CAJ | 학술논문

儿童和青少年DTC发病率不高,但与成人DTC相比,具有一些鲜明的特征:发现时病灶体积较大,诊断时多出现颈部淋巴结或远处转移,肿瘤细胞NIS表达增高,治疗后复发率高,但总体存活率较高.术后131I治疗是治疗儿童和青少年DTC的重要手段.目前131I治疗主要采用以下3种剂量模式:不引起骨髓抑制的最大剂量,可去除病灶的特定剂量和固定剂量.
인동화청소년DTC발병솔불고,단여성인DTC상비,구유일사선명적특정:발현시병조체적교대,진단시다출현경부림파결혹원처전이,종류세포NIS표체증고,치료후복발솔고,단총체존활솔교고.술후131I치료시치료인동화청소년DTC적중요수단.목전131I치료주요채용이하3충제량모식:불인기골수억제적최대제량,가거제병조적특정제량화고정제량.
The occurrence rate of DTC in children and adolescents is not high.However,DTC in these patients has some distinct characteristics different from those in adult,such as larger tumor volume at diagnosis,early invasion of neck lymph nodes and early distant metastases,high NIS expression,high recurrence but higher overall survival rate.131 I ablation is still one of the important treatment methods after surgery.Currently,there are 3 major dosage regimens adopted for 131I treatment: prescribed dose without causing bone marrow suppression/toxicity,dose aiming at tumor ablation,and empirically fixed dose.