中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2012年
6期
331-334
,共4页
宋梓祥%陈琪%徐乐平%李宁%李光耀%徐大明%潘佳%仲爱芳%汪广剑%孙剑%余海鹰%王焕林
宋梓祥%陳琪%徐樂平%李寧%李光耀%徐大明%潘佳%仲愛芳%汪廣劍%孫劍%餘海鷹%王煥林
송재상%진기%서악평%리저%리광요%서대명%반가%중애방%왕엄검%손검%여해응%왕환림
氯氮平%氟哌啶醇%精神分裂症%体重%神经肽Y%瘦素
氯氮平%氟哌啶醇%精神分裂癥%體重%神經肽Y%瘦素
록담평%불고정순%정신분렬증%체중%신경태Y%수소
Clozapine%Haloperidol%Schizophrenia%Body weight%Neuropeptide Y%Leptin
目的 探讨氯氮平与氟哌啶醇治疗对精神分裂症患者体质量、神经肽Y和瘦素的影响及其相互关系.方法 采用随机排列表法,将符合《中国精神障碍分类与诊断标准》第3版精神分裂症诊断标准的60例精神分裂症患者分为氯氮平组和氟哌啶醇组,每组各30例,分别接受氯氮平[250～400(323 ±53) mg/d]和氟哌啶醇[10～20(14±3) mg/d]治疗,并于基线,治疗第3、6周末,测定2组的体质量、血浆神经肽Y和瘦素水平.结果 (1)治疗第3、6周末,氯氮平组体质量[(58.9±10.1)、(61.0±10.3)kg]和神经肽Y[(50.4 ±20.2)、(67.8 ±27.2) ng/L]均高于基线[(57.6±9.9)kg,(39.2±15.7) ng/L],差异有统计学意义(F=9.531,P=0.009;F =37.395,P=0.000;F=7.947,P=0.015;F=22.689,P=0.000),治疗第6周末瘦素[(7.6±4.3)ng/L]显著高于基线[(4.9±2.7) ng/L;F=6.376,P=0.027]；氟哌啶醇组各时点体质量(F=0.350,P=0.708)、神经肽Y(F=0.075,P=0.789)和瘦素(F=0.089,P=0.915)比较差异无统计学意义.(2)氯氮平组和氟哌啶醇组各时点体质量(F =6.341,P=0.004)、神经肽Y(F=14.565,P=0.000)和瘦素(F=6.088,P=0.005)存在组别×时间的交互作用.(3)治疗第6周末,氯氮平组体质量变化率与神经肽Y变化率正性相关(r =0.715,P=0.006).结论 氯氮平治疗过程中伴有神经肽Y、瘦素升高和体质量增加,且神经肽Y的升高与体质量增加相关.
目的 探討氯氮平與氟哌啶醇治療對精神分裂癥患者體質量、神經肽Y和瘦素的影響及其相互關繫.方法 採用隨機排列錶法,將符閤《中國精神障礙分類與診斷標準》第3版精神分裂癥診斷標準的60例精神分裂癥患者分為氯氮平組和氟哌啶醇組,每組各30例,分彆接受氯氮平[250～400(323 ±53) mg/d]和氟哌啶醇[10～20(14±3) mg/d]治療,併于基線,治療第3、6週末,測定2組的體質量、血漿神經肽Y和瘦素水平.結果 (1)治療第3、6週末,氯氮平組體質量[(58.9±10.1)、(61.0±10.3)kg]和神經肽Y[(50.4 ±20.2)、(67.8 ±27.2) ng/L]均高于基線[(57.6±9.9)kg,(39.2±15.7) ng/L],差異有統計學意義(F=9.531,P=0.009;F =37.395,P=0.000;F=7.947,P=0.015;F=22.689,P=0.000),治療第6週末瘦素[(7.6±4.3)ng/L]顯著高于基線[(4.9±2.7) ng/L;F=6.376,P=0.027]；氟哌啶醇組各時點體質量(F=0.350,P=0.708)、神經肽Y(F=0.075,P=0.789)和瘦素(F=0.089,P=0.915)比較差異無統計學意義.(2)氯氮平組和氟哌啶醇組各時點體質量(F =6.341,P=0.004)、神經肽Y(F=14.565,P=0.000)和瘦素(F=6.088,P=0.005)存在組彆×時間的交互作用.(3)治療第6週末,氯氮平組體質量變化率與神經肽Y變化率正性相關(r =0.715,P=0.006).結論 氯氮平治療過程中伴有神經肽Y、瘦素升高和體質量增加,且神經肽Y的升高與體質量增加相關.
목적 탐토록담평여불고정순치료대정신분렬증환자체질량、신경태Y화수소적영향급기상호관계.방법 채용수궤배렬표법,장부합《중국정신장애분류여진단표준》제3판정신분렬증진단표준적60례정신분렬증환자분위록담평조화불고정순조,매조각30례,분별접수록담평[250～400(323 ±53) mg/d]화불고정순[10～20(14±3) mg/d]치료,병우기선,치료제3、6주말,측정2조적체질량、혈장신경태Y화수소수평.결과 (1)치료제3、6주말,록담평조체질량[(58.9±10.1)、(61.0±10.3)kg]화신경태Y[(50.4 ±20.2)、(67.8 ±27.2) ng/L]균고우기선[(57.6±9.9)kg,(39.2±15.7) ng/L],차이유통계학의의(F=9.531,P=0.009;F =37.395,P=0.000;F=7.947,P=0.015;F=22.689,P=0.000),치료제6주말수소[(7.6±4.3)ng/L]현저고우기선[(4.9±2.7) ng/L;F=6.376,P=0.027]；불고정순조각시점체질량(F=0.350,P=0.708)、신경태Y(F=0.075,P=0.789)화수소(F=0.089,P=0.915)비교차이무통계학의의.(2)록담평조화불고정순조각시점체질량(F =6.341,P=0.004)、신경태Y(F=14.565,P=0.000)화수소(F=6.088,P=0.005)존재조별×시간적교호작용.(3)치료제6주말,록담평조체질량변화솔여신경태Y변화솔정성상관(r =0.715,P=0.006).결론 록담평치료과정중반유신경태Y、수소승고화체질량증가,차신경태Y적승고여체질량증가상관.
Objective To investigate the changes of neuropeptide Y(NPY),leptin,body weight and their relationship in schizophrenics with clozapine and haloperidol treatment.Methods Thirty schizophrenic patients treated with clozapine [250-400 (323 ± 53) mg/d] and 30 patients treated with haloperidol [10-20 (14 ± 3) mg/d] were involved in the study.Body weight and plasma NPY,leptin levels were measured at weeks 0 and 3,6.Results (1) The body weight and plasma NPY levels in clozapine group increased significantly at 3 weekend[(58.9 ± 10.1) kg,(50.4 ±20.2) ng/L] and 6 weekend [(61.0 ± 10.3) kg,(67.8 ± 27.2) ng/L] compared to those before the treatment [(57.6 ± 9.9) kg,(39.2 ± 15.7) ng/L](F=9.531,P=0.009;F=37.395,P=0.000;F=7.947,P=0.015;F=22.689,P=0.000),while leptin levels increased significantly at 6 weekend [(7.6 ±4.3) ng/L] compared to baseline [(4.9 ±2.7)ng/L;F =6.376,P =0.027].The differences on body weight(F =0.350,P =0.708) and plasma NPY (F =0.075,P =0.789),leptin levels (F =0.089,t =0.915) at each timepoint in haloperidol group were not significant.(2) The altering tendency of body weight (F = 6.341,P =0.004) and plasma NPY (F =14.565,P =0.000),leptin levels (F =6.088,P =0.005) at each timepoint were significantly different in both groups,there were interactions between groups and time.(3) In clozapine group,the altering rate of body weight at 6th weekend was positively correlated with that of plasma NPY levels (r =0.715,P =0.006).Conclusion The data indicates that NPY and leptin be elevated and body weight increased in the treatment with clozapine,moreover,the increasing of NPY have a significant relationship with that of body weight.
