中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2014年
3期
158-163
,共6页
刘晓敏%张小芊%徐波%申晨煜%史璐洁%马湘雲%任夏瑾%孙高翔%冯坤
劉曉敏%張小芊%徐波%申晨煜%史璐潔%馬湘雲%任夏瑾%孫高翔%馮坤
류효민%장소천%서파%신신욱%사로길%마상운%임하근%손고상%풍곤
谱学,近红外线%前额叶皮质%言语流畅任务%情绪%抑郁症%焦虑%强迫观念行为
譜學,近紅外線%前額葉皮質%言語流暢任務%情緒%抑鬱癥%焦慮%彊迫觀唸行為
보학,근홍외선%전액협피질%언어류창임무%정서%억욱증%초필%강박관념행위
Spectroscopy,near-infrared%Prefrontal cortex%Verbal fluency task%Emotion%Depressive disorder%Anxiety%Obsession behavior
目的 应用近红外光谱成像技术(functional near-infrared spectroscopy,fNIRS)研究综合医院精神科有焦虑和强迫症状的抑郁症患者前额叶功能激活的特点.方法 采用fNIRS测量比较30例抑郁症患者(患者组)和30名对照(对照组)在执行语义言语流畅任务(verbal fluency task,VFT)时前额叶血红蛋白浓度变化,利用HAMD、HAMA、耶鲁-布朗强迫量表(Y-BOCS)、症状自评量表(SCl-90)进行心理评估,并采用Spearman相关进行相关性分析.结果 (1)与对照组比较,患者组前额叶外侧通道和中间下侧通道含氧血红蛋白任务期升高幅度的差异有统计学意义(均P ＜0.05);(2)患者组焦虑症状与右外侧前额叶激活程度相关(r=0.370、0.380,均P＜0.05),抑郁症状与左右外侧前额叶及中间背侧前额叶激活程度相关(r =0.391、0.375、0.403、0.492、0.396、0.362、0.384,均P＜0.05),强迫症状与前额叶激活程度无统计学相关性.结论 具有焦虑和强迫症状的抑郁症患者存在前额叶功能激活下降,且焦虑症状和抑郁症状可能分别与右外侧前额叶、外侧前额叶及中间背侧前额叶激活程度相关.
目的 應用近紅外光譜成像技術(functional near-infrared spectroscopy,fNIRS)研究綜閤醫院精神科有焦慮和彊迫癥狀的抑鬱癥患者前額葉功能激活的特點.方法 採用fNIRS測量比較30例抑鬱癥患者(患者組)和30名對照(對照組)在執行語義言語流暢任務(verbal fluency task,VFT)時前額葉血紅蛋白濃度變化,利用HAMD、HAMA、耶魯-佈朗彊迫量錶(Y-BOCS)、癥狀自評量錶(SCl-90)進行心理評估,併採用Spearman相關進行相關性分析.結果 (1)與對照組比較,患者組前額葉外側通道和中間下側通道含氧血紅蛋白任務期升高幅度的差異有統計學意義(均P ＜0.05);(2)患者組焦慮癥狀與右外側前額葉激活程度相關(r=0.370、0.380,均P＜0.05),抑鬱癥狀與左右外側前額葉及中間揹側前額葉激活程度相關(r =0.391、0.375、0.403、0.492、0.396、0.362、0.384,均P＜0.05),彊迫癥狀與前額葉激活程度無統計學相關性.結論 具有焦慮和彊迫癥狀的抑鬱癥患者存在前額葉功能激活下降,且焦慮癥狀和抑鬱癥狀可能分彆與右外側前額葉、外側前額葉及中間揹側前額葉激活程度相關.
목적 응용근홍외광보성상기술(functional near-infrared spectroscopy,fNIRS)연구종합의원정신과유초필화강박증상적억욱증환자전액협공능격활적특점.방법 채용fNIRS측량비교30례억욱증환자(환자조)화30명대조(대조조)재집행어의언어류창임무(verbal fluency task,VFT)시전액협혈홍단백농도변화,이용HAMD、HAMA、야로-포랑강박량표(Y-BOCS)、증상자평량표(SCl-90)진행심리평고,병채용Spearman상관진행상관성분석.결과 (1)여대조조비교,환자조전액협외측통도화중간하측통도함양혈홍단백임무기승고폭도적차이유통계학의의(균P ＜0.05);(2)환자조초필증상여우외측전액협격활정도상관(r=0.370、0.380,균P＜0.05),억욱증상여좌우외측전액협급중간배측전액협격활정도상관(r =0.391、0.375、0.403、0.492、0.396、0.362、0.384,균P＜0.05),강박증상여전액협격활정도무통계학상관성.결론 구유초필화강박증상적억욱증환자존재전액협공능격활하강,차초필증상화억욱증상가능분별여우외측전액협、외측전액협급중간배측전액협격활정도상관.
Objective Exploring the characteristics of prefrontal cortex activation in patients of major depressive disorder (MDD) combined with anxiety and obsession through functional near-infrared spectroscopy (fNIRS).Methods Prefrontal cortex hemoglobin concentration exchange of 30 MDD patients combined with anxiety and obsession was detected by fNIRS under voice fluency task (VFT),then psychological assessment was made using Hanmilton Depression Scale (HAMD),Hamilton Anxiety Scale (HAMA) and Symptom Checklist 90 (SCL-90).The exchange and assessment scores were compared.Results (1) Compared with control group,the decreased Oxy-Hb exchange was confirmed in lateral and lower prefrontal cortex in MDD patients (P ＜ 0.05) ;(2) Oxy-Hb exchange in right-lateral prefrontal cortex were associated with the severity of anxiety (r =0.370,0.380,both P ＜ 0.05),while that in bilateral prefrontal cortex and antero-medial prefrontal cortex were associated with severity of depression (r =0.391,0.375,0.403,0.492,0.396,0.362,0.384,all P ＜ 0.05).And no statistical correlation was observed between severity of obsession and prefrontal cortex.Conclusion It indicated hypoactivation state of prefrontal cortex was in MDD patients,while the severity of anxiety and depression may be associated with right-lateral prefrontal cortex,bilateral and antero-medial prefrontal cortex.
