中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2013年
4期
204-211
,共8页
胡强%万玉美%苏亮%李惠%金一%李婷%王继军%李春波%张明园
鬍彊%萬玉美%囌亮%李惠%金一%李婷%王繼軍%李春波%張明園
호강%만옥미%소량%리혜%금일%리정%왕계군%리춘파%장명완
焦虑症%患病率%Meta分析%中国
焦慮癥%患病率%Meta分析%中國
초필증%환병솔%Meta분석%중국
Anxiety disorders%Prevalence%Meta-analysis%China
目的 评价中国普通人群1982-2012年焦虑障碍患病率及其在性别、年龄、城乡、婚姻状况、教育程度、调研年代、诊断标准等不同因素间的差别.方法 检索EMBASE、PubMed和中国期刊全文数据库、万方数字化期刊全文数据库、中国科技期刊数据库(维普)、中国生物医学文献数据库等,并辅以文献追溯方法,收集1982-2012年在国内外公开发表的所有关于中国人群焦虑障碍患病率的研究文献,依照事先定义的纳入及排除标准进行筛选,并根据观察性研究的报告标准评价文献质量,采用R-2.15.0软件对资料间异质性检验、敏感性分析、合并患病率及发表偏倚评估进行Meta分析.结果 共25项研究196 020人纳入分析.焦虑障碍时点患病率为1.0％[95％可信区间(CI)0.7％～1.4％],12个月患病率为4.5％(95％CI2.7％ ～7.5％),终生患病率为3.2％ (95％ CI 2.1％～4.7％).以时点患病率计,广泛性焦虑障碍患病率为0.6％(95％CI0.4％～0.9％),惊恐障碍为0.2％ (95％CI0.1％～0.4％)；青壮年人群焦虑障碍患病率为1.3％ (95％CI0.3％ ～4.7％),中年人群为3.0％ (95％ CI l.2％ ～7.4％),老年人群为7.1％ (95％ CI5.4％ ～9.2％)；城市焦虑障碍患病率为2.8％ (95％CI l.1％～7.5％),农村地区为2.9％ (95％ CI l.5％～5.6％)；1982-1992年的研究焦虑障碍患病率合并为0.3％ (95％ CI0.1％～0.6％),1993-2000年为0.5％(95％CI0.2％～1.1％),2001年后为2.8％(95％ CI2.1％ ～3.8％)；应用国内诊断标准的焦虑障碍患病率为0.3％(95％CI0.1％ ～0.8％),国外/国际诊断标准为3.2％(95％CI2.3％～4.4％)；观察性流行病学研究报告规范评分结果为(14.36±3.17)分.结论 中国普通人群焦虑障碍总患病率较低,但研究报告总体水平有待进一步提高；中老年人群、2001年后的调研、应用《国际疾病分类标准》及《美国精神障碍诊断与统计手册》诊断系统的患病率相对较高.
目的 評價中國普通人群1982-2012年焦慮障礙患病率及其在性彆、年齡、城鄉、婚姻狀況、教育程度、調研年代、診斷標準等不同因素間的差彆.方法 檢索EMBASE、PubMed和中國期刊全文數據庫、萬方數字化期刊全文數據庫、中國科技期刊數據庫(維普)、中國生物醫學文獻數據庫等,併輔以文獻追溯方法,收集1982-2012年在國內外公開髮錶的所有關于中國人群焦慮障礙患病率的研究文獻,依照事先定義的納入及排除標準進行篩選,併根據觀察性研究的報告標準評價文獻質量,採用R-2.15.0軟件對資料間異質性檢驗、敏感性分析、閤併患病率及髮錶偏倚評估進行Meta分析.結果 共25項研究196 020人納入分析.焦慮障礙時點患病率為1.0％[95％可信區間(CI)0.7％～1.4％],12箇月患病率為4.5％(95％CI2.7％ ～7.5％),終生患病率為3.2％ (95％ CI 2.1％～4.7％).以時點患病率計,廣汎性焦慮障礙患病率為0.6％(95％CI0.4％～0.9％),驚恐障礙為0.2％ (95％CI0.1％～0.4％)；青壯年人群焦慮障礙患病率為1.3％ (95％CI0.3％ ～4.7％),中年人群為3.0％ (95％ CI l.2％ ～7.4％),老年人群為7.1％ (95％ CI5.4％ ～9.2％)；城市焦慮障礙患病率為2.8％ (95％CI l.1％～7.5％),農村地區為2.9％ (95％ CI l.5％～5.6％)；1982-1992年的研究焦慮障礙患病率閤併為0.3％ (95％ CI0.1％～0.6％),1993-2000年為0.5％(95％CI0.2％～1.1％),2001年後為2.8％(95％ CI2.1％ ～3.8％)；應用國內診斷標準的焦慮障礙患病率為0.3％(95％CI0.1％ ～0.8％),國外/國際診斷標準為3.2％(95％CI2.3％～4.4％)；觀察性流行病學研究報告規範評分結果為(14.36±3.17)分.結論 中國普通人群焦慮障礙總患病率較低,但研究報告總體水平有待進一步提高；中老年人群、2001年後的調研、應用《國際疾病分類標準》及《美國精神障礙診斷與統計手冊》診斷繫統的患病率相對較高.
목적 평개중국보통인군1982-2012년초필장애환병솔급기재성별、년령、성향、혼인상황、교육정도、조연년대、진단표준등불동인소간적차별.방법 검색EMBASE、PubMed화중국기간전문수거고、만방수자화기간전문수거고、중국과기기간수거고(유보)、중국생물의학문헌수거고등,병보이문헌추소방법,수집1982-2012년재국내외공개발표적소유관우중국인군초필장애환병솔적연구문헌,의조사선정의적납입급배제표준진행사선,병근거관찰성연구적보고표준평개문헌질량,채용R-2.15.0연건대자료간이질성검험、민감성분석、합병환병솔급발표편의평고진행Meta분석.결과 공25항연구196 020인납입분석.초필장애시점환병솔위1.0％[95％가신구간(CI)0.7％～1.4％],12개월환병솔위4.5％(95％CI2.7％ ～7.5％),종생환병솔위3.2％ (95％ CI 2.1％～4.7％).이시점환병솔계,엄범성초필장애환병솔위0.6％(95％CI0.4％～0.9％),량공장애위0.2％ (95％CI0.1％～0.4％)；청장년인군초필장애환병솔위1.3％ (95％CI0.3％ ～4.7％),중년인군위3.0％ (95％ CI l.2％ ～7.4％),노년인군위7.1％ (95％ CI5.4％ ～9.2％)；성시초필장애환병솔위2.8％ (95％CI l.1％～7.5％),농촌지구위2.9％ (95％ CI l.5％～5.6％)；1982-1992년적연구초필장애환병솔합병위0.3％ (95％ CI0.1％～0.6％),1993-2000년위0.5％(95％CI0.2％～1.1％),2001년후위2.8％(95％ CI2.1％ ～3.8％)；응용국내진단표준적초필장애환병솔위0.3％(95％CI0.1％ ～0.8％),국외/국제진단표준위3.2％(95％CI2.3％～4.4％)；관찰성류행병학연구보고규범평분결과위(14.36±3.17)분.결론 중국보통인군초필장애총환병솔교저,단연구보고총체수평유대진일보제고；중노년인군、2001년후적조연、응용《국제질병분류표준》급《미국정신장애진단여통계수책》진단계통적환병솔상대교고.
Objective To evaluate the prevalence of anxiety disorder among China mainland residents in studies published from 1982 to 2012 through meta-analysis.Methods According to pre-defined selection criteria and exclusion criteria,epidemiological studies published during 1982 to 2012,on anxiety disorders among mainland general population in China were identified through searching Chinese Biological Medical Literature Database,Chongqing VIP database for Chinese Technical Periodicals,Wanfang Database,Chinese National Knowledge Infrastructure,EMBASE and PubMed.Hand searches of cross references were also conducted for further references.The quality of included studies were evaluated by Strengthening the Reporting of Observational Studies in Epidemiology (STROBE).R-2.15.0 software was employed for statistical analysis.Results Twenty-five studies were included (a total of 196 020 people).The overall point prevalence of anxiety disorder was 1.0％ (95％ CI 0.7％-1.4％),twelve-month prevalence was 4.5％ (95％ CI 2.7％-7.5％),and lifetime prevalence was 3.2％ (95％ CI 2.1％-4.7％).The point prevalence of generalized anxiety disorder and panic disorder were 0.6％ (95％ CI 0.4％-0.9％) and 0.2％ (95％ CI0.1％-0.4％) respectively.The pooled prevalence rates were 1.3％ (95％ CI 0.3％-4.7％) for the young and 3.0％ (95％ CI 1.2％-7.4％) for the middle-aged and 7.1％ (95％ CI 5.4％-9.2％) for older adults.The rates for urban and rural were 2.8％ (95％ CI 1.1％-7.5％) and 2.9％ (95 ％ CI 1.5％-5.6％).The prevalence during 1982 to 1992 survey was 0.3 ％ (95 ％ CI 0.1％-0.6％),during 1993 to 2000 was 0.5％ (95％ CI 0.2％-1.1％) and after 2001 was 2.8％ (95％ CI 2.1％-3.8％).The prevalence according to different diagnostic criteria were 0.3％ (95％ CI 0.1％-0.8％) for CCMD and 3.2％ (95％ CI 2.3％-4.4％) for ICD or DSM.Included studies were assessed by STROBE criteria,the average score was 14.36 (SD =3.17).Conclusions Compared with other countries,the overall prevalence of anxiety disorder is lower in China.Middle aged and elderly may be risk factors.The prevalence in studies conducted after 2001 and with the criteria of ICD or DSM is higher.The quality of reporting needs further improvement.
