中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2013年
2期
71-77
,共7页
蚁金瑶%钟明天%朱熊兆%王湘%廖坚%姚树桥
蟻金瑤%鐘明天%硃熊兆%王湘%廖堅%姚樹橋
의금요%종명천%주웅조%왕상%료견%요수교
抑郁症%磁共振成像%杏仁核%负性认知加工%脑功能连接%认知易感者
抑鬱癥%磁共振成像%杏仁覈%負性認知加工%腦功能連接%認知易感者
억욱증%자공진성상%행인핵%부성인지가공%뇌공능련접%인지역감자
Depressive disorder%Magnetic resonance imaging%Amygdala%Negative cognitive processing%Functional connectivity%Cognitive vulnerability
目的 探讨抑郁认知易感者和抑郁症患者在负性情绪信息加工过程中杏仁核与不同脑区之问是否具有特殊的脑功能连接方式.方法 使用认知方式问卷筛查得到抑郁认知易感者(易感组,26例)与非易感者(对照组,31名),选取同期临床抑郁症患者(抑郁症组,29例),分别完成情绪面孔匹配任务,同步进行功能磁共振扫描；采用功能连接方法比较各组杏仁核与不同脑区之间的功能连接差异.结果 易感组的杏仁核与右侧额中回之间的功能连接比对照组弱[蒙特利尔神经研究所(MNI):26,40,-12;t =3.88,P＜0.001,k=10],抑郁症组杏仁核与左侧额下回之间的功能连接比对照组弱(MNI:-46,24,-12;t =4.20,P＜0.001,k=16).结论 在面对负性刺激时,抑郁认知易感者和抑郁症患者杏仁核与前额叶之间的功能连接降低.
目的 探討抑鬱認知易感者和抑鬱癥患者在負性情緒信息加工過程中杏仁覈與不同腦區之問是否具有特殊的腦功能連接方式.方法 使用認知方式問捲篩查得到抑鬱認知易感者(易感組,26例)與非易感者(對照組,31名),選取同期臨床抑鬱癥患者(抑鬱癥組,29例),分彆完成情緒麵孔匹配任務,同步進行功能磁共振掃描；採用功能連接方法比較各組杏仁覈與不同腦區之間的功能連接差異.結果 易感組的杏仁覈與右側額中迴之間的功能連接比對照組弱[矇特利爾神經研究所(MNI):26,40,-12;t =3.88,P＜0.001,k=10],抑鬱癥組杏仁覈與左側額下迴之間的功能連接比對照組弱(MNI:-46,24,-12;t =4.20,P＜0.001,k=16).結論 在麵對負性刺激時,抑鬱認知易感者和抑鬱癥患者杏仁覈與前額葉之間的功能連接降低.
목적 탐토억욱인지역감자화억욱증환자재부성정서신식가공과정중행인핵여불동뇌구지문시부구유특수적뇌공능련접방식.방법 사용인지방식문권사사득도억욱인지역감자(역감조,26례)여비역감자(대조조,31명),선취동기림상억욱증환자(억욱증조,29례),분별완성정서면공필배임무,동보진행공능자공진소묘；채용공능련접방법비교각조행인핵여불동뇌구지간적공능련접차이.결과 역감조적행인핵여우측액중회지간적공능련접비대조조약[몽특리이신경연구소(MNI):26,40,-12;t =3.88,P＜0.001,k=10],억욱증조행인핵여좌측액하회지간적공능련접비대조조약(MNI:-46,24,-12;t =4.20,P＜0.001,k=16).결론 재면대부성자격시,억욱인지역감자화억욱증환자행인핵여전액협지간적공능련접강저.
Objective To examine the patterns of the functional connectivity between the amygdala and other brain regions in subjects with cognitive vulnerability and subjects with major depressive disorder while processing negative information.Methods Using the cognitive style questionnaire (CSQ) and some psychological scales,subjects with cognitive vulnerability (CV,26 subjects) and healthy control subjects (HC,31 subjects) were recruited.Besides,first-episode treatment-free subjects with major depressive disorder (MDD,29 subjects) from outpatients in the psychology clinic were included.All subjects were scanned by functional magnetic resonance imaging (fMRI) while performing an emotional matching task.The functional connectivity patterns between the amygdala and other brain regions were examined for each group.Results The right middle frontal gyrus showed less connectivity with the amygdala in subjects with CV than in HC subjects [Montreal Neurological Institute (MNI):26,40,-12 ; t =3.88,P ＜ 0.001,k =10].The left inferior frontal gyrus showed decreased connectivity with amygdala in MDD patients compared with HC subjects (MNI:-46,24,-12; t =4.20,P＜0.001,k=16).Conclusion When viewing negative stimuli,the functional connectivity between the amygdala and the prefrontal cortex is decreased in individuals with CV and MDD.
