) U/L,(1.32 ± 0.55) mmol/L and (330.18 ± 70.93) μmol/L] before deployment (P ＜ 0.01).(3) The levels of IL-2 and IL-4 [(424.44 ± 166.04) ng/L,(361.13 ± 163.47)ng/L]measured after deployment were significantly higher than those [(331.95 ±173.11)ng/L and (246.42 ± 166.20) ng/L] before deployment (P ＜ 0.05).Conclusions Prolonged deployment at sea could activate the immune system of submariners to a certain extent and might induce changes in neuroendocrinology.