CAJ | 학술논문

目的探讨HIV感染者中与人类疱疹病毒1、3、4、5、8型相关的口腔损害的发病情况及其与CD4的关系,以期初步明确HIV感染者中常见的口腔疱疹病毒损害的发病特征.方法对2007年12月至2011年12月昆明市第三人民医院感染—科992例未接受高效抗反转录病毒治疗的HIV感染者进行口腔检查,并收集患者CD4计数等资料,采用SPSS11.3软件建立数据库并进行相关指标的统计学分析.结果 992例患者中发生与疱疹病毒相关的口腔损害209例(21.1％),单纯疱疹、带状疱疹、毛状白斑、复发性阿弗他溃疡和卡波西肉瘤分别占10.8％(107/992)、0.7％ (7/992)、9.1％(90/992)、9.3％(92/992)和0.5％(5/992).单纯疱疹和毛状白斑与CD4计数有关(P＜0.05),而复发性阿弗他溃疡、口腔带状疱疹和卡波西肉瘤与CD4计数无关.结论云南地区HIV感染者中人类疱疹病毒感染相关口腔损害以单纯疱疹病毒感染、复发性阿弗他溃疡和毛状白斑多见.
목적 탐토HIV감염자중여인류포진병독1、3、4、5、8형상관적구강손해적발병정황급기여CD4적관계,이기초보명학HIV감염자중상견적구강포진병독손해적발병특정.방법 대2007년12월지2011년12월곤명시제삼인민의원감염—과992례미접수고효항반전록병독치료적HIV감염자진행구강검사,병수집환자CD4계수등자료,채용SPSS11.3연건건립수거고병진행상관지표적통계학분석.결과 992례환자중발생여포진병독상관적구강손해209례(21.1％),단순포진、대상포진、모상백반、복발성아불타궤양화잡파서육류분별점10.8％(107/992)、0.7％ (7/992)、9.1％(90/992)、9.3％(92/992)화0.5％(5/992).단순포진화모상백반여CD4계수유관(P＜0.05),이복발성아불타궤양、구강대상포진화잡파서육류여CD4계수무관.결론 운남지구HIV감염자중인류포진병독감염상관구강손해이단순포진병독감염、복발성아불타궤양화모상백반다견.
Objective To investigate the morbidity of oral lesions related to human herpesvirus among a group of HIV-infected patients and its relationship with CD4.Methods A cross-sectional study was conducted in the 992 HIV-infected patients who did not receive highly active anti-retroviral therapy (HAART) in Yunnan area.Oral examination were performed by 4 dentists.Counts of CD4 + and other data were collected and statistically analyzed.Results Of the 992 cases,209 (21.1％) cases with oral lesions related to human herpesvirus were found.The virus-related diseases included herpes simplex virus (HSV) infection (10.8％,107/992),herps zoster (0.7％,7/992),oral hairy leukoplakia (OHL) (9.1％,90/992),recurrent aphthous ulcer (RAU) (9.3 ％,92/992) and Kaposi sarcoma (KS) (0.5 ％,5/992).There was a correlation between CD4 + counts and incidence of HSV infection,OHL and RAU.Oral hepes zoster had no correlation with CD4 counts.Conclusions Oral lesions associated with human herpesvirus were very common in Yunnan HIV-infected people.Among them,incidence of HSV infection,RAU and OHL was most frequently seen.