CAJ | 학술논문

目的构建带血管蒂的下颌骨以修复下颌骨缺损.方法将肋骨骨松质碎块填入预制的下颌骨外形钛网支架中,植入5只实验犬背阔肌内并使胸背动静脉血管穿过钛网支架.术后3个月后取出标本,通过大体标本、组织学及免疫组化染色观察骨组织形成及血管化情况.结果在实验犬体内再造出了以胸背动静脉为蒂的骨组织,并具有下颌骨的解剖外形；组织学及免疫组化染色证实新骨形成及血管化较好.结论应用自体骨松质异位预构建血管化下颌骨具有可行性,为下颌骨缺损修复提供一种新思路和方法.
목적 구건대혈관체적하합골이수복하합골결손.방법 장륵골골송질쇄괴전입예제적하합골외형태망지가중,식입5지실험견배활기내병사흉배동정맥혈관천과태망지가.술후3개월후취출표본,통과대체표본、조직학급면역조화염색관찰골조직형성급혈관화정황.결과 재실험견체내재조출료이흉배동정맥위체적골조직,병구유하합골적해부외형；조직학급면역조화염색증실신골형성급혈관화교호.결론 응용자체골송질이위예구건혈관화하합골구유가행성,위하합골결손수복제공일충신사로화방법.
Objective To explore a method for ectopic prefabrication of mandible with vascular pedicle.Methods Canccllous bone blocks harvested from the dog ribs were packaged with mandible-shaped titanium mesh scaffold and implanted into latissimus dorsi of dog with thoracodorsal artery and vein through the scaffold. After 12 weeks, bone formation and vascularization were evaluated by gross inspection,histological examination and immunohistochemistry.Results Vascularized mandible with thoracodorsal artery and vein were formed and histological staining and immunohistochemisty confirmed new bone formation and vascularization. Conclusions There is feasibility for ectopic prefabrication of vascularized mandible graft using cancellous ribs,which provides a new method for mandibular defect reconstruction.Experimental study on ectopic prefabrication of vascularized mandible graft with autogenous ribs.