中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2012年
5期
268-273
,共6页
易正辉%张晨%李则挚%卢卫红%杜亚松%范娟%汪栋祥%刘漪%傅迎美%方贻儒%禹顺英
易正輝%張晨%李則摯%盧衛紅%杜亞鬆%範娟%汪棟祥%劉漪%傅迎美%方貽儒%禹順英
역정휘%장신%리칙지%로위홍%두아송%범연%왕동상%류의%부영미%방이유%우순영
精神分裂症%脑源性神经营养因子%多态性,单核苷酸
精神分裂癥%腦源性神經營養因子%多態性,單覈苷痠
정신분렬증%뇌원성신경영양인자%다태성,단핵감산
Schizophrenia%Brain-derived neurotrophic factor%Polymorphism,single nucleotide
目的 探讨中国汉族人群脑源性神经营养因子(BDNF)基因rs11030101和rs6265多态性与早发精神分裂症的关联性.方法 采用TaqMan法,检测360例早发精神分裂症患者(患者组,起病年龄＜18岁)和399名健康对照(对照组)BDNF基因rs11030101及rs6265 2个多态位点,并对等位基因、基因型及单体型频率进行比较.结果 (1)患者组与对照组rs11030101等位基因分布和基因型分布的差异均有统计学意义[x2 =5.13,自由度(df)=1,P=0.024;x2=6.12,df=2,P=0.047],但经Bonferroni校正检验后,只有等位基因分布的差异有统计学意义(P =0.048)；单体型分析显示,患者组与对照组A-Val及T-Val分布的差异有统计学意义(x2=7.96,P=0.005;x2=8.53,P =0.004).(2)在女性人群中,患者组与对照组rs11030101基因型分布的差异有统计学意义(x2=7.76,df=2,P=0.021),经Bonferroni校正检验后差异仍有统计学意义(P=0.042)；单体型T-Val及T-Met分布的差异均有统计学意义(x2=6.90,P=0.009；x2=4.60,P=0.032).结论 在中国汉族人群中BDNF基因可能与早发精神分裂症存在关联,尤其与女性早发精神分裂症存在关联,其可能是女性早发精神分裂症的易患基因.
目的 探討中國漢族人群腦源性神經營養因子(BDNF)基因rs11030101和rs6265多態性與早髮精神分裂癥的關聯性.方法 採用TaqMan法,檢測360例早髮精神分裂癥患者(患者組,起病年齡＜18歲)和399名健康對照(對照組)BDNF基因rs11030101及rs6265 2箇多態位點,併對等位基因、基因型及單體型頻率進行比較.結果 (1)患者組與對照組rs11030101等位基因分佈和基因型分佈的差異均有統計學意義[x2 =5.13,自由度(df)=1,P=0.024;x2=6.12,df=2,P=0.047],但經Bonferroni校正檢驗後,隻有等位基因分佈的差異有統計學意義(P =0.048)；單體型分析顯示,患者組與對照組A-Val及T-Val分佈的差異有統計學意義(x2=7.96,P=0.005;x2=8.53,P =0.004).(2)在女性人群中,患者組與對照組rs11030101基因型分佈的差異有統計學意義(x2=7.76,df=2,P=0.021),經Bonferroni校正檢驗後差異仍有統計學意義(P=0.042)；單體型T-Val及T-Met分佈的差異均有統計學意義(x2=6.90,P=0.009；x2=4.60,P=0.032).結論 在中國漢族人群中BDNF基因可能與早髮精神分裂癥存在關聯,尤其與女性早髮精神分裂癥存在關聯,其可能是女性早髮精神分裂癥的易患基因.
목적 탐토중국한족인군뇌원성신경영양인자(BDNF)기인rs11030101화rs6265다태성여조발정신분렬증적관련성.방법 채용TaqMan법,검측360례조발정신분렬증환자(환자조,기병년령＜18세)화399명건강대조(대조조)BDNF기인rs11030101급rs6265 2개다태위점,병대등위기인、기인형급단체형빈솔진행비교.결과 (1)환자조여대조조rs11030101등위기인분포화기인형분포적차이균유통계학의의[x2 =5.13,자유도(df)=1,P=0.024;x2=6.12,df=2,P=0.047],단경Bonferroni교정검험후,지유등위기인분포적차이유통계학의의(P =0.048)；단체형분석현시,환자조여대조조A-Val급T-Val분포적차이유통계학의의(x2=7.96,P=0.005;x2=8.53,P =0.004).(2)재녀성인군중,환자조여대조조rs11030101기인형분포적차이유통계학의의(x2=7.76,df=2,P=0.021),경Bonferroni교정검험후차이잉유통계학의의(P=0.042)；단체형T-Val급T-Met분포적차이균유통계학의의(x2=6.90,P=0.009；x2=4.60,P=0.032).결론 재중국한족인군중BDNF기인가능여조발정신분렬증존재관련,우기여녀성조발정신분렬증존재관련,기가능시녀성조발정신분렬증적역환기인.
Objective To investigate the relationship between the brain-derived neurotrophic factor (BDNF) gene Tag SNPs (rs11030101 and rs6265) and early-onset schizophrenia in the Chinese Han population.Methods The tag single nucleotide polymorphisms(tag SNPs) rs11030101 and rs6265 in the BDNF gene wcrc genotypcd in 360 early-onset schizophrenics and 399 controls subjects.Single nucleotide polymorphism association and haplotype analysis were performed.Results (1) There were significantly difference in allele and genotype frequencies between patients and control subjects for rs11030101 (x2 =5.13,df=1,P=0.024; x2 =6.12,df=2,P =0.047) and haplotypes A-Val and T-Val (x2 =7.96,P =0.005 ;x2 =8.53,P =0.004),and the difference in allele frequencies was still statistically significant after Bonferroni correction (P =0.048).(2) Stratification of the study by gender of the samples yielded significant evidence for an association with the polymorphisms rs11030101 in female population (genotypewise:x2 =7.76,df=2,P =0.021),and the difference still existed after Bonferroni correction(P=0.042).The haplotype analysis revealed that there was significant differences between patients and control subjects for haplotypes T-Val and T-Met (x2 =6.90,P =0.009 ; x2 =4.60,P =0.032) in the female population.Conclusions The BDNF gene may play important roles in the susceptibility to early-onset and female schizophrenia in the Chinese population.
