CAJ | 학술논문

目的运用fMRI方法探讨精神分裂症患者的一级亲属在静息状态下的脑功能特点.方法招募精神分裂症患者的未患病的生物学父亲或母亲55名(父母组),以年龄、性别及教育程度与之基本匹配的健康人29名为对照(对照组),由经验丰富的精神科医生对被试者进行非结构性访谈.被试者进行静息状态下全脑fMRI,采用低频振幅作为测量指标,比较父母组与对照组之间的静息脑功能的差异.结果与对照组相比,父母组低频振幅减弱的脑区主要位于右侧的颞中回、中扣带、额上回/额中回、额下回三角部以及双侧的角回;父母组低频振幅增强的脑区主要位于双侧的舌回[左侧:蒙特利尔神经科学研究所坐标(x、y、z)为-12、-81、3,t=4.08;右侧:蒙特利尔神经科学研究所坐标(x、y、z)为9、-57、3,t=3.88;均P＜0.01,已校正].结论精神分裂症患者一级亲属在静息状态下存在多个脑区功能异常,可能与精神分裂症的遗传易患性有关.
목적 운용fMRI방법탐토정신분렬증환자적일급친속재정식상태하적뇌공능특점.방법 초모정신분렬증환자적미환병적생물학부친혹모친55명(부모조),이년령、성별급교육정도여지기본필배적건강인29명위대조(대조조),유경험봉부적정신과의생대피시자진행비결구성방담.피시자진행정식상태하전뇌fMRI,채용저빈진폭작위측량지표,비교부모조여대조조지간적정식뇌공능적차이.결과 여대조조상비,부모조저빈진폭감약적뇌구주요위우우측적섭중회、중구대、액상회/액중회、액하회삼각부이급쌍측적각회;부모조저빈진폭증강적뇌구주요위우쌍측적설회[좌측:몽특리이신경과학연구소좌표(x、y、z)위-12、-81、3,t=4.08;우측:몽특리이신경과학연구소좌표(x、y、z)위9、-57、3,t=3.88;균P＜0.01,이교정].결론정신분렬증환자일급친속재정식상태하존재다개뇌구공능이상,가능여정신분렬증적유전역환성유관.
Objective To explore the differences of brain function between the first-degree relatives of schizophrenia patients and normal controls with resting-state functional magnetic imaging (fMRI).Methods Fifty-five unaffected biological fathers or mothers of schizophrenia patients and twenty-nine ageand gender-matched controls were enrolled and screened by experienced psychiatrists with a unstructured interview in this study.Then a resting-state fMRI scan was conducted for each participant.Amplitude of lowfrequency fluctuations (ALFF) approach was used to explore the differences of resting-state brain function between parents and controls.Results Compared with the controls,unaffected parents showed significantly decreased ALFF in the right middle temple cortex,middle cingulate cortex,superior frontal cortex/middle frontal cortex,triangular part of inferior frontal cortex and bilateral angular cortices.Parents also showed significantly increased ALFF in the bilateral lingual cortices (left:Montreal Neurological Institute(x,y,z):-12,-81,3,t =4.08,right:Montreal Neurological Institute (x,y,z):9,-57,3,t =3.88,P ＜ 0.01,corrected).Conclusions The results indicate there are dysfunctions of brain areas in the first-degree relatives of schizophrenia patients during resting state,which may reflect a genetic risk for schizophrenia.