CAJ | 학술논문

目的探讨18F-FDG PET/CT多次显像在监测和预测NSCLC术后复发和转移中的价值.方法 NSCLC患者85例(男64例,女21例;平均年龄58.0岁),分别于术前1周内和术后3个月接受多次全身18F-FDG PET/CT显像.肿瘤复发和转移的诊断经病理学确诊或经多种影像学综合诊断并经临床随访证实.计算18F-FDG PET/CT显像的诊断效能,统计学分析采用x2检验和两独立样本t检验.结果 85例患者中,肿瘤复发和转移43例,无复发和转移42例.PET/CT在半年内检出率为9.3％ (4/43),1年内为30.2％(13/43),2年内为76.7％(33/43),2年以上为97.7％(42/43),未检出2.3％(1/43).18F-FDG PET/CT对NSCLC复发和转移的诊断灵敏度、特异性、准确性分别为97.7％(42/43)、95.2％ (40/42)和96.5％ (82/85).术前肿瘤分期、原发灶大小和原发灶SUVmax是2年内肿瘤复发和转移的影响因素(x2=12.360,t=3.281和2.465,均P＜0.05),而性别、年龄和病理类型对其则均无明显影响(x2=0.639、0.012和3.800,均P＞0.05).结论 18F-FDG PET/CT多次显像有助于监测NSCLC术后复发和转移;术前肿瘤分期、原发灶大小及原发灶SUVmax为2年内发生肿瘤复发和转移的影响因素.
목적 탐토18F-FDG PET/CT다차현상재감측화예측NSCLC술후복발화전이중적개치.방법 NSCLC환자85례(남64례,녀21례;평균년령58.0세),분별우술전1주내화술후3개월접수다차전신18F-FDG PET/CT현상.종류복발화전이적진단경병이학학진혹경다충영상학종합진단병경림상수방증실.계산18F-FDG PET/CT현상적진단효능,통계학분석채용x2검험화량독립양본t검험.결과 85례환자중,종류복발화전이43례,무복발화전이42례.PET/CT재반년내검출솔위9.3％ (4/43),1년내위30.2％(13/43),2년내위76.7％(33/43),2년이상위97.7％(42/43),미검출2.3％(1/43).18F-FDG PET/CT대NSCLC복발화전이적진단령민도、특이성、준학성분별위97.7％(42/43)、95.2％ (40/42)화96.5％ (82/85).술전종류분기、원발조대소화원발조SUVmax시2년내종류복발화전이적영향인소(x2=12.360,t=3.281화2.465,균P＜0.05),이성별、년령화병리류형대기칙균무명현영향(x2=0.639、0.012화3.800,균P＞0.05).결론 18F-FDG PET/CT다차현상유조우감측NSCLC술후복발화전이;술전종류분기、원발조대소급원발조SUVmax위2년내발생종류복발화전이적영향인소.
Objective To assess the clinical value of 18F-FDG PET/CT for the prediction of postoperative recurrence and metastasis in patients with NSCLC.Methods Eighty-five patients (64 males,21 females; average age:58.0 years) with NSCLC were enrolled.All patients underwent 18 F-FDG PET/CT within one week before surgical operation and 3 months after the operation.The diagnosis of recurrent cancer and metastasis was confirmed by pathologic findings,other imaging modalities and clinical follow-up.The diagnostic efficacy of PET/CT was calculated and the predictors for postoperative recurrence and metastasis were analyzed.x2 test and two-sample t test were used for statistical analysis.Results Among 85 patients,43 had recurrence and metastasis post operation.The postoperative recurrence and metastasis were detected by 18F-FDG PET/CT in 9.3％(4/43) within 6 months,30.2％(13/43) within 1 year,76.7％(33/43) within 2 years and 97.7％(42/43) after 2 years.The sensitivity,specificity,accuracy of 18F-FDG PET/CT for the detection of recurrent tumor and metastasis were 97.7％ (42/43),95.2％ (40/42),96.5％ (82/85) respectively.The preoperative cancer staging,size and SUVmax of primary tumor were significant factors for the prediction of postoperative tumor recurrence and metastasis within 2 years (x2 =12.360,t=3.281 and 2.465,all P＜0.05),but not gender,age or pathological findings (x2 =0.639,0.012 and 3.800,all P＞0.05).Conclusions 18F-FDG PET/CT has an important role for the detection of postoperative recurrence and metastasis in patients with NSCLC.Preoperative cancer staging,size and SUVmax of the primary tumor might be the predictive factors for postoperative tumor recurrence and metastasis within 2 years.