CAJ | 학술논문

半侧空间忽略是脑损伤后常见的一种认知功能障碍性疾病,表现为对病灶对侧或同侧空间的刺激失去反应、应答及定向能力的功能障碍.该病的诊断评估方法较多,临床常用纸笔试验,但无统一标准.其发生机制尚不清楚,普遍认同的机制为视空间注意障碍.影像学研究集中于探究引发半侧空间忽略的关键脑区.核医学显像以功能显像为优势,探测半侧空间忽略的异常脑功能区,提供异常脑功能区的血流、葡萄糖代谢、细胞活力等情况.PET在脑功能显像、分子显像方面的独特优势使其在认知功能障碍方面的应用日渐增多,为半侧空间忽略的进一步研究提供了较好的影像学方法.
반측공간홀략시뇌손상후상견적일충인지공능장애성질병,표현위대병조대측혹동측공간적자격실거반응、응답급정향능력적공능장애.해병적진단평고방법교다,림상상용지필시험,단무통일표준.기발생궤제상불청초,보편인동적궤제위시공간주의장애.영상학연구집중우탐구인발반측공간홀략적관건뇌구.핵의학현상이공능현상위우세,탐측반측공간홀략적이상뇌공능구,제공이상뇌공능구적혈류、포도당대사、세포활력등정황.PET재뇌공능현상、분자현상방면적독특우세사기재인지공능장애방면적응용일점증다,위반측공간홀략적진일보연구제공료교호적영상학방법.
Hemispatial neglect is a kind of cognitive impairment characterized by failure to report,respond or orient to stimuli presented in ipsi-or contra-lateral space after brain injury,which cannot be attributed to sensory or motor defects.Although there are various diagnosis and assessment methods,none is regarded as standard.The paper and pencil test is commonly used in routine clinical workup.The mechanism is controversial and the most accepted opinion is due to visuospatial attention defect.Imaging study focuses on exploring the functional regions leading to the hemispatial neglect.As functional imaging,SPECT and PET have capability to evaluate the perfusion,glucose metabolism and cellular vitality,which have been found increasingly useful and applicable clinically in the field of diagnosis for cognitive impairment diseases.They are likely to have potential for contribution in the study of hemispatial neglect.