CAJ | 학술논문

目的观察高压氧(hyperbaric oxygen,HBO)联合糖皮质激素(glucocorticoid,GC)对难治性突发性聋临床疗效.方法经患者知情同意,并经医院伦理委员会批准,根据患者是否使用GC治疗,将有完整临床资料的79例突发性聋患者分为HBO联合GC治疗组44例,单纯HBO组35例.另外,在我院同期耳鼻喉科收治的复诊就医的突发聋患者中,选取使用GC治疗但未进行HBO治疗患者32例,作为单纯GC组.通过分析治疗有效率、治愈率和听力改善率,对比联合治疗与单纯HBO治疗及单纯GC药物治疗的疗效差异.结果 HBO联合GC组患者的治疗有效率(59.52％)和听力改善率[(61.3±14.7)％]明显高于单纯HBO组[28.13％,(43.6±5.5)％]和单纯GC组[31.25％,(56.4±4.1)％].结论对难治性突发性聋HBO联合GC较单纯HBO治疗或GC治疗效果更好.
목적 관찰고압양(hyperbaric oxygen,HBO)연합당피질격소(glucocorticoid,GC)대난치성돌발성롱림상료효.방법 경환자지정동의,병경의원윤리위원회비준,근거환자시부사용GC치료,장유완정림상자료적79례돌발성롱환자분위HBO연합GC치료조44례,단순HBO조35례.령외,재아원동기이비후과수치적복진취의적돌발롱환자중,선취사용GC치료단미진행HBO치료환자32례,작위단순GC조.통과분석치료유효솔、치유솔화은력개선솔,대비연합치료여단순HBO치료급단순GC약물치료적료효차이.결과 HBO연합GC조환자적치료유효솔(59.52％)화은력개선솔[(61.3±14.7)％]명현고우단순HBO조[28.13％,(43.6±5.5)％]화단순GC조[31.25％,(56.4±4.1)％].결론 대난치성돌발성롱HBO연합GC교단순HBO치료혹GC치료효과경호.
Objective Observe the therapeutic effects of hyperbaric oxygen (HB0) combined with glucocorticoid (GC) on refractory idiopathic sudden deafness.Methods Forty-two patients with sudden deafness (refractory idiopathic sudden deafness),who failed to recover after over one month of onset,were admitted into our Center from 2010 to 2013 for treatment with HBO combined with GC (referred to as the combined treatment group).Another 2 groups of patients with refractory idiopathic sudden deafness (each consisting of 32 patients),who were admitted into either our Center or the Department of Otorhinolaryngology of the Navy General Hospital and treated with simple HBO or GC,were used as controls.Through analyses of effective rates,cure rates and improvement rates in hearing,differences in therapeutic effects were compared between the patient group treated with HB0 combined with GC and the 2 control groups.Results The effective rate (59.52％) and improvement rate [(61.3 ± 4.7)％] for the combined treatment group were obviously higher than those of the simple HBO group[28.13％,(43.6 ± 5.5)％] and the simple hormone group [31.25％,(56.4 ± 4.1％].Conclusions The therapeutic effect of combined treatment with HBO + GC could produce good effects on refractory sudden deafness,however,adverse effects of hormones should be closely monitored in the process of the combined treatment.