CAJ | 학술논문

目的通过低压舱模拟民航客机飞行中的气压变化,并观察其对家兔胆囊结石形成的影响. 方法将48只家兔分为4组,①正常对照组(n＝12):给予标准饲料喂养;②实验组A(n＝12):0.8％胆固醇的高胆固醇饲料喂养;③实验组B(n＝12):标准饲料喂养,低气压暴露每天1次,连续28 d;④实验组C(n＝12):高胆固醇饲料喂养,低气压暴露每天1次,连续28 d.分别进行99mTc-EHIDA肝胆动态功能显像定量分析;计算各组胆囊结石发生率;并检测胆汁黏度(bile viscosity,BV)和胆汁成分(bile ingredient,BI). 结果 ①各组胆囊结石发生率,对照组为0.0％,实验组A为50.0％(6/12),实验组B为8.3％(1/12),实验组C为66.7％(8/12).②实验组A、B和C的十二指肠显影时间与对照组相比有明显的延迟(t＝4.779～17.093,P＜0.01);实验组C的十二指肠显影时间与实验组B、实验组A比较明显延迟(t＝2.693、5.654,P＜0.05或0.01).③与对照组比较,实验组A和实验组C高切变率和低切变率明显升高(t＝2.063～2.343,P＜0.05);实验组C中切变率明显高于对照组(t＝ 2.111,P＜0.05).④实验组A和实验组C总胆汁酸水平明显低于对照组和实验组B(t＝2.001～2.017,P＜0.05);实验组A和实验组C胆固醇水平明显高于对照组和实验组B(t＝2.445～2.762,P＜0.05);实验组C磷脂水平明显低于对照组和实验组B(t＝ 2.447、2.320,P＜0.05). 结论高胆固醇饲养及飞行中的气压变化对家兔的胆囊结石的形成有一定的促进作用.
목적 통과저압창모의민항객궤비행중적기압변화,병관찰기대가토담낭결석형성적영향. 방법 장48지가토분위4조,①정상대조조(n＝12):급여표준사료위양;②실험조A(n＝12):0.8％담고순적고담고순사료위양;③실험조B(n＝12):표준사료위양,저기압폭로매천1차,련속28 d;④실험조C(n＝12):고담고순사료위양,저기압폭로매천1차,련속28 d.분별진행99mTc-EHIDA간담동태공능현상정량분석;계산각조담낭결석발생솔;병검측담즙점도(bile viscosity,BV)화담즙성분(bile ingredient,BI). 결과 ①각조담낭결석발생솔,대조조위0.0％,실험조A위50.0％(6/12),실험조B위8.3％(1/12),실험조C위66.7％(8/12).②실험조A、B화C적십이지장현영시간여대조조상비유명현적연지(t＝4.779～17.093,P＜0.01);실험조C적십이지장현영시간여실험조B、실험조A비교명현연지(t＝2.693、5.654,P＜0.05혹0.01).③여대조조비교,실험조A화실험조C고절변솔화저절변솔명현승고(t＝2.063～2.343,P＜0.05);실험조C중절변솔명현고우대조조(t＝ 2.111,P＜0.05).④실험조A화실험조C총담즙산수평명현저우대조조화실험조B(t＝2.001～2.017,P＜0.05);실험조A화실험조C담고순수평명현고우대조조화실험조B(t＝2.445～2.762,P＜0.05);실험조C린지수평명현저우대조조화실험조B(t＝ 2.447、2.320,P＜0.05). 결론 고담고순사양급비행중적기압변화대가토적담낭결석적형성유일정적촉진작용.
Objective To observe the effect of cabin pressure change on gallstone formation by using hypobaric chamber to simulate hypobaric circumstance of civil aircraft in flight.Methods Forty-eight rabbits were randomly divided into control group (n＝ 12) that was with fodder,test group A (n ＝ 12) that was with 0.8％ cholesterol fodder,test group B (n ＝ 12) that was with standard fodder and hypobaric exposures 2 h a day for 28 days,and test group C (n＝12) that was with 0.8% cholesterol fodder and hypobaric exposures once a day for 28 days.The rate of gallstone formation was calculated for each group respectively.Quantitative analyses of 99 mTc-EHIDA hepatobiiiary dynamic image,the bile viscosity and bile ingredient were made for each group.Results ①The rate of gallstone formation was 0.0% in control group,50.0% in test group A (6/12),8.3％ in test group B (1/12) and 66.7％ in test group C (8/12).(②)Compared with control group,test group A,B and C showed significant delay in duodenal appearance time (DAT) (t＝4.779-17.093,P＜0.01).DAT of test group C was longer than that of test group A and test group B respectively (t＝2.693,5.654,P＜0.05 or P＜0.01).③Compared with control group,test group A and C showed higher high shear rate and low shear rate (t＝2.063 2.343,P＜0.05),and test group C had higher medium shear rate (t＝2.111,P＜0.05).(④) Compared with control group and test group B,test group A and test group C had higher level of bile acid (t 2.001 2.017,P＜0.05) and higher level of cholesterol (t＝ 2.445 2.762,P＜0.05).The level of phospholipid of test group C was lower than that of control group and test group B (t＝2.447,2.320,P＜0.05).Conclusions High cholesterol intake and barometric pressure change in flight would facilitate the gallstone formation in rabbits to some extent.