中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2013年
2期
90-93
,共4页
徐乐平%潘园园%汪莉%宋梓祥%纪菊英%陈琪%周菲菲%孙剑%赵汉清
徐樂平%潘園園%汪莉%宋梓祥%紀菊英%陳琪%週菲菲%孫劍%趙漢清
서악평%반완완%왕리%송재상%기국영%진기%주비비%손검%조한청
运动障碍,药物性%精神分裂症%铁%磁共振成像
運動障礙,藥物性%精神分裂癥%鐵%磁共振成像
운동장애,약물성%정신분렬증%철%자공진성상
Dyskinesia,drug-induced%Schizophrenia%Iron%Magnetic resonance imaging
目的 探讨伴与不伴迟发性运动障碍(TD)的精神分裂症患者及正常健康人脑铁沉积与TD的关系.方法 采用磁敏感加权成像技术,测定TD患者(TD组,14名)、非TD患者(非TD组,14例)和正常健康人(对照组,14名)黑质、尾状核等基底节灰质核团的校正相位值(CP)；采用异常不自主运动量表(AIMS)评定TD症状.结果 (1)调整年龄、性别因素后,TD组黑质、尾状核CP值分别为(-0.207±0.029)、(-0.097 ±0.021)rad,非TD组分别为(-0.166±0.031)、(-0.075±0.014) rad,对照组分别为(-0.142±0.033)、(-0.081 ±0.017)rad；TD组低于非TD组(d=0.041,0.022;P =0.001,0.001)和对照组(d=0.064,0.015; P=0.000,0.027)；非TD组黑质CP值低于对照组(d=0.024,P=0.043),差异均有统计学意义.(2)TD组尾状核CP值与AIMS严重程度评分负相关(rs=-0.508,P=0.025)；Logistic回归分析显示,黑质、尾状核CP值低(β=-76.869,P=0.026;β=-185.876,P=0.042)、年龄高(β=0.388,P=0.055)与TD的发生有关.结论 TD患者基底节存在过量脑铁沉积,并与TD发生可能存在一定的联系.
目的 探討伴與不伴遲髮性運動障礙(TD)的精神分裂癥患者及正常健康人腦鐵沉積與TD的關繫.方法 採用磁敏感加權成像技術,測定TD患者(TD組,14名)、非TD患者(非TD組,14例)和正常健康人(對照組,14名)黑質、尾狀覈等基底節灰質覈糰的校正相位值(CP)；採用異常不自主運動量錶(AIMS)評定TD癥狀.結果 (1)調整年齡、性彆因素後,TD組黑質、尾狀覈CP值分彆為(-0.207±0.029)、(-0.097 ±0.021)rad,非TD組分彆為(-0.166±0.031)、(-0.075±0.014) rad,對照組分彆為(-0.142±0.033)、(-0.081 ±0.017)rad；TD組低于非TD組(d=0.041,0.022;P =0.001,0.001)和對照組(d=0.064,0.015; P=0.000,0.027)；非TD組黑質CP值低于對照組(d=0.024,P=0.043),差異均有統計學意義.(2)TD組尾狀覈CP值與AIMS嚴重程度評分負相關(rs=-0.508,P=0.025)；Logistic迴歸分析顯示,黑質、尾狀覈CP值低(β=-76.869,P=0.026;β=-185.876,P=0.042)、年齡高(β=0.388,P=0.055)與TD的髮生有關.結論 TD患者基底節存在過量腦鐵沉積,併與TD髮生可能存在一定的聯繫.
목적 탐토반여불반지발성운동장애(TD)적정신분렬증환자급정상건강인뇌철침적여TD적관계.방법 채용자민감가권성상기술,측정TD환자(TD조,14명)、비TD환자(비TD조,14례)화정상건강인(대조조,14명)흑질、미상핵등기저절회질핵단적교정상위치(CP)；채용이상불자주운동량표(AIMS)평정TD증상.결과 (1)조정년령、성별인소후,TD조흑질、미상핵CP치분별위(-0.207±0.029)、(-0.097 ±0.021)rad,비TD조분별위(-0.166±0.031)、(-0.075±0.014) rad,대조조분별위(-0.142±0.033)、(-0.081 ±0.017)rad；TD조저우비TD조(d=0.041,0.022;P =0.001,0.001)화대조조(d=0.064,0.015; P=0.000,0.027)；비TD조흑질CP치저우대조조(d=0.024,P=0.043),차이균유통계학의의.(2)TD조미상핵CP치여AIMS엄중정도평분부상관(rs=-0.508,P=0.025)；Logistic회귀분석현시,흑질、미상핵CP치저(β=-76.869,P=0.026;β=-185.876,P=0.042)、년령고(β=0.388,P=0.055)여TD적발생유관.결론 TD환자기저절존재과량뇌철침적,병여TD발생가능존재일정적련계.
Objective To investigate the difference of brain iron deposition among schizophrenia with or without tardive dyskinesia (TD),and healthy volunteers,so as to explore its relationship with pathogenesis of TD.Methods Susceptibility weighted imaging MRI findings were studied in 14 schizophrenic patients with TD,14 schizophrenic patients without TD,and 14 healthy controls.The corrected phase (CP) of basal ganglia including substantia nigra (SN),caudate nucleus (CN) were measured.The Abnormal Involuntary Movement Scale (AIMS) was used for evaluating the clinical status of TD.Results After adjusting for age,sex,the mean CP of SN and CN were significantly decreased in TD patients [(-0.207 ± 0.029),(-0.097 ± 0.021) rad] compared to non-TD patients [(-0.166 ± 0.031),(-0.075 ±0.014) rad; d =0.041,0.022; both P =0.001] and healthy subjects [(-0.142 ± 0.033),(-0.081 ± 0.017) rad ; d =0.064,0.015 ; P =0.000,0.027],while the mean CP of SN was significantly lower in non-TD patients than that in healthy subjects(d =0.024,P =0.043).Decreased mean CP of CN correlated with higher severity score of AIMS in TD patients (rs =-0.508,P =0.025).Logistic regression analysis showed that the decreased CP value in SN (β =-76.869,P =0.026)and CN (β =-185.876,P =0.042),aging (β =0.388,P =0.055) were associated with the onset of TD.Conclusions The results indicate the increase in iron accumulation in basal ganglia may be associated with pathogenesis of TD in schizophrenic patients.
