CAJ | 학술논문

性腺的辐射敏感度较高.131I治疗DTC对患者生殖健康的影响备受关注.131I可导致睾丸功能的一过性损伤,表现为血清卵泡刺激素和黄体生成素升高、精子数量和活力降低,这些损伤作用与累积服用131I的活度具有相关性.131I对卵巢功能的一过性损伤表现为月经推迟、经量减少和短暂性闭经,多数在1年内恢复正常;长期损伤仅表现为绝经时间的轻度提前.现有的临床研究并未表明1311I可引发男性DTC患者的永久性不育.131I治疗1年后,女性DTC患者的受孕能力及妊娠效果并不会因既往接受过131I治疗而受到影响.
성선적복사민감도교고.131I치료DTC대환자생식건강적영향비수관주.131I가도치고환공능적일과성손상,표현위혈청란포자격소화황체생성소승고、정자수량화활력강저,저사손상작용여루적복용131I적활도구유상관성.131I대란소공능적일과성손상표현위월경추지、경량감소화단잠성폐경,다수재1년내회복정상;장기손상부표현위절경시간적경도제전.현유적림상연구병미표명1311I가인발남성DTC환자적영구성불육.131I치료1년후,녀성DTC환자적수잉능력급임신효과병불회인기왕접수과131I치료이수도영향.
For patients with DTC,the side effect of 131I therapy on fertility and offspring is an important issue since genital tissues are highly sensitive to radiation.Exposure to 131 I radiation may result in transient impairment of gonadal function in male patients caused by elevated levels of serum follicle stimulating hormone and luteinizing hormone,low sperm count and motility.In female patients,exposure to 131I radiation may be complicated with delay of menstruation,oligomenorrhea and transient cessation of menstrual period.Most of these symptoms may resolve within one year after 131 I therapy.A slightly earlier menopause is the only reported long-term side effect of 131I therapy on ovarian function.Currently available data do not indicate that exposure to 131I may cause permanent infertility in male patients with DTC.For female patients with DTC,131 I therapy does not affect fertility or pregnancy outcomes beyond one year.