中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2012年
6期
354-358
,共5页
宋美%许顺江%于鲁璐%王岚%李和军%安翠霞%张富%封俊杰%贾海玲%李凝%刘可智%王学义
宋美%許順江%于魯璐%王嵐%李和軍%安翠霞%張富%封俊傑%賈海玲%李凝%劉可智%王學義
송미%허순강%우로로%왕람%리화군%안취하%장부%봉준걸%가해령%리응%류가지%왕학의
老年人%生活变动事件%轻度认知功能损害
老年人%生活變動事件%輕度認知功能損害
노년인%생활변동사건%경도인지공능손해
Aged%Life change events%Mild cognitive impairment
目的 探讨重大生活事件对年龄≥60岁老年人认知功能及轻度认知损害(MCI)患病倾向性的影响.方法 采用认知评估及生活事件问卷调查对3098名年龄≥60岁老年被试者进行评估,筛选1307例MCI倾向(MCI倾向组)和1092名正常对照(对照组),通过分析生活事件在2组老年人的暴露情况来探讨其对认知功能及MCI患病倾向的影响.结果 丧失配偶[x2=55.131,OR=2.416,95％可信区间(CI)=1.905 ～ 3.063]、丧失父母子女(x2=13.570,OR=1.355,95％CI=1.153 ～1.594),经济困难(x2=41.490,OR=1.990,95％CI=1.610 ～2.459),意外事故(x2=19.669,OR=1.513,95％CI=1.259 ～1.818)与MCI患病倾向性有明显相关性(P＜0.01)；而财产损失及犯罪事件(x2=5.249,OR=1.605,95％CI=1.067 ～2.413)和其他生活事件(x2=4.305,OR=1.400,95％ CI=1.018～ 1.925)与MCI患病倾向性有关(P＜0.05)；离异(x2=0.377,OR =0.754,95％CI=0.305 ～1.863)和失业(x2 =3.559,OR=1.524,95％CI =0.981～2.368)与MCI患病倾向无明显相关(P＞0.05).Logistic多元回归分析显示,年龄、经济困难、意外事故和其他生活事件对MCI患病倾向有显著影响(P＜0.01)；受教育程度可能对MCI患病倾向有保护作用(β=～1.236,SE=0.074,Wald=278.597,OR =0.290,95％ CI =0.251～0.336).MCI倾向性比率随着经历生活事件的个数而增加.结论 部分生活事件可能是导致老年人认知功能损害的危险因素.
目的 探討重大生活事件對年齡≥60歲老年人認知功能及輕度認知損害(MCI)患病傾嚮性的影響.方法 採用認知評估及生活事件問捲調查對3098名年齡≥60歲老年被試者進行評估,篩選1307例MCI傾嚮(MCI傾嚮組)和1092名正常對照(對照組),通過分析生活事件在2組老年人的暴露情況來探討其對認知功能及MCI患病傾嚮的影響.結果 喪失配偶[x2=55.131,OR=2.416,95％可信區間(CI)=1.905 ～ 3.063]、喪失父母子女(x2=13.570,OR=1.355,95％CI=1.153 ～1.594),經濟睏難(x2=41.490,OR=1.990,95％CI=1.610 ～2.459),意外事故(x2=19.669,OR=1.513,95％CI=1.259 ～1.818)與MCI患病傾嚮性有明顯相關性(P＜0.01)；而財產損失及犯罪事件(x2=5.249,OR=1.605,95％CI=1.067 ～2.413)和其他生活事件(x2=4.305,OR=1.400,95％ CI=1.018～ 1.925)與MCI患病傾嚮性有關(P＜0.05)；離異(x2=0.377,OR =0.754,95％CI=0.305 ～1.863)和失業(x2 =3.559,OR=1.524,95％CI =0.981～2.368)與MCI患病傾嚮無明顯相關(P＞0.05).Logistic多元迴歸分析顯示,年齡、經濟睏難、意外事故和其他生活事件對MCI患病傾嚮有顯著影響(P＜0.01)；受教育程度可能對MCI患病傾嚮有保護作用(β=～1.236,SE=0.074,Wald=278.597,OR =0.290,95％ CI =0.251～0.336).MCI傾嚮性比率隨著經歷生活事件的箇數而增加.結論 部分生活事件可能是導緻老年人認知功能損害的危險因素.
목적 탐토중대생활사건대년령≥60세노년인인지공능급경도인지손해(MCI)환병경향성적영향.방법 채용인지평고급생활사건문권조사대3098명년령≥60세노년피시자진행평고,사선1307례MCI경향(MCI경향조)화1092명정상대조(대조조),통과분석생활사건재2조노년인적폭로정황래탐토기대인지공능급MCI환병경향적영향.결과 상실배우[x2=55.131,OR=2.416,95％가신구간(CI)=1.905 ～ 3.063]、상실부모자녀(x2=13.570,OR=1.355,95％CI=1.153 ～1.594),경제곤난(x2=41.490,OR=1.990,95％CI=1.610 ～2.459),의외사고(x2=19.669,OR=1.513,95％CI=1.259 ～1.818)여MCI환병경향성유명현상관성(P＜0.01)；이재산손실급범죄사건(x2=5.249,OR=1.605,95％CI=1.067 ～2.413)화기타생활사건(x2=4.305,OR=1.400,95％ CI=1.018～ 1.925)여MCI환병경향성유관(P＜0.05)；리이(x2=0.377,OR =0.754,95％CI=0.305 ～1.863)화실업(x2 =3.559,OR=1.524,95％CI =0.981～2.368)여MCI환병경향무명현상관(P＞0.05).Logistic다원회귀분석현시,년령、경제곤난、의외사고화기타생활사건대MCI환병경향유현저영향(P＜0.01)；수교육정도가능대MCI환병경향유보호작용(β=～1.236,SE=0.074,Wald=278.597,OR =0.290,95％ CI =0.251～0.336).MCI경향성비솔수착경력생활사건적개수이증가.결론 부분생활사건가능시도치노년인인지공능손해적위험인소.
Objective To explore the effects of severe life events on the cognitive function and tendency of mild cognitive impairment (MCI) in elderly people.Methods The cognitive function and life events of 3098 people aged 60 years or above were assessed,and 1307 with MCI tendency and 1092 normal controls were selected out.Results Spouse death (x2 =55.131,OR =2.416,95％CI=1.905-3.063),parents and children's death (x2 =13.570,OR =1.355,95％ CI =1.153-1.594),financial difficulties (x2 =41.490,OR =1.990,95％ CI =1.610-2.459) and accidents and disasters (x2 =19.669,OR =1.513,95％ CI =1.259-1.818) were significantly relevant to cognitive dysfunction and MCI tendency (P ＜0.01).Property loss and criminal experiences(x2 =5.249,OR =1.605,95％ CI =1.067-2.413)and other life events (x2 =4.305,OR =1.400,95％ CI =1.018-1.925) were relevant to cognitive dysfunction and MCI tendency (P ＜ 0.05),however,divorce (x2 =0.377,OR =0.754,95％ CI =0.305-1.863) and unemployment (x2 =3.559,OR =1.524,95％ CI=0.981-2.368) might not be relevant to MCI tendency (P ＞0.05).The logistic multiple regression analysis showed that age,education,financial difficulties,accidents and disasters and other life events were the related factors to the tendency of MCI (P ＜ 0.01).Conclusions Some severe life events might be the risk factors of elderly cognitive impairment.
