中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2014年
5期
349-353
,共5页
马海彦%李思进%刘建中%武志芳%刘海燕%郭小闪%卫华%胡光%王进
馬海彥%李思進%劉建中%武誌芳%劉海燕%郭小閃%衛華%鬍光%王進
마해언%리사진%류건중%무지방%류해연%곽소섬%위화%호광%왕진
冠状动脉疾病%体层摄影术,发射型计算机,单光子%DBODC5%MIBI
冠狀動脈疾病%體層攝影術,髮射型計算機,單光子%DBODC5%MIBI
관상동맥질병%체층섭영술,발사형계산궤,단광자%DBODC5%MIBI
Coronary disease%Tomography,emission-computed,single-photon%DBODC5%MIBI
目的 探讨[二(二甲氧丙基膦基乙基)-乙氧乙胺]-[二(氧-乙氧乙基)二硫代氨基]锝氮配合物(99Tcm-N-DBODC5)对可疑冠心病患者的临床诊断价值.方法 将2010年10月至2012年10月间46例可疑冠心病患者[男31例,女15例,平均年龄60岁]按就诊先后顺序编号,同一患者随机分配进行99Tcm-N-DBODC5和99Tcm-MIBI运动-静息MPI检测冠心病及病变血管,2种显像剂的MPI在1周内完成,并在4周内行CAG.以CAG结果为“金标准”,99Tcm-N-DBODC5和99Tcm-MIBIMPI结果分别与其进行一致性检验,不同显像剂诊断效能的比较行x2检验.结果 46例可疑冠心病患者中,CAG阳性29例,阴性17例.99Tcm-N-DBODC5和99Tcm-MIBI MPI诊断冠心病的灵敏度均为86％ (25/29),特异性分别为88％(15/17)和65％(11/17),两者诊断冠心病效能差异无统计学意义(x2=2.62,P＞0.05);138支冠状动脉血管中,CAG阳性48支,阴性90支.99Tcm-N-NDBODC5与99Tcm-MIBI MPI诊断病变血管效能差异也无统计学意义(x2=3.79,P＞0.05).诊断冠心病方面,99Tcm-N-DBODC5 MPI与CAG结果的一致性较好(Kappa=0.73),99Tcm-MIBI MPI与CAG结果的一致性中等(Kappa=0.52).结论 99Tcm-N-DBODC5对冠心病患者具有一定诊断价值,可作为心肌灌注显像剂应用于临床.
目的 探討[二(二甲氧丙基膦基乙基)-乙氧乙胺]-[二(氧-乙氧乙基)二硫代氨基]锝氮配閤物(99Tcm-N-DBODC5)對可疑冠心病患者的臨床診斷價值.方法 將2010年10月至2012年10月間46例可疑冠心病患者[男31例,女15例,平均年齡60歲]按就診先後順序編號,同一患者隨機分配進行99Tcm-N-DBODC5和99Tcm-MIBI運動-靜息MPI檢測冠心病及病變血管,2種顯像劑的MPI在1週內完成,併在4週內行CAG.以CAG結果為“金標準”,99Tcm-N-DBODC5和99Tcm-MIBIMPI結果分彆與其進行一緻性檢驗,不同顯像劑診斷效能的比較行x2檢驗.結果 46例可疑冠心病患者中,CAG暘性29例,陰性17例.99Tcm-N-DBODC5和99Tcm-MIBI MPI診斷冠心病的靈敏度均為86％ (25/29),特異性分彆為88％(15/17)和65％(11/17),兩者診斷冠心病效能差異無統計學意義(x2=2.62,P＞0.05);138支冠狀動脈血管中,CAG暘性48支,陰性90支.99Tcm-N-NDBODC5與99Tcm-MIBI MPI診斷病變血管效能差異也無統計學意義(x2=3.79,P＞0.05).診斷冠心病方麵,99Tcm-N-DBODC5 MPI與CAG結果的一緻性較好(Kappa=0.73),99Tcm-MIBI MPI與CAG結果的一緻性中等(Kappa=0.52).結論 99Tcm-N-DBODC5對冠心病患者具有一定診斷價值,可作為心肌灌註顯像劑應用于臨床.
목적 탐토[이(이갑양병기련기을기)-을양을알]-[이(양-을양을기)이류대안기]득담배합물(99Tcm-N-DBODC5)대가의관심병환자적림상진단개치.방법 장2010년10월지2012년10월간46례가의관심병환자[남31례,녀15례,평균년령60세]안취진선후순서편호,동일환자수궤분배진행99Tcm-N-DBODC5화99Tcm-MIBI운동-정식MPI검측관심병급병변혈관,2충현상제적MPI재1주내완성,병재4주내행CAG.이CAG결과위“금표준”,99Tcm-N-DBODC5화99Tcm-MIBIMPI결과분별여기진행일치성검험,불동현상제진단효능적비교행x2검험.결과 46례가의관심병환자중,CAG양성29례,음성17례.99Tcm-N-DBODC5화99Tcm-MIBI MPI진단관심병적령민도균위86％ (25/29),특이성분별위88％(15/17)화65％(11/17),량자진단관심병효능차이무통계학의의(x2=2.62,P＞0.05);138지관상동맥혈관중,CAG양성48지,음성90지.99Tcm-N-NDBODC5여99Tcm-MIBI MPI진단병변혈관효능차이야무통계학의의(x2=3.79,P＞0.05).진단관심병방면,99Tcm-N-DBODC5 MPI여CAG결과적일치성교호(Kappa=0.73),99Tcm-MIBI MPI여CAG결과적일치성중등(Kappa=0.52).결론 99Tcm-N-DBODC5대관심병환자구유일정진단개치,가작위심기관주현상제응용우림상.
Objective To investigate the clinical value of 99Tcm-(bis(dimethoxypropylphosphinoethyl)-ethoxyethylamine)-(bis(N-ethoxyethyl)-dithiocarbamato nitride (99Tcm-N-DBODC5) for the detection of coronary artery disease (CAD).Methods From October 2010 to October 2012,46 patients with suspected CAD (31 males,15 females; average age:60 years) were recruited.They all underwent stressrest MPI using both 99Tcm-N-DBODC5 and 99Tcm-MIBI within l week.CAG was carried out within 1 month after MPI and chosen as the gold standard.The diagnostic accordance rate between MPI and CAG were analyzed using Kappa test.The diagnostic efficiency of 99Tcm-N-DBODC5 and 99Tcm-MIBI MPI was compared byx2 test.Results Among the 46 patients,29 were positive and 17 were negative for CAD by CAG.The sensitivity and specificity in the detection of CAD were 86％ (25/29) and 65％ (11/17) for 99Tcm-MIBI MPI,86％ (25/29) and 88％ (15/17) for 99Tcm-N-DBODC5 MPI (x2=2.62,P＞0.05),respectively.Among the 138 vessels,48 were positive and 90 were negative on CAG.The vessel-based sensitivity,specificity and accuracy for the detection of stenosis were not significantly different between 99Tcm-N-DBODC5 and 99Tcm-MIBI (x2=3.79,all P＞0.05).The accordance between 99Tcm-N-DBODC5 MPI and angiography was very good (Kappa=0.73) and moderate for 99Tcm-MIBI MPI (Kappa=0.52).Conclusion 99Tcm-N-DBODC5 might have a potential role as a MPI agent for the diagnosis of CAD.
