中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2013年
3期
132-136
,共5页
肖湘%肖婷%肖朝勇%刘文%梁凤晶%肖舟%柴学%邹冰%沈继英
肖湘%肖婷%肖朝勇%劉文%樑鳳晶%肖舟%柴學%鄒冰%瀋繼英
초상%초정%초조용%류문%량봉정%초주%시학%추빙%침계영
孤独性障碍%磁共振成像%弥散张量成像%脑白质%髓鞘化
孤獨性障礙%磁共振成像%瀰散張量成像%腦白質%髓鞘化
고독성장애%자공진성상%미산장량성상%뇌백질%수초화
Autistic disorder%Magnetic resonance imaging%Diffusion tensor imaging%White matter%Myelination
目的 对比分析幼儿期孤独障碍儿童的脑白质髓鞘化程度.方法 对28例孤独障碍儿童和28例年龄、性别、智商与之相匹配的发育障碍儿童(对照组)进行T2加权磁共振成像扫描和扩散张量成像扫描,采用影像科医生定性评价与计算髓鞘化程度值(J值)、各向异性分数(FA)定量评价相结合的方法,对比两组间关键脑区白质的髓鞘化程度的差异.结果 影像科医生定性评价未显示2组间存在显著的髓鞘化程度差异(P均＞0.05).但进行定量评价时,与对照组相比,孤独障碍组儿童的右侧第一二脑回区、中央后回及左侧额极区的J值降低(1028.75±449.60比1344.51±580.30,1050.19±456.78比1335.10±593.69,1103.68±543.38比1491.80±590.48),差异有统计学意义(t=-0.533,1.308,-0.104;P均＜0.05)；左侧第一二脑回区及右侧额极区的FA值更低(0.234±0.052比0.279±0.069,0.224±0.069比0.251±0.057),差异有统计学意义(t=-2.276,2.545;P均＜0.05).结论 幼儿期孤独障碍儿童的不同脑区脑白质髓鞘化程度存在异常,额叶和顶叶的髓鞘化程度较低.
目的 對比分析幼兒期孤獨障礙兒童的腦白質髓鞘化程度.方法 對28例孤獨障礙兒童和28例年齡、性彆、智商與之相匹配的髮育障礙兒童(對照組)進行T2加權磁共振成像掃描和擴散張量成像掃描,採用影像科醫生定性評價與計算髓鞘化程度值(J值)、各嚮異性分數(FA)定量評價相結閤的方法,對比兩組間關鍵腦區白質的髓鞘化程度的差異.結果 影像科醫生定性評價未顯示2組間存在顯著的髓鞘化程度差異(P均＞0.05).但進行定量評價時,與對照組相比,孤獨障礙組兒童的右側第一二腦迴區、中央後迴及左側額極區的J值降低(1028.75±449.60比1344.51±580.30,1050.19±456.78比1335.10±593.69,1103.68±543.38比1491.80±590.48),差異有統計學意義(t=-0.533,1.308,-0.104;P均＜0.05)；左側第一二腦迴區及右側額極區的FA值更低(0.234±0.052比0.279±0.069,0.224±0.069比0.251±0.057),差異有統計學意義(t=-2.276,2.545;P均＜0.05).結論 幼兒期孤獨障礙兒童的不同腦區腦白質髓鞘化程度存在異常,額葉和頂葉的髓鞘化程度較低.
목적 대비분석유인기고독장애인동적뇌백질수초화정도.방법 대28례고독장애인동화28례년령、성별、지상여지상필배적발육장애인동(대조조)진행T2가권자공진성상소묘화확산장량성상소묘,채용영상과의생정성평개여계산수초화정도치(J치)、각향이성분수(FA)정량평개상결합적방법,대비량조간관건뇌구백질적수초화정도적차이.결과 영상과의생정성평개미현시2조간존재현저적수초화정도차이(P균＞0.05).단진행정량평개시,여대조조상비,고독장애조인동적우측제일이뇌회구、중앙후회급좌측액겁구적J치강저(1028.75±449.60비1344.51±580.30,1050.19±456.78비1335.10±593.69,1103.68±543.38비1491.80±590.48),차이유통계학의의(t=-0.533,1.308,-0.104;P균＜0.05)；좌측제일이뇌회구급우측액겁구적FA치경저(0.234±0.052비0.279±0.069,0.224±0.069비0.251±0.057),차이유통계학의의(t=-2.276,2.545;P균＜0.05).결론 유인기고독장애인동적불동뇌구뇌백질수초화정도존재이상,액협화정협적수초화정도교저.
Objective To assess the myelination degrees of white matter between infants with autistic disorder and developmental disorder (DD).Methods Scoring by image doctors combined with computing divergence index value and fractional anisotropy value of 18 areas was applied to the T2 weighted images and diffusion tensor images of 28 children with autistic disorder and 28 children with DD.Results There was no significant difference in the scores of myelination degrees between the two groups.Compared with children with DD,the divergence index value in right convolution Ⅰ-Ⅱ and right postrolandic area of children with autistic disorder were significantly lower(1028.75 ±449.60 vs.1344.51 ± 580.30,1050.19 ± 456.78 vs.1335.10 ± 593.69,1103.68 ± 543.38 vs.1491.80 ± 590.48,t =-0.533,1.308,-0.104; all P ＜ 0.05).Significant decrease of FA value were also present in left convolution Ⅰ-Ⅱ and right frontal lobe polar(0.234 ± 0.052 vs.0.279 ± 0.069,0.224 ± 0.069 vs.0.251 ± 0.057,t =-2.276,2.545 ; all P ＜ 0.05).Conclusion The findings indicate myelination degrees in frontal and parietal lobe are abnormal in children with autistic disorder.
