CAJ | 학술논문

目的分析精神分裂症断裂基因1(DISC1)多态性rs821597与健康志愿者脑白质完整性的相关性.方法对60名健康志愿者根据基因DISC1多态性rs821597进行分型,分为危险等位基因携带者组(41名)和非危险等位基因携带者组(19名),并对所有受试者脑部进行弥散张量磁共振成像,以DTI-studio软件和统计参数图(SPM)软件对所得图像进行预处理,得到的各向异性分数(FA)图像在SPM软件中进行两样本t检验,获得两组FA差异统计参数图.结果在P＜0.05(FDR校正后)水平下,危险等位基因携带者组右侧尾状核区[蒙特利尔神经科学研究所(MNI)坐标:14,0,16;体素集=138体素]、左侧尾状核区(MNI:-14,0,16;体素集=23体素)白质FA值较非危险等位基因携带者组低.未发现危险等位基因携带者组有脑区FA值较非危险等位基因携带者组高.结论 DISC1多态性rs821597可能与人类脑白质完整性相关.
목적 분석정신분렬증단렬기인1(DISC1)다태성rs821597여건강지원자뇌백질완정성적상관성.방법 대60명건강지원자근거기인DISC1다태성rs821597진행분형,분위위험등위기인휴대자조(41명)화비위험등위기인휴대자조(19명),병대소유수시자뇌부진행미산장량자공진성상,이DTI-studio연건화통계삼수도(SPM)연건대소득도상진행예처리,득도적각향이성분수(FA)도상재SPM연건중진행량양본t검험,획득량조FA차이통계삼수도.결과 재P＜0.05(FDR교정후)수평하,위험등위기인휴대자조우측미상핵구[몽특리이신경과학연구소(MNI)좌표:14,0,16;체소집=138체소]、좌측미상핵구(MNI:-14,0,16;체소집=23체소)백질FA치교비위험등위기인휴대자조저.미발현위험등위기인휴대자조유뇌구FA치교비위험등위기인휴대자조고.결론 DISC1다태성rs821597가능여인류뇌백질완정성상관.
Objective To explore the association of a single nucleotide polymorphism (SNP) rs821597 in gene disrupted-in-schizophrenia-1 (DISC1) with white matter integrity in healthy people.Methods Sixty healthy persons were genotyped at the SNP rs821597 in DISC1 and were divided into two groups (risk allele carriers and non-risk allele carriers).Diffusion tensor magnetic resonance images of the whole brains were acquired with a single-shot echo planar imaging (EPI) sequence aligned to the straight axial plane.After preprocessed with DTI-studio and SPM5 software,the fractional anisotropy (FA) images of the two groups underwent two-sample t-test with voxel-based analysis in SPM5 software.Results Risk allele carriers showed reduced white matter FA in the right caudate nucleus (MNI:14,0,16 ; cluster =138 voxels) and left caudate nucleus(MNI:-14,0,16; cluster =23 voxels)compared with non-risk allele carriers (P ＜0.05,FDR multiple comparisons).Conclusion The SNP rs821597 in gene DISC1 may be associated with white matter integrity in healthy people.