中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2013年
3期
153-157
,共5页
黄环环%何凡%程宇航%梁月竹%崔永华%杨建红%贾军朴%郑毅
黃環環%何凡%程宇航%樑月竹%崔永華%楊建紅%賈軍樸%鄭毅
황배배%하범%정우항%량월죽%최영화%양건홍%가군박%정의
多动秽语综合征%受体,多巴胺D2%多态性,单核苷酸%治疗效果
多動穢語綜閤徵%受體,多巴胺D2%多態性,單覈苷痠%治療效果
다동예어종합정%수체,다파알D2%다태성,단핵감산%치료효과
Tourette syndrome%Receptors,dopamine D2%Polymorphism,single nucleotide%Treatment outcome
目的 探讨Tourette综合征(TS)疗效与多巴胺D2受体(DRD2)基因单核苷酸多态性(SNP)位点rs 1800497多态分布频率的相关性.方法 应用TaqMan探针SNP基因分型技术,对非难治性TS组(74例)和难治性TS组(91例)患者DRD2基因SNP位点rs1800497进行基因分型；根据自制的临床资料调查表和耶鲁综合抽动严重程度量表收集患者临床资料,使用《美国精神障碍诊断与统计手册(第4版)》TS诊断标准进行诊断.结果 非难治性TS组与难治性TS组DRD2基因SNP位点rs1800497基因型(非难治性TS组:C/C、C/T、T/T的频率分别为16.2％、47.3％、36.5％,难治性TS组C/C、C/T、T/T频率分别为20.9％、51.6％、27.5％)及等位基因(非难治性TS组C和T的频率分别为39.9％、60.1％,难治性TS组C和T的频率分别为46.7％、53.3％)频率分布差异无统计学意义(x2=1.680,1.552;P均＞0.05).结论 DRD2基因SNP位点rs1800497多态分布频率可能与Tourette综合征药物疗效无关联.
目的 探討Tourette綜閤徵(TS)療效與多巴胺D2受體(DRD2)基因單覈苷痠多態性(SNP)位點rs 1800497多態分佈頻率的相關性.方法 應用TaqMan探針SNP基因分型技術,對非難治性TS組(74例)和難治性TS組(91例)患者DRD2基因SNP位點rs1800497進行基因分型；根據自製的臨床資料調查錶和耶魯綜閤抽動嚴重程度量錶收集患者臨床資料,使用《美國精神障礙診斷與統計手冊(第4版)》TS診斷標準進行診斷.結果 非難治性TS組與難治性TS組DRD2基因SNP位點rs1800497基因型(非難治性TS組:C/C、C/T、T/T的頻率分彆為16.2％、47.3％、36.5％,難治性TS組C/C、C/T、T/T頻率分彆為20.9％、51.6％、27.5％)及等位基因(非難治性TS組C和T的頻率分彆為39.9％、60.1％,難治性TS組C和T的頻率分彆為46.7％、53.3％)頻率分佈差異無統計學意義(x2=1.680,1.552;P均＞0.05).結論 DRD2基因SNP位點rs1800497多態分佈頻率可能與Tourette綜閤徵藥物療效無關聯.
목적 탐토Tourette종합정(TS)료효여다파알D2수체(DRD2)기인단핵감산다태성(SNP)위점rs 1800497다태분포빈솔적상관성.방법 응용TaqMan탐침SNP기인분형기술,대비난치성TS조(74례)화난치성TS조(91례)환자DRD2기인SNP위점rs1800497진행기인분형；근거자제적림상자료조사표화야로종합추동엄중정도량표수집환자림상자료,사용《미국정신장애진단여통계수책(제4판)》TS진단표준진행진단.결과 비난치성TS조여난치성TS조DRD2기인SNP위점rs1800497기인형(비난치성TS조:C/C、C/T、T/T적빈솔분별위16.2％、47.3％、36.5％,난치성TS조C/C、C/T、T/T빈솔분별위20.9％、51.6％、27.5％)급등위기인(비난치성TS조C화T적빈솔분별위39.9％、60.1％,난치성TS조C화T적빈솔분별위46.7％、53.3％)빈솔분포차이무통계학의의(x2=1.680,1.552;P균＞0.05).결론 DRD2기인SNP위점rs1800497다태분포빈솔가능여Tourette종합정약물료효무관련.
Objective To explore the difference of rs1800497 of single nucleotide polymorphism (SNP) of dopamine D2 receptor (DRD2) gene genotype and allele frequency in Tourette syndrome (TS) patients with different therapeutic effect in Chinese Han population.Methods The rs1800497 polymorphism of the DRD2 gene was genotyped by TaqMan SNP genotyping assay technique.The clinical data and tic symptoms was assessed with the clinical data schedule table and the Yale Global Tie Severity Scale.TS was diagnosed with the Diagnostic and Statistical Manual of Mental Disorder,the Forth Edition diagnostic criteria for Tourette syndrome.Results The frequencies of the DRD2 gene rs1800497 polymorphism C/C,C/T and T/T genotypes were 16.2％,47.3％,and 36.5％ in non-refractory TS group and 20.9％,51.6％,and 27.5％ in refractory TS group.The allelic frequencies of rs1800497 polymorphism C and T were 39.9％ and 60.1％ in non-refractory TS group and 46.7％ and 53.3％ in refractory TS group.There was no significant differences in the frequencies of genotype and allele for the rs1800497 polymorphism of DRD2 gene between non-refractory TS group(74 samples)and refractory TS group (91 samples) (x2 =1.680,1.552;P ＞0.05).Conclusions The rs1800497 polymorphism of DRD2 gene may be not associated with TS patients with different therapeutic effect.
