CAJ | 학술논문

目的分析神经淋巴瘤病18 F-FDG PET/CT影像特征,并探讨其在评估神经淋巴瘤病中的应用价值.方法回顾性分析经病理检查证实的8例神经淋巴瘤病患者(男3例,女5例,年龄35～ 82岁)18F-FDG PET/CT影像学资料,比较神经淋巴瘤病受累周围神经与健侧周围神经PET/CT表现的异同,并利用SPSS 12.0软件对两者SUVmax行配对t检验.结果 8例神经淋巴瘤病患者PET/CT共发现病灶11个,PET示病灶均沿神经丛、神经束或椎间孔走行,表现为束条形、根块状或结节状FDG代谢异常增高,SUVmax为6.54±3.23;病灶CT表现为沿神经束或神经根管走行的束条形、根块状或结节状软组织密度影,与周围软组织及邻近脂肪间隙分界不清.健侧对应部位周围神经在18F-FDG PET/CT上未见明确显影,其SUVmax为1.15±0.48.神经淋巴瘤病受累神经与健侧周围神经SUVmax比较,差异有统计学意义(t=9.357,P＜0.001).结论神经淋巴瘤病18F-FDG PET/CT主要表现为沿神经丛、神经束或椎间孔走行的束条状、根块状或结节状FDG异常摄取灶,PET/CT可以准确反映肿瘤细胞对周围神经的浸润,显示病灶的大小、形态、分布及肿瘤活性.
목적 분석신경림파류병18 F-FDG PET/CT영상특정,병탐토기재평고신경림파류병중적응용개치.방법 회고성분석경병리검사증실적8례신경림파류병환자(남3례,녀5례,년령35～ 82세)18F-FDG PET/CT영상학자료,비교신경림파류병수루주위신경여건측주위신경PET/CT표현적이동,병이용SPSS 12.0연건대량자SUVmax행배대t검험.결과 8례신경림파류병환자PET/CT공발현병조11개,PET시병조균연신경총、신경속혹추간공주행,표현위속조형、근괴상혹결절상FDG대사이상증고,SUVmax위6.54±3.23;병조CT표현위연신경속혹신경근관주행적속조형、근괴상혹결절상연조직밀도영,여주위연조직급린근지방간극분계불청.건측대응부위주위신경재18F-FDG PET/CT상미견명학현영,기SUVmax위1.15±0.48.신경림파류병수루신경여건측주위신경SUVmax비교,차이유통계학의의(t=9.357,P＜0.001).결론 신경림파류병18F-FDG PET/CT주요표현위연신경총、신경속혹추간공주행적속조상、근괴상혹결절상FDG이상섭취조,PET/CT가이준학반영종류세포대주위신경적침윤,현시병조적대소、형태、분포급종류활성.
Objective To evaluate the imaging characteristics and value of 18F-FDG PET/CT in neurolymphomatosis.Methods Eight cases (3 males,5 females,age range: 35-82 years) with neurolymphomatosis confirmed by histopathology were included in this study.The imaging characteristics of the peripheral nerves surrounding the neurolymphoma lesions and contralateral normal tissue on 18F-FDG PET/CT were analyzed,and SUVmax was measured.Paired t test was used for data analysis by SPSS 12.0.Results Eleven lesions with increased 18F-FDG uptake in 8 cases distributed along the plexus,nerve bundle or intervertebral foramen,and shaped like bars,nodules or masses.The lesion SUVmax(6.54±3.23) was significantly higher than that of the contralateral normal peripheral nerves (1.15±0.48; t =9.357,P＜0.001).The neurolymphoma lesions on CT showed no significant density change with reference to the surrounding tissue.Conclusions The most common 18F-FDG PET/CT features of neurolymphomatosis is high 18F-FDG uptake along the neurovascular plexus,bundles or intervertebral foramina with shapes like bars,nodules or masses.18F-FDG PET/CT is a useful tool for the localization and T staging of neurolymphomatosis.