中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2012年
6期
321-326
,共6页
刘琳琳%王惠玲%王熇生%苏德振%陈诚%吴士豪%杨灿%王高华%牛海晶%蒋田仔
劉琳琳%王惠玲%王熇生%囌德振%陳誠%吳士豪%楊燦%王高華%牛海晶%蔣田仔
류림림%왕혜령%왕고생%소덕진%진성%오사호%양찬%왕고화%우해정%장전자
精神分裂症%额叶前皮质%谱学,近红外线%伦敦塔
精神分裂癥%額葉前皮質%譜學,近紅外線%倫敦塔
정신분렬증%액협전피질%보학,근홍외선%륜돈탑
Sehizophrenia%Prefrontal cortex%Spectroscopy,near-infrared%Tower of London
目的 比较精神分裂症患者与健康人在不同难度等级伦敦塔(the Tower of London,TOL)认知任务下的脑区激活程度和模式的差异.方法 利用功能性近红外光谱成像技术(functional near infrared spectroscopy,fNIRS),记录30例精神分裂症患者(患者组)和30名健康对照(对照组)在fNIRS仪不同难度等级的TOL任务下双侧前额叶皮质血红蛋白浓度的变化;以阳性与阴性症状量表评分评定患者组的精神症状.结果 (1)患者组较对照组在各难度等级的TOL测验上的正确答题数少,反应时间长(P均<0.05).(2)激活程度比较:患者组在各难度等级TOL任务下前额叶皮质激活均弱于对照组(P<0.05).(3)激活模式比较:中间的前额叶皮质:对照组的激活程度为中等任务>容易任务>困难任务[容易、中等及困难任务期氧合血红蛋白的差值(△oxy-Hb)分别为4.05±4.89、5.93±3.94、2.12±1.78,P<0.05],患者组不同难度TOL任务下激活程度差异无统计学意义(P>0.05);背外侧前额叶皮质:对照组不同难度TOL任务下激活程度差异无统计学意义(P>0.05),患者组随着任务难度的增加其激活程度降低(容易、中等及困难任务期△oxy-Hb分别为5.19±9.12、3.14±6.74、0.01±0.82,P <0.05).结论 精神分裂症患者存在前额叶功能低下,其在任务状态下的激活模式与健康人不同.
目的 比較精神分裂癥患者與健康人在不同難度等級倫敦塔(the Tower of London,TOL)認知任務下的腦區激活程度和模式的差異.方法 利用功能性近紅外光譜成像技術(functional near infrared spectroscopy,fNIRS),記錄30例精神分裂癥患者(患者組)和30名健康對照(對照組)在fNIRS儀不同難度等級的TOL任務下雙側前額葉皮質血紅蛋白濃度的變化;以暘性與陰性癥狀量錶評分評定患者組的精神癥狀.結果 (1)患者組較對照組在各難度等級的TOL測驗上的正確答題數少,反應時間長(P均<0.05).(2)激活程度比較:患者組在各難度等級TOL任務下前額葉皮質激活均弱于對照組(P<0.05).(3)激活模式比較:中間的前額葉皮質:對照組的激活程度為中等任務>容易任務>睏難任務[容易、中等及睏難任務期氧閤血紅蛋白的差值(△oxy-Hb)分彆為4.05±4.89、5.93±3.94、2.12±1.78,P<0.05],患者組不同難度TOL任務下激活程度差異無統計學意義(P>0.05);揹外側前額葉皮質:對照組不同難度TOL任務下激活程度差異無統計學意義(P>0.05),患者組隨著任務難度的增加其激活程度降低(容易、中等及睏難任務期△oxy-Hb分彆為5.19±9.12、3.14±6.74、0.01±0.82,P <0.05).結論 精神分裂癥患者存在前額葉功能低下,其在任務狀態下的激活模式與健康人不同.
목적 비교정신분렬증환자여건강인재불동난도등급륜돈탑(the Tower of London,TOL)인지임무하적뇌구격활정도화모식적차이.방법 이용공능성근홍외광보성상기술(functional near infrared spectroscopy,fNIRS),기록30례정신분렬증환자(환자조)화30명건강대조(대조조)재fNIRS의불동난도등급적TOL임무하쌍측전액협피질혈홍단백농도적변화;이양성여음성증상량표평분평정환자조적정신증상.결과 (1)환자조교대조조재각난도등급적TOL측험상적정학답제수소,반응시간장(P균<0.05).(2)격활정도비교:환자조재각난도등급TOL임무하전액협피질격활균약우대조조(P<0.05).(3)격활모식비교:중간적전액협피질:대조조적격활정도위중등임무>용역임무>곤난임무[용역、중등급곤난임무기양합혈홍단백적차치(△oxy-Hb)분별위4.05±4.89、5.93±3.94、2.12±1.78,P<0.05],환자조불동난도TOL임무하격활정도차이무통계학의의(P>0.05);배외측전액협피질:대조조불동난도TOL임무하격활정도차이무통계학의의(P>0.05),환자조수착임무난도적증가기격활정도강저(용역、중등급곤난임무기△oxy-Hb분별위5.19±9.12、3.14±6.74、0.01±0.82,P <0.05).결론 정신분렬증환자존재전액협공능저하,기재임무상태하적격활모식여건강인불동.
Objective To investigate the executive function as well as the characteristics of the activation in the prefrontal cortex (PFC) of schizophrenia patients during the graded Tower of London test.Methods Near-infrared spectroscopy (NIRS) was used to assess hemoglobin concentration changes in the bilateral PFCs during the TOL tasks (at different levels of difficulty) in 30 schizophrenia patients and 30 age-and gender-matched healthy controls.The Positive and Negative Syndrome Scale (PANSS) was used to assess the psychiatric symptoms of the patients.Results (1) The numbers of the correct answers of all the three difficulty levels of TOL in the schizophrenia group were less than that of the control group,while the response time were longer than that of the latter.(2) The majority of the prcfrontal areas of the normal controls were significantly activated during TOL task.And compared with the controls,the patients were characterized by significant decreased activation in the bilateral PFC during all levels of the TOL tasks (P <0.05).(3) The activation patterns of the two groups were different.The activations in middle areas of the prefrontal cortex in the normal controls were medium > easy > difficult (the △oxy-Hb of easy,medium and difficult were 4.05 ±4.89,5.93 ±3.94 and 2.12 ± 1.78 respectively,P <0.05).In the patients,there was no significant difference among the different levels of TOL (P > 0.05).There was no differences on activations in dorsolateral prefrontal cortex in the normal controls among the different levels of TOL (P >0.05),while for the patients,with the increasing of the difficulty of the TOL tasks,the activations were reduced instead (the Aoxy-Hb of easy,medium and difficult were 5.19 ± 9.12,3.14 ± 6.74 and 0.01 ±0.82 respectively,P < 0.05).Conclusion Schizophrenia patients have executive dysfunction,which may be explained by PFC dysfunction.The results further support that schizophrenia patients have hypofrontality,and different activation model during executive tasks.