中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2014年
3期
142-145
,共4页
赵可%王强%邓伟%李名立%韩媛媛%林鄞%丁蕾%李寅飞%李涛
趙可%王彊%鄧偉%李名立%韓媛媛%林鄞%丁蕾%李寅飛%李濤
조가%왕강%산위%리명립%한원원%림은%정뢰%리인비%리도
精神分裂症%磁共振成像,弥散%脑白质
精神分裂癥%磁共振成像,瀰散%腦白質
정신분렬증%자공진성상,미산%뇌백질
Schizophrenia%Diffusion magnetic resonance imaging%White matter
目的 研究精神分裂症首次发病患者前联合白质结构的完整性,探索其与精神分裂症症状间的关系.方法 对24例精神分裂症首次发病患者(患者组)、29名健康者(对照组)行弥散张量成像(diffusion tensor imaging,DTI)扫描,使用纤维束追踪的方法重建前联合纤维,并研究前联合白质结构连接异常与精神病性症状间的关系.结果 患者组前联合平均部分各向异性分数(fractionalanisotropy,FA)值(0.482±0.068)较对照组(0.537±0.053)明显下降(F=10.418,P=0.002).患者组入组时PANSS总分为(96.3±17.7)分,其中阴性症状分量表分为(19.2±7.8)分,阳性症状分量表分为(27.0±6.5)分.患者组前联合FA值与入组时阳性因子分呈负相关(r=-0.533,P=0.013),但与PANSS总分和阴性因子分间无相关性(均P＞0.05).结论 前联合白质纤维微结构的受损可能与精神分裂症患者幻觉、妄想等阳性症状的产生机制相关.
目的 研究精神分裂癥首次髮病患者前聯閤白質結構的完整性,探索其與精神分裂癥癥狀間的關繫.方法 對24例精神分裂癥首次髮病患者(患者組)、29名健康者(對照組)行瀰散張量成像(diffusion tensor imaging,DTI)掃描,使用纖維束追蹤的方法重建前聯閤纖維,併研究前聯閤白質結構連接異常與精神病性癥狀間的關繫.結果 患者組前聯閤平均部分各嚮異性分數(fractionalanisotropy,FA)值(0.482±0.068)較對照組(0.537±0.053)明顯下降(F=10.418,P=0.002).患者組入組時PANSS總分為(96.3±17.7)分,其中陰性癥狀分量錶分為(19.2±7.8)分,暘性癥狀分量錶分為(27.0±6.5)分.患者組前聯閤FA值與入組時暘性因子分呈負相關(r=-0.533,P=0.013),但與PANSS總分和陰性因子分間無相關性(均P＞0.05).結論 前聯閤白質纖維微結構的受損可能與精神分裂癥患者幻覺、妄想等暘性癥狀的產生機製相關.
목적 연구정신분렬증수차발병환자전연합백질결구적완정성,탐색기여정신분렬증증상간적관계.방법 대24례정신분렬증수차발병환자(환자조)、29명건강자(대조조)행미산장량성상(diffusion tensor imaging,DTI)소묘,사용섬유속추종적방법중건전연합섬유,병연구전연합백질결구련접이상여정신병성증상간적관계.결과 환자조전연합평균부분각향이성분수(fractionalanisotropy,FA)치(0.482±0.068)교대조조(0.537±0.053)명현하강(F=10.418,P=0.002).환자조입조시PANSS총분위(96.3±17.7)분,기중음성증상분량표분위(19.2±7.8)분,양성증상분량표분위(27.0±6.5)분.환자조전연합FA치여입조시양성인자분정부상관(r=-0.533,P=0.013),단여PANSS총분화음성인자분간무상관성(균P＞0.05).결론 전연합백질섬유미결구적수손가능여정신분렬증환자환각、망상등양성증상적산생궤제상관.
Objective To investigate the white matter integrity of anterior commissure (AC),and to explore the relationship between AC connectivity and psychotic symptoms in first-episode schizophrenia.Methods Diffusion tensor imaging,scans were c onducted in 24 patients with first-episode schizophrenia and 29 healthy controls.Fiber tracking was used to reconstruct the white matter fiber connectivity of AC to examine white matter integrity.The relationship between AC integrity and psychotic symptoms was analyzed.Results Significant reduction in mean fractional anisotropy (FA) was found in patients (0.482 ± 0.068) compared with healthy controls(0.537 ± 0.053,F =10.418,P =0.002).The PANSS total score of patient was (96.3 ± 17.7),with positive symptom score of (27.0 ±6.5) and negative symptom score of (19.2 ± 7.8).In addition,mean FA value of AC tracts in patients was negatively correlated with PANSS positive symptom score (r =-0.533,P =0.013),but no significant correlation was found between FA value and PANSS total scores or negative symptom score (P ＞ 0.05).Conclusion The deficit of AC microstructure integrity may be related to the mechanism of positive symptom in schizophrenia.
