中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2014年
3期
175-178
,共4页
刘玉博%史新冲%易畅%王晓燕%陈志丰%张冰%何巧%张祥松
劉玉博%史新遲%易暢%王曉燕%陳誌豐%張冰%何巧%張祥鬆
류옥박%사신충%역창%왕효연%진지봉%장빙%하교%장상송
淋巴瘤%中枢神经系统肿瘤%神经胶质瘤%NH3·H2O%脱氧葡萄糖
淋巴瘤%中樞神經繫統腫瘤%神經膠質瘤%NH3·H2O%脫氧葡萄糖
림파류%중추신경계통종류%신경효질류%NH3·H2O%탈양포도당
Lymphoma%Central nervous system neoplasms%Glioma%NH3Ⅳ·H2O%Deoxyglucose
目的 探讨13N-NH3·H2O结合18F-FDG PET/CT显像在鉴别原发性中枢神经系统淋巴瘤(PCNSL)和胶质瘤中的价值.方法 对2010年1月至2012年7月就诊的10例PCNSL患者[男7例,女3例,年龄43 ～ 74(59.10±12.47)岁]和15例胶质瘤患者[男8例,女7例,年龄14～ 72(46.73±19.61)岁]进行13N-NH3·H2O和18F-FDG PET/CT显像.以肿瘤与脑灰质摄取比(T/G)评价肿瘤的放射性摄取量.采用两样本t检验比较不同肿瘤对显像剂的摄取差异,通过判别函数分析两者联合的诊断效果.结果 PCNSL组18F-FDG的T/G值明显高于胶质瘤组,分别为3.27±1.21和1.57±0.39(t=5.630,P＜0.001),而PCNSL组13N-NH3-H2O的T/G值明显低于胶质瘤组,分别为1.43±0.26和2.12-±0.69(t=-3.551,P＜0.01).相对于13N-NH3·H2O的T/G值,所有PCNSL病灶(14个)均表现为高的18F-FDG T/G值,而77.8％(14/18)的胶质瘤病灶则显示相反的结果.利用判别函数分析,2种显像剂联合对肿瘤分类的整体准确性达96.9％(31/32),仅1例胶质瘤病灶误判为PCNSL.结论 13N-NH3·H2O联合18F-FDG有助于鉴别PCNSL和胶质瘤.
目的 探討13N-NH3·H2O結閤18F-FDG PET/CT顯像在鑒彆原髮性中樞神經繫統淋巴瘤(PCNSL)和膠質瘤中的價值.方法 對2010年1月至2012年7月就診的10例PCNSL患者[男7例,女3例,年齡43 ～ 74(59.10±12.47)歲]和15例膠質瘤患者[男8例,女7例,年齡14～ 72(46.73±19.61)歲]進行13N-NH3·H2O和18F-FDG PET/CT顯像.以腫瘤與腦灰質攝取比(T/G)評價腫瘤的放射性攝取量.採用兩樣本t檢驗比較不同腫瘤對顯像劑的攝取差異,通過判彆函數分析兩者聯閤的診斷效果.結果 PCNSL組18F-FDG的T/G值明顯高于膠質瘤組,分彆為3.27±1.21和1.57±0.39(t=5.630,P＜0.001),而PCNSL組13N-NH3-H2O的T/G值明顯低于膠質瘤組,分彆為1.43±0.26和2.12-±0.69(t=-3.551,P＜0.01).相對于13N-NH3·H2O的T/G值,所有PCNSL病竈(14箇)均錶現為高的18F-FDG T/G值,而77.8％(14/18)的膠質瘤病竈則顯示相反的結果.利用判彆函數分析,2種顯像劑聯閤對腫瘤分類的整體準確性達96.9％(31/32),僅1例膠質瘤病竈誤判為PCNSL.結論 13N-NH3·H2O聯閤18F-FDG有助于鑒彆PCNSL和膠質瘤.
목적 탐토13N-NH3·H2O결합18F-FDG PET/CT현상재감별원발성중추신경계통림파류(PCNSL)화효질류중적개치.방법 대2010년1월지2012년7월취진적10례PCNSL환자[남7례,녀3례,년령43 ～ 74(59.10±12.47)세]화15례효질류환자[남8례,녀7례,년령14～ 72(46.73±19.61)세]진행13N-NH3·H2O화18F-FDG PET/CT현상.이종류여뇌회질섭취비(T/G)평개종류적방사성섭취량.채용량양본t검험비교불동종류대현상제적섭취차이,통과판별함수분석량자연합적진단효과.결과 PCNSL조18F-FDG적T/G치명현고우효질류조,분별위3.27±1.21화1.57±0.39(t=5.630,P＜0.001),이PCNSL조13N-NH3-H2O적T/G치명현저우효질류조,분별위1.43±0.26화2.12-±0.69(t=-3.551,P＜0.01).상대우13N-NH3·H2O적T/G치,소유PCNSL병조(14개)균표현위고적18F-FDG T/G치,이77.8％(14/18)적효질류병조칙현시상반적결과.이용판별함수분석,2충현상제연합대종류분류적정체준학성체96.9％(31/32),부1례효질류병조오판위PCNSL.결론 13N-NH3·H2O연합18F-FDG유조우감별PCNSL화효질류.
Objective To investigate whether 13N-ammonia PET/CT combined with 18F-FDG PET/ CT may differentiate primary central nervous system lymphoma (PCNSL) from gliomas effectively.Methods Ten patients (7 males,3 females,age range:43-74 (59.10±12.47) years) with PCNSL and fifteen patients (8 males,7 females,age range:14-72 (46.73±19.62) years) with glioma lesions from January 2010 to July 2012 were included in this study.18F-FDG and 13N-ammonia PET/CT scans were performed in all subjects.Tumor-to-gray matter (T/G) ratios were calculated.Two-sample t test and discriminant analysis were applied to assess the differential efficacy of the two tracers.Results The T/G ratios of 18F-FDG in PCNSL lesions were higher than those in gliomas (3.27±1.21 vs 1.57±0.39,t=5.630,P＜0.001),while the T/G ratios of 13N-ammonia in PCNSL lesions were lower than those in gliomas significantly (1.43±0.26 vs 2.12±0.69,t=-3.551,P＜0.01).All PCNSL lesions (n =14) showed higher T/G ratios of 18F-FDG than those of 13 N-ammonia,whereas 77.8％ (14/18) of glioma lesions showed contrary results.Canonical discriminant analysis yielded an overall accuracy of 96.9％ (31/32) for tumor classification and only one glioma lesion was misclassified as PCNSL.Conclusion The combination of 13N-ammonia PET/CT and 18F-FDG PET/CT is helpful for differentiating PCNSL from glioma.
