CAJ | 학술논문

目的在PD患者中建立疾病相关脑代谢网络模式(PDRP),为PD早期诊断和鉴别诊断奠定基础.方法对32例不同严重程度的PD患者和32名年龄、性别匹配的健康对照者分别行静息状态下18F-FDG PET脑显像,将2组的PET图像进行主成分分析(PCA)以获得PDRP.观察PDRP表达值与疾病严重程度[PD综合评分量表(UPDRS)运动功能评分和Hoehn&Yahr评分]之间的相关性.统计学比较采用两样本t检验和Pearson相关分析.结果 PDRP的特征表现为脑内壳核、苍白球、丘脑、脑桥、小脑和初级运动皮质的葡萄糖代谢增高,而运动前区和后顶叶的代谢相对减低.PD组的PDRP表达值明显高于对照组(1.605±0.655与0.000±0.523；t=10.829,P＜0.001),且与UPDRS运动功能评分呈明显正相关(r=0.760,P＜0.001).PDRP表达值与Hoehn&Yahr评分之间亦存在明显正相关(r=0.736,P＜0.001).结论基于18F-FDG PET显像得到的PDRP可以有效区分PD患者和健康对照者,并反映病情的严重程度.
목적 재PD환자중건립질병상관뇌대사망락모식(PDRP),위PD조기진단화감별진단전정기출.방법 대32례불동엄중정도적PD환자화32명년령、성별필배적건강대조자분별행정식상태하18F-FDG PET뇌현상,장2조적PET도상진행주성분분석(PCA)이획득PDRP.관찰PDRP표체치여질병엄중정도[PD종합평분량표(UPDRS)운동공능평분화Hoehn&Yahr평분]지간적상관성.통계학비교채용량양본t검험화Pearson상관분석.결과 PDRP적특정표현위뇌내각핵、창백구、구뇌、뇌교、소뇌화초급운동피질적포도당대사증고,이운동전구화후정협적대사상대감저.PD조적PDRP표체치명현고우대조조(1.605±0.655여0.000±0.523；t=10.829,P＜0.001),차여UPDRS운동공능평분정명현정상관(r=0.760,P＜0.001).PDRP표체치여Hoehn&Yahr평분지간역존재명현정상관(r=0.736,P＜0.001).결론 기우18F-FDG PET현상득도적PDRP가이유효구분PD환자화건강대조자,병반영병정적엄중정도.
Objective To validate PD-related pattern (PDRP) network as a measure of PD by 18F-FDG PET imaging.Methods Thirty-two PD patients with different severities and 32 healthy controls matched by age and gender were recruited in studies of resting-state brain 18F-FDG PET imaging.To obtain the PDRP,principal component analysis (PCA) was used.The correlations between PDRP expression and the severities of PD (classified by unified PD rating scale (UPDRS) motor scores and Hoehn & Yahr stages) were investigated.The two-sample t test and Pearson correlation analysis were used for statistical analysis.Results PDRP was characterized by relative metabolic increases in the putamen,globus pallidus (GP),thalamus,pons,cerebellum and primary motor cortex,and was associated with decreases in the premotor and posterior parietal areas.The value of PDRP expression in PD group (1.605±0.655) was significantly higher than that of healthy controls (0.000±0.523 ; t =10.829,P＜0.001).The value of PDRP expression also correlated significantly with UPDRS motor scores (r=0.760,P＜0.001) and Hoehn & Yahr stages in PD group (r=0.736,P＜0.001).Conclusion The PDRP based on 18F-FDG PET imaging can be useful for identification of PD patients from healthy controls and correlates well with the severity of the disease.