中华结核和呼吸杂志
中華結覈和呼吸雜誌
중화결핵화호흡잡지
Chinese Journal of Tuberculosis and Respiratory Diseases
2013年
1期
33-37
,共5页
张芝娇%朱航%蒲昫頔%张帆%雷迅%周文洁%汪洋
張芝嬌%硃航%蒲昫頔%張帆%雷迅%週文潔%汪洋
장지교%주항%포구적%장범%뢰신%주문길%왕양
结核%肿瘤坏死因子-α%多态性,单核苷酸%疾病易感性%Meta分析
結覈%腫瘤壞死因子-α%多態性,單覈苷痠%疾病易感性%Meta分析
결핵%종류배사인자-α%다태성,단핵감산%질병역감성%Meta분석
Tuberculosis%Tumor necrosis factor-alpha%Polymorphism,single nucleotide%Disease susceptibility%Meta-analysis
目的 综合评价肿瘤坏死因子(TNF)-α-238基因多态性与结核易感性的关系.方法 以tuberculosis、TB、mycobacteria、polymorphism、variant、mutation、susceptibility、tumor necrosis factoror、TNF、cytokine和gene为检索词,检索Pubmed、Embase、Web of science、ScienceDirect、SpringerLink和EBSCO数据库.以结核、肿瘤坏死因子、基因、多态性、细胞因子、易感性、敏感性、相关性、关联性为中文检索词,检索万方数据、中国知网中文数据库.所有数据库检索时间截止2011年10月底.检验各组Hardy-Weinberg遗传平衡定律,评估各研究结果的异质性及发表偏倚.结果 本研究共纳入9篇病例对照研究,荟萃分析结果表明,TNF-α-238基因型(GA+ AA/GG和A/G)在各组的分布差异均无统计学意义(OR值均为1.00,95％ CI为0.77 ～ 1.32).未见显著异质性(Q值分别为5.04和5.82,均P＞0.05).无发表偏倚(Begg检验,Z值分别为0.73和0.52；Egger检验,t值分别为1.94和1.72,均P＞0.05).敏感度分析结果表明,本研究结果的稳定性较好(OR值为0.94 ～ 1.10,均P＞0.05).结论 TNF-α-238基因多态性与结核病易感性无显著关联性.
目的 綜閤評價腫瘤壞死因子(TNF)-α-238基因多態性與結覈易感性的關繫.方法 以tuberculosis、TB、mycobacteria、polymorphism、variant、mutation、susceptibility、tumor necrosis factoror、TNF、cytokine和gene為檢索詞,檢索Pubmed、Embase、Web of science、ScienceDirect、SpringerLink和EBSCO數據庫.以結覈、腫瘤壞死因子、基因、多態性、細胞因子、易感性、敏感性、相關性、關聯性為中文檢索詞,檢索萬方數據、中國知網中文數據庫.所有數據庫檢索時間截止2011年10月底.檢驗各組Hardy-Weinberg遺傳平衡定律,評估各研究結果的異質性及髮錶偏倚.結果 本研究共納入9篇病例對照研究,薈萃分析結果錶明,TNF-α-238基因型(GA+ AA/GG和A/G)在各組的分佈差異均無統計學意義(OR值均為1.00,95％ CI為0.77 ～ 1.32).未見顯著異質性(Q值分彆為5.04和5.82,均P＞0.05).無髮錶偏倚(Begg檢驗,Z值分彆為0.73和0.52；Egger檢驗,t值分彆為1.94和1.72,均P＞0.05).敏感度分析結果錶明,本研究結果的穩定性較好(OR值為0.94 ～ 1.10,均P＞0.05).結論 TNF-α-238基因多態性與結覈病易感性無顯著關聯性.
목적 종합평개종류배사인자(TNF)-α-238기인다태성여결핵역감성적관계.방법 이tuberculosis、TB、mycobacteria、polymorphism、variant、mutation、susceptibility、tumor necrosis factoror、TNF、cytokine화gene위검색사,검색Pubmed、Embase、Web of science、ScienceDirect、SpringerLink화EBSCO수거고.이결핵、종류배사인자、기인、다태성、세포인자、역감성、민감성、상관성、관련성위중문검색사,검색만방수거、중국지망중문수거고.소유수거고검색시간절지2011년10월저.검험각조Hardy-Weinberg유전평형정률,평고각연구결과적이질성급발표편의.결과 본연구공납입9편병례대조연구,회췌분석결과표명,TNF-α-238기인형(GA+ AA/GG화A/G)재각조적분포차이균무통계학의의(OR치균위1.00,95％ CI위0.77 ～ 1.32).미견현저이질성(Q치분별위5.04화5.82,균P＞0.05).무발표편의(Begg검험,Z치분별위0.73화0.52；Egger검험,t치분별위1.94화1.72,균P＞0.05).민감도분석결과표명,본연구결과적은정성교호(OR치위0.94 ～ 1.10,균P＞0.05).결론 TNF-α-238기인다태성여결핵병역감성무현저관련성.
Objective A comprehensive meta-analysis was performed to investigate the relationship between TNF-238G/A polymorphism and tuberculosis susceptibility.Methods Tuberculosis,TB,mycobacteria,polymorphism,variant,mutation,susceptibility,tumor necrosis factoror,TNF,cytokine,and gene were used as key words both in Chinese and English to search all the published related articles in Pubmed,Embase,Web of science,Science Direct,Springer Link,EBSCO,Wanfang and Chinese Journal Full-text Database until October 2011.HWE test was performed in all the comparisons.Heterogeneity across studies was determined,and sensitivity analyses were conducted.Results Nine case-control studies were included.The meta-analysis indicated that there was no significant association between TNF-238G/A polymorphism and tuberculosis susceptibility (GA + AA vs GG model:OR =1.00,95％ CI:O.77-1.32 ; A vs G model:OR =1.00,95％ CI:0.77-1.30).No significant heterogeneity (Q was 5.04 and 5.82 respectively,P ＞ 0.05) and publication bias (GA + AA vs GG model:Begg test Z =0.73,Egger test t =1.94,P ＞ 0.05 ; A vs G model:Begg test Z =0.52,Egger test t =1.72,P ＞ 0.05) were demonstrated.Sensitivity analyses further indicated the reliability of the study (OR were O.94-1.10 respectively,all P ＞0.05).Conclusion Our study did not detect any association between TNF-238G/A polymorphism and tuberculosis susceptibility.
