CAJ | 학술논문

目的探讨多巴胺受体基因与遇到吸毒和社会支持的环境因素及其交互作用对海洛因依赖者戒断后复吸的影响.方法采用一般情况调查表、自然病程问卷、社会支持评定量表,收集249例海洛因依赖者戒断后1年的一般社会人口学资料、戒断后1年遇到吸毒相关环境情况、社会支持等信息,其中复吸者(复吸组)111例,保持操守者(操守组)138例；采用TaqMan探针基因分型技术对所有复吸组和操守组的多巴胺D2受体基因(DRD2)的13个单核苷酸多态性位点进行基因分型检测；采用广义多因子降维(generalized muhifactor dimensionality reduction)统计软件检测影响海洛因依赖复吸的基因-环境交互作用.结果 (1)复吸组在过去1年中经常遇到吸毒相关环境的频率显著高于操守组(32％∶3％；F =68.15,P＜0.01),社会支持量表得分显著低于操守组[(26.83±5.54)分:(28.99±4.44)分；t=3.41,P＜0.01]；(2)DRD2基因与过去1年遇到吸毒相关环境情况及社会支持水平之间存在交互作用(检验样本准确度为0.79,P＜0.01).结论吸毒相关环境及社会支持水平与海洛因戒断后复吸相关；DRD2基因与遇到吸毒相关环境、社会支持水平之间可能存在交互作用,并共同影响海洛因依赖戒断后1年内复吸行为的发生.
목적 탐토다파알수체기인여우도흡독화사회지지적배경인소급기교호작용대해락인의뢰자계단후복흡적영향.방법 채용일반정황조사표、자연병정문권、사회지지평정량표,수집249례해락인의뢰자계단후1년적일반사회인구학자료、계단후1년우도흡독상관배경정황、사회지지등신식,기중복흡자(복흡조)111례,보지조수자(조수조)138례；채용TaqMan탐침기인분형기술대소유복흡조화조수조적다파알D2수체기인(DRD2)적13개단핵감산다태성위점진행기인분형검측；채용엄의다인자강유(generalized muhifactor dimensionality reduction)통계연건검측영향해락인의뢰복흡적기인-배경교호작용.결과 (1)복흡조재과거1년중경상우도흡독상관배경적빈솔현저고우조수조(32％∶3％；F =68.15,P＜0.01),사회지지량표득분현저저우조수조[(26.83±5.54)분:(28.99±4.44)분；t=3.41,P＜0.01]；(2)DRD2기인여과거1년우도흡독상관배경정황급사회지지수평지간존재교호작용(검험양본준학도위0.79,P＜0.01).결론 흡독상관배경급사회지지수평여해락인계단후복흡상관；DRD2기인여우도흡독상관배경、사회지지수평지간가능존재교호작용,병공동영향해락인의뢰계단후1년내복흡행위적발생.
Objective To understand the role of the dopamine D2 receptor gene (DRD2),encountering drug-related environmental situations and social support over the previous year for relapse in heroin dependence.Methods Information was collected from 249 heroin dependent patients at one year after abstinent by using the Natural History Interview,Social Support Rateing Scale,and other questionnaires.These questionnaires provided demographic data,drug-related environmental situations and the social support over the previous year.Thirteen tagSNPs polymorphisms on DRD2 were genotyped by TaqMan SNP genotyping assay for all participants.Generalized multifactor dimensionality reduction (GMDR) was used to construct the gene-environment interaction model which impacting relapse in heroin dependence.Results The relapse group had higher frequencies of encountering drug-related environment (32％ vs.3％ ; F =68.15,P ＜ 0.01) and less Social Support Scale scores (26.83± 5.54 vs.28.99 ±4.44;t =3.41,P ＜ 0.01) than that in the abstinence group in the previous year.Gene-environment interaction of GMDR analysis showed that the DRD2 gene was interact with the frequency of encountering drug-related environment and social support level to impact the relapse in heroin dependence (P ＜ 0.01).Conclusion The relapse of heroin dependence after treatment is related to the frequency of encountering drug-related environment,and social support.Gene-environment interaction between DRD2 gene and the frequency of encountering drug-related environment and social support may be related to heroin dependence relapse.