中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2014年
2期
86-90
,共5页
苏鸣岗%李芳兰%田蓉%李林
囌鳴崗%李芳蘭%田蓉%李林
소명강%리방란%전용%리림
癌,非小细胞肺%肿瘤转移%淋巴结%危险因素
癌,非小細胞肺%腫瘤轉移%淋巴結%危險因素
암,비소세포폐%종류전이%림파결%위험인소
Carcinoma,non-small cell lung%Neoplasm metastasis%Lymph nodes%Risk factors
目的 研究多种影响因素与NSCLC N2淋巴结转移之间的关系.方法 回顾性分析接受18F-FDG PET/CT检查和手术治疗的NSCLC患者,将其分为无N2淋巴结转移(非N2+)和有N2淋巴结转移(N2+)2组,采用x2检验或两样本t检验比较2组间性别、年龄、肿瘤部位、肿瘤大小、SUVmax、病理学类型及分化程度等影响因素的差异,然后将组间有统计学意义的影响因素及分组进行量化赋值,先后用单因素回归和多因素logistic回归分析确定对N2淋巴结转移有意义的危险因素.结果 共纳入177例患者,其中男109例,女68例,年龄(60.1±10.6)岁.非N2+(142例)和N2+(35例)2组间的肿瘤大小[(36.1±19.7) mm和(49.3±24.4) mm]、SUVmax(8.81±6.23和11.21±4.43)和分化程度(高分化:3和0例;中分化:74和11例;低分化:65和24例)差异均有统计学意义(t=-2.969和-2.633,x2=6.143,均P＜0.05),而性别、年龄、肿瘤部位和组织学类型差异均无统计学意义(x2=0.374～4.999,t=0.836,均P＞0.05).单因素分析显示,肿瘤大小、SUVmax及分化程度与N2淋巴结转移相关(r=0.201、0.245和0.185,均P＜0.05);而多因素分析示,只有SUVmax与N2淋巴结转移之间的相关性具有统计学意义(β=0.546,P＜0.01).NSCLC N2淋巴结的转移概率随着原发病灶SUVmax的增加而增加;当原发灶SUVmax≤2.5时,发生N2淋巴结转移的概率为0,而SUVmax＞7.5时概率为0.29.结论 SUVmax是NSCLC发生N2淋巴结转移的危险因素.
目的 研究多種影響因素與NSCLC N2淋巴結轉移之間的關繫.方法 迴顧性分析接受18F-FDG PET/CT檢查和手術治療的NSCLC患者,將其分為無N2淋巴結轉移(非N2+)和有N2淋巴結轉移(N2+)2組,採用x2檢驗或兩樣本t檢驗比較2組間性彆、年齡、腫瘤部位、腫瘤大小、SUVmax、病理學類型及分化程度等影響因素的差異,然後將組間有統計學意義的影響因素及分組進行量化賦值,先後用單因素迴歸和多因素logistic迴歸分析確定對N2淋巴結轉移有意義的危險因素.結果 共納入177例患者,其中男109例,女68例,年齡(60.1±10.6)歲.非N2+(142例)和N2+(35例)2組間的腫瘤大小[(36.1±19.7) mm和(49.3±24.4) mm]、SUVmax(8.81±6.23和11.21±4.43)和分化程度(高分化:3和0例;中分化:74和11例;低分化:65和24例)差異均有統計學意義(t=-2.969和-2.633,x2=6.143,均P＜0.05),而性彆、年齡、腫瘤部位和組織學類型差異均無統計學意義(x2=0.374～4.999,t=0.836,均P＞0.05).單因素分析顯示,腫瘤大小、SUVmax及分化程度與N2淋巴結轉移相關(r=0.201、0.245和0.185,均P＜0.05);而多因素分析示,隻有SUVmax與N2淋巴結轉移之間的相關性具有統計學意義(β=0.546,P＜0.01).NSCLC N2淋巴結的轉移概率隨著原髮病竈SUVmax的增加而增加;噹原髮竈SUVmax≤2.5時,髮生N2淋巴結轉移的概率為0,而SUVmax＞7.5時概率為0.29.結論 SUVmax是NSCLC髮生N2淋巴結轉移的危險因素.
목적 연구다충영향인소여NSCLC N2림파결전이지간적관계.방법 회고성분석접수18F-FDG PET/CT검사화수술치료적NSCLC환자,장기분위무N2림파결전이(비N2+)화유N2림파결전이(N2+)2조,채용x2검험혹량양본t검험비교2조간성별、년령、종류부위、종류대소、SUVmax、병이학류형급분화정도등영향인소적차이,연후장조간유통계학의의적영향인소급분조진행양화부치,선후용단인소회귀화다인소logistic회귀분석학정대N2림파결전이유의의적위험인소.결과 공납입177례환자,기중남109례,녀68례,년령(60.1±10.6)세.비N2+(142례)화N2+(35례)2조간적종류대소[(36.1±19.7) mm화(49.3±24.4) mm]、SUVmax(8.81±6.23화11.21±4.43)화분화정도(고분화:3화0례;중분화:74화11례;저분화:65화24례)차이균유통계학의의(t=-2.969화-2.633,x2=6.143,균P＜0.05),이성별、년령、종류부위화조직학류형차이균무통계학의의(x2=0.374～4.999,t=0.836,균P＞0.05).단인소분석현시,종류대소、SUVmax급분화정도여N2림파결전이상관(r=0.201、0.245화0.185,균P＜0.05);이다인소분석시,지유SUVmax여N2림파결전이지간적상관성구유통계학의의(β=0.546,P＜0.01).NSCLC N2림파결적전이개솔수착원발병조SUVmax적증가이증가;당원발조SUVmax≤2.5시,발생N2림파결전이적개솔위0,이SUVmax＞7.5시개솔위0.29.결론 SUVmax시NSCLC발생N2림파결전이적위험인소.
Objective To assess risk factors in NSCLC with N2 metastasis.Methods A total of 177 NSCLC patients (109 males,68 females; age:(60.1 ± 10.6) years) who underwent both 18F-FDG PET/CT scan and surgery were enrolled.They were divided into two groups.One was with N2 metastasis (N2+) and the other was without (non-N2+).The gender,age,location,size,primary tumor SUVmax,histopathologic type and differentiation grade between N2+ group and non-N2+ group were compared with x2 test and two-sample t test.After assignment of significant factors and groups,correlations between each factor and group were analyzed with uni-and multivariate analyses,and then the risk factors were identified finally with logistic regression analysis.Results Significant difference among factors of tumor size ((36.1±19.7) mm vs (49.3±24.4) mm),SUVmax(8.81±6.23 vs 11.21±4.43) and differentiation grades (high:3 vs 0; moderate:74 vs 11; poor:65 vs 24) were observed between non-N2+ group and N2+ group (t =-2.969,-2.633,x2 =6.143,all P＜0.05).Besides,the univariate analysis showed significant correlations between tumor size,SUVmax,differentiation grade and N2 status (r=0.201,0.245,0.185,all P＜0.05).However,multivariate logistic regression revealed that only SUVmax had a predictive value (β=0.546,P＜0.01).The incidence of N2 metastasis went up along with the increase of SUVmax.There was no N2 metastasis in the patients with SUVmax ≤2.5,and the incidence rate of metastasis increased to 0.29 in those with SUVmax＞7.5.Conclusion SUVmax may be an independent risk factor to predict N2 metastasis in NSCLC patients.
