中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2013年
2期
104-108
,共5页
孙达亮%邱春%蔡亦蕴%王志阳%施慎逊%管一晖%华逢春
孫達亮%邱春%蔡亦蘊%王誌暘%施慎遜%管一暉%華逢春
손체량%구춘%채역온%왕지양%시신손%관일휘%화봉춘
疑病症%脑%正电子发射断层显像术
疑病癥%腦%正電子髮射斷層顯像術
의병증%뇌%정전자발사단층현상술
Hypochondriasis%Brain%Positron emission tomography
目的 探讨疑病症患者脑葡萄糖代谢的变化特点.方法 对符合《中国精神障碍分类与诊断标准(第3版)》中疑病症诊断标准的11例患者(疑病症组)与年龄、性别相匹配的23名对照(对照组)进行脑氟-18脱氧葡萄糖正电子发射断层显像,将脑部图像数据与统计参数图的模板进行空间归一化后分析2组受试者脑葡萄糖代谢的差异.结果 与对照组比较,疑病症组右角回及顶下小叶(Z=4.72)、右岛叶(Z=4.19)、右额中央前回(Z=4.15)和中央旁小叶(Z=3.52)、右顶叶楔前回(Z=4.09)、右额中回(Z=3.39)和额下回(Z=3.79)、左后扣带回(Z=3.95)、左顶叶楔前回(Z=3.98)、左额中央前回(Z=3.72)、双侧丘脑及中脑、豆状核葡萄糖代谢增高(Z≥3.94)；右颞上回(Z=4.05)、右额叶直回(Z=3.93)、右额上回(Z=3.14)、左额叶直回(Z=3.59)葡萄糖代谢明显减低(P均＜0.001).结论 疑病症患者存在多处脑区葡萄糖代谢异常.
目的 探討疑病癥患者腦葡萄糖代謝的變化特點.方法 對符閤《中國精神障礙分類與診斷標準(第3版)》中疑病癥診斷標準的11例患者(疑病癥組)與年齡、性彆相匹配的23名對照(對照組)進行腦氟-18脫氧葡萄糖正電子髮射斷層顯像,將腦部圖像數據與統計參數圖的模闆進行空間歸一化後分析2組受試者腦葡萄糖代謝的差異.結果 與對照組比較,疑病癥組右角迴及頂下小葉(Z=4.72)、右島葉(Z=4.19)、右額中央前迴(Z=4.15)和中央徬小葉(Z=3.52)、右頂葉楔前迴(Z=4.09)、右額中迴(Z=3.39)和額下迴(Z=3.79)、左後釦帶迴(Z=3.95)、左頂葉楔前迴(Z=3.98)、左額中央前迴(Z=3.72)、雙側丘腦及中腦、豆狀覈葡萄糖代謝增高(Z≥3.94)；右顳上迴(Z=4.05)、右額葉直迴(Z=3.93)、右額上迴(Z=3.14)、左額葉直迴(Z=3.59)葡萄糖代謝明顯減低(P均＜0.001).結論 疑病癥患者存在多處腦區葡萄糖代謝異常.
목적 탐토의병증환자뇌포도당대사적변화특점.방법 대부합《중국정신장애분류여진단표준(제3판)》중의병증진단표준적11례환자(의병증조)여년령、성별상필배적23명대조(대조조)진행뇌불-18탈양포도당정전자발사단층현상,장뇌부도상수거여통계삼수도적모판진행공간귀일화후분석2조수시자뇌포도당대사적차이.결과 여대조조비교,의병증조우각회급정하소협(Z=4.72)、우도협(Z=4.19)、우액중앙전회(Z=4.15)화중앙방소협(Z=3.52)、우정협설전회(Z=4.09)、우액중회(Z=3.39)화액하회(Z=3.79)、좌후구대회(Z=3.95)、좌정협설전회(Z=3.98)、좌액중앙전회(Z=3.72)、쌍측구뇌급중뇌、두상핵포도당대사증고(Z≥3.94)；우섭상회(Z=4.05)、우액협직회(Z=3.93)、우액상회(Z=3.14)、좌액협직회(Z=3.59)포도당대사명현감저(P균＜0.001).결론 의병증환자존재다처뇌구포도당대사이상.
Objective To investigate the brain glucose metabolism in hypochondriasis with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) compared with health subjects.Methods Eleven patients diagnosed as hypochondriasis according to CCMD-3 criteria and 23 age-and sex-matched healthy subjects were performed FDG PET/CT scan.All FDG-PET images were spatially normalized using statistical parametric mapping (SPM8; http://www.fil.ion.ucl.ac.uk/spm/) with an original template of SPM.Then the study analyzed the differences between the two groups to compare regarding respective FDG metabolism.Results Voxel-wise comparison of FDG-PET images was conducted using SPM8 to identify the brain regions showing glucose hypermetabolism in the right angular gyrus and inferior parietal lobule (Z =4.72),right insula (Z =4.19),right precentral gyrus (Z =4.15) and paracentral lobule (Z =3.52),right precuneate gyrus (Z =4.09),right middle (Z =3.39) and inferior frontal gyrus (Z =3.79),left posterior cingulate (Z =3.95),left precuneate gyrus (Z =3.98),left precentral gyrus (Z =3.72),bilateral thalamus,mesencephalon and lentiform nucleus (Z≥3.94).In addition,glucose hypometabolism was found in the fight superior temporal gyrus (Z =4.05),right gyrusrectus (Z =3.93),right superior frontal gyrus(Z =3.14) and left gyrusrectus(Z =3.59) in comparison with that of the normal subjects(P ＜ 0.001).Conclusions Hypochondriasis patients could have abnormal glucose metabolism in multiple regions of brain,which may involve the regulation of the pathophysiology in the central nervous system.
