CAJ | 학술논문

目的探讨PET/CT显像前不同准备方法对Beagle犬心肌18F-FDG生理性摄取的影响.方法取24只健康1岁龄雄性Beagle犬,按随机数字表法分为短时间(12 h)禁食加高糖(按体质量静脉注射质量分数50％葡萄糖1 g/kg) (SF-GS)组、短时间禁食(SF)组、长时间(18h)禁食(PF)组和短时间禁食加高脂餐(SF-HF)组,每组各6只犬,行18F-FDG PET/CT心肌代谢显像.图像质量分为4个等级:0级为不摄取;1级为轻度(或部分心肌)摄取;2级为心肌摄取且显像基本清晰,但不均匀;3级为心肌完全均匀摄取且显像清晰.在PET/CT融合图上选择左心室为ROI并测定SUVmax.注射18 F-FDG前进行血糖测定.评价心肌18F-FDG摄取程度,比较各组间心肌18F-FDG图像质量、SUVmax及血糖水平(注射显像剂前测定)间的差别.采用单因素方差分析、Kruskal-Wallis秩和检验进行统计分析.结果 SF-GS组心肌显像完整均匀(2级2只,3级4只),SF组心肌显像组内差异变化较大,常不均匀(2级4只,1级、3级各1只);PF组(0级3只,1级2只,2级1只)与SF-HF组(0级4只,1级2只)心肌几乎不显影;各组间心肌18F-FDG显像质量分级差异有统计学意义(H=16.83,P＜0.01).PF组SUVmax(3.01±0.97)与SF-HF组SUVmax(2.84± 1.15)明显低于SF-GS组(14.76±4.72)与SF组(10.91±2.48)(F=69.84,P＜0.01).PF组血糖水平(4.18±0.27) mmol/L与SF-HF组血糖水平(4.25±0.58) mmol/L也明显低于SF-GS组(5.80±0.56) mmol/L与SF组(4.91 ±0.51) mmol/L(F=13.58,P＜0.01).结论心肌18F-FDG显像前准备方法不同,显像结果也不同:SF-GS后,犬心肌18F-FDG摄取均匀;而PF及SF-HF后,犬心肌18F-FDG生理性摄取被抑制.
목적 탐토PET/CT현상전불동준비방법대Beagle견심기18F-FDG생이성섭취적영향.방법 취24지건강1세령웅성Beagle견,안수궤수자표법분위단시간(12 h)금식가고당(안체질량정맥주사질량분수50％포도당1 g/kg) (SF-GS)조、단시간금식(SF)조、장시간(18h)금식(PF)조화단시간금식가고지찬(SF-HF)조,매조각6지견,행18F-FDG PET/CT심기대사현상.도상질량분위4개등급:0급위불섭취;1급위경도(혹부분심기)섭취;2급위심기섭취차현상기본청석,단불균균;3급위심기완전균균섭취차현상청석.재PET/CT융합도상선택좌심실위ROI병측정SUVmax.주사18 F-FDG전진행혈당측정.평개심기18F-FDG섭취정도,비교각조간심기18F-FDG도상질량、SUVmax급혈당수평(주사현상제전측정)간적차별.채용단인소방차분석、Kruskal-Wallis질화검험진행통계분석.결과 SF-GS조심기현상완정균균(2급2지,3급4지),SF조심기현상조내차이변화교대,상불균균(2급4지,1급、3급각1지);PF조(0급3지,1급2지,2급1지)여SF-HF조(0급4지,1급2지)심기궤호불현영;각조간심기18F-FDG현상질량분급차이유통계학의의(H=16.83,P＜0.01).PF조SUVmax(3.01±0.97)여SF-HF조SUVmax(2.84± 1.15)명현저우SF-GS조(14.76±4.72)여SF조(10.91±2.48)(F=69.84,P＜0.01).PF조혈당수평(4.18±0.27) mmol/L여SF-HF조혈당수평(4.25±0.58) mmol/L야명현저우SF-GS조(5.80±0.56) mmol/L여SF조(4.91 ±0.51) mmol/L(F=13.58,P＜0.01).결론 심기18F-FDG현상전준비방법불동,현상결과야불동:SF-GS후,견심기18F-FDG섭취균균;이PF급SF-HF후,견심기18F-FDG생이성섭취피억제.
Objective To explore the effects of different pre-scan preparation protocols on the physiologic myocardial uptake of 18F-FDG in Beagle dogs.Methods Twenty-four male Beagle dogs underwent four different preparation protocols before PET/CT scans:short fasting (SF,12 h),SF followed by intravenous injection of glucose supplement (SF-GS),prolonged fasting (PF,18 h),SF followed by high fat diet (SF-HF),and each group included 6 Beagle dogs.The image quality based on 18F-FDG uptake in myocardium was assessed visually by two experienced physicians and classified into four grades:grade 0,no FDG uptake ; grade 1,faint FDG uptake; grade 2,definite FDG uptake ; grade 3,significant FDG uptake.The ROI was drawn on the myocardium of left ventricle and SUVmax was measured.The blood glucose level was measured before 18F-FDG injection.One-way analysis of variance and Kruskal-Wallis rank sum test were performed.Results In the SF-GS group,there were 2 grade 2 and 4 grade 3; while in SF group,there were 4 grade 2,1 grade 1 and 1 grade 3.In PF group,there were 3 grade 0,2 grade 1 and 1 grade 2; and in SF-HF group,there were 4 grade 0 and 2 grade 1 (H=16.83,P＜0.01).The SUVmax in PF group (3.01± 0.97) and SF-HF group (2.84±1.15) were significantly lower than those in SF-GS group (14.76±4.72) and SF group (10.91±2.48) (F=69.84,P＜0.01).The average blood glucose levels in PF group and SFHF group were significantly lower than those in SF-GS group and SF group:(4.18±0.27) mmol/L,(4.25± 0.58) mmol/L,(5.80±0.56) mmol/L,(4.91±0.51) mmol/L,respectively (F=13.58,P＜0.01).Conclusions The 18F-FDG uptake by myocardium was uniform under SF-GS protocol.PF and SF-HF protocols could suppress FDG uptake by myocardium.