中华口腔医学杂志
中華口腔醫學雜誌
중화구강의학잡지
Chinese Journal of Stomatology
2012年
12期
711-714
,共4页
孙健%余优成%骆一西%田臻
孫健%餘優成%駱一西%田臻
손건%여우성%락일서%전진
癌,腺样囊性%基质金属蛋白酶9%上皮钙黏素%ErbB-3结合蛋白1
癌,腺樣囊性%基質金屬蛋白酶9%上皮鈣黏素%ErbB-3結閤蛋白1
암,선양낭성%기질금속단백매9%상피개점소%ErbB-3결합단백1
Carcinoma,adenoid cystic%Matrix metalloproteinase 9%Epithelial cadherin%ErbB-3 binding protein 1
目的 探讨ErbB-3结合蛋白1(ErbB-3 binding protein-1,EBP-1)、基质金属蛋白酶9(matrix metalloproteinase 9,MMP-9)和上皮钙黏素(E-cadherin,E-cad)在涎腺腺样囊性癌(adenoid cystic carcinoma,ACC)组织中的表达及相关意义.方法 采用免疫组织化学PV6000法检测EBP-1、MMP-9和E-cad在66例涎腺ACC及相应癌旁正常涎腺组织中的表达.结果 EBP-1的表达阳性率:癌旁正常涎腺组织中99％(65/66),显著高于涎腺ACC组织表达85％(56/66),P=0.040.EBP-1蛋白表达强度与肿瘤的组织学类型、侵袭转移类型及分期密切相关(P＜0.05),但与患者的年龄、性别无明显相关性(P＞0.05).其中,预后较差的病理分型和临床分期以及肿瘤转移的组织中EBP-1的表达较低.EBP-1与E-cad的表达呈正相关(r=0.834,P＜0.001)；与MMP-9的表达呈负相关(r=-0.321,P＜0.001).结论 EBP-1表达下调可作为涎腺ACC恶性程度的评价指标之一；EBP-1与E-cad或MMP-9的相关性对判断涎腺ACC肿瘤生物学行为具有一定意义.
目的 探討ErbB-3結閤蛋白1(ErbB-3 binding protein-1,EBP-1)、基質金屬蛋白酶9(matrix metalloproteinase 9,MMP-9)和上皮鈣黏素(E-cadherin,E-cad)在涎腺腺樣囊性癌(adenoid cystic carcinoma,ACC)組織中的錶達及相關意義.方法 採用免疫組織化學PV6000法檢測EBP-1、MMP-9和E-cad在66例涎腺ACC及相應癌徬正常涎腺組織中的錶達.結果 EBP-1的錶達暘性率:癌徬正常涎腺組織中99％(65/66),顯著高于涎腺ACC組織錶達85％(56/66),P=0.040.EBP-1蛋白錶達彊度與腫瘤的組織學類型、侵襲轉移類型及分期密切相關(P＜0.05),但與患者的年齡、性彆無明顯相關性(P＞0.05).其中,預後較差的病理分型和臨床分期以及腫瘤轉移的組織中EBP-1的錶達較低.EBP-1與E-cad的錶達呈正相關(r=0.834,P＜0.001)；與MMP-9的錶達呈負相關(r=-0.321,P＜0.001).結論 EBP-1錶達下調可作為涎腺ACC噁性程度的評價指標之一；EBP-1與E-cad或MMP-9的相關性對判斷涎腺ACC腫瘤生物學行為具有一定意義.
목적 탐토ErbB-3결합단백1(ErbB-3 binding protein-1,EBP-1)、기질금속단백매9(matrix metalloproteinase 9,MMP-9)화상피개점소(E-cadherin,E-cad)재연선선양낭성암(adenoid cystic carcinoma,ACC)조직중적표체급상관의의.방법 채용면역조직화학PV6000법검측EBP-1、MMP-9화E-cad재66례연선ACC급상응암방정상연선조직중적표체.결과 EBP-1적표체양성솔:암방정상연선조직중99％(65/66),현저고우연선ACC조직표체85％(56/66),P=0.040.EBP-1단백표체강도여종류적조직학류형、침습전이류형급분기밀절상관(P＜0.05),단여환자적년령、성별무명현상관성(P＞0.05).기중,예후교차적병리분형화림상분기이급종류전이적조직중EBP-1적표체교저.EBP-1여E-cad적표체정정상관(r=0.834,P＜0.001)；여MMP-9적표체정부상관(r=-0.321,P＜0.001).결론 EBP-1표체하조가작위연선ACC악성정도적평개지표지일；EBP-1여E-cad혹MMP-9적상관성대판단연선ACC종류생물학행위구유일정의의.
Objective To investigate the expression of ErbB-3 binding protein-1 (EBP-1),matrix metalloproteinase 9 (MMP-9) and E-cadherin (E-cad) in adenoid cystic carcinoma and their correlation.Methods Immunohistochemistry (PV6000 method) was used to detect EBP-1,MMP-9 and E-cad expression in 66 cases of adenoid cystic carcinoma tissues and matched para-cancerous normal tissues.In this study all cases were successfully followed up.Results The positive expression rate of EBP-1 in adenoid cystic carcinoma tissues was 85％.EBP-1 expression was significantly correlated to pathological pattern and clinical stage (P ＜ 0.05),but not to gender and age.In addition,there was a negative correlation between EBP-1 and E-cad expression,and positive correlation between EBP-1 and MMP-9.Conclusions EBP-1 and its correlation with MMP-9 and E-cad may be used as useful indicators for clinical assessment of tumor biological behavior and prognosis in patients with adenoid cystic carcinoma.
