CAJ | 학술논문

目的通过测定镍铬合金烤瓷修复体拆除前后患者尿和血清中的镍铬含量,对镍铬合金的临床应用安全性进行科学评估.方法选择因怀疑镍铬合金烤瓷修复体的镍、铬元素对全身有影响,主动要求拆除修复体的患者86例,于修复体拆前、拆后1个月采用石墨炉原子吸收光谱法检测患者尿镍、铬含量(86例)和血清镍、铬含量(69例).结果镍铬烤瓷修复体拆除前后86例患者尿镍含量分别为(3.52±3.05)和(3.31 ±3.28) μg/L,尿铬含量分别为(0.81±0.54)和(1.34±1.15) μg/L;修复体拆除前后69例患者血清镍含量分别为(2.04±1.06)和(2.67±2.32) μg/L,血清铬含量分别为(1.07±0.88)和(1.02±0.86) μg/L;拆除前后差异均无统计学意义(P＞0.05).结论本项研究条件下镍铬合会烤瓷修复体释放的镍、铬离子量微小,不足以对人体尿液及血液中的镍、铬含量造成影响.
목적 통과측정얼락합금고자수복체탁제전후환자뇨화혈청중적얼락함량,대얼락합금적림상응용안전성진행과학평고.방법 선택인부의얼락합금고자수복체적얼、락원소대전신유영향,주동요구탁제수복체적환자86례,우수복체탁전、탁후1개월채용석묵로원자흡수광보법검측환자뇨얼、락함량(86례)화혈청얼、락함량(69례).결과 얼락고자수복체탁제전후86례환자뇨얼함량분별위(3.52±3.05)화(3.31 ±3.28) μg/L,뇨락함량분별위(0.81±0.54)화(1.34±1.15) μg/L;수복체탁제전후69례환자혈청얼함량분별위(2.04±1.06)화(2.67±2.32) μg/L,혈청락함량분별위(1.07±0.88)화(1.02±0.86) μg/L;탁제전후차이균무통계학의의(P＞0.05).결론 본항연구조건하얼락합회고자수복체석방적얼、락리자량미소,불족이대인체뇨액급혈액중적얼、락함량조성영향.
Objective To investigate the clinical application safety of nickel-chromium alloy in porcelain-fused-to-metal (PFM) restoration by assessment of nickel and chromium levels in human urine and serum before and after the removal of the restoration.Methods Eighty-six patients were recruited in the study.They were those who suspected that nickel-chromium alloy PFM might affect their health and therefore came to hospital to ask for removal of prosthesis.The nickel and chromium levels in urine of these patients were examined before and after removal the nickel-chromium alloy PFM restoration.At the same time,sixty nine of these 86 patients also underwent blood test to exam the serum nickel and chromium levels before and after the removal of the nickel-chromium alloy PFM restorations.In addition,the urinary nickel and chromium levels in these patients were also analyzed according to their age,gender,the number and duration of PFM restorations,and the extent of metal exposure in their restoration.Results The urinary nickel levels before and after removal of the nickel-chromium alloy PFM restoration in 86 patients were (3.52 ±3.05) μg/L and (3.31 ± 3.28) μg/L respectively.The urinary chromium levels before and after removal of the nickel-chromium alloy PFM restoration were (0.81 ± 0.54) μg/L and (1.34 ± 1.15) μg/Lrespectively.The serum nickel levels before and after removal of the nickel-chromium alloy PFM restoration in 69 patients were (2.04 ± 1.06) μg/L and (2.67 ± 2.32) μg/L respectively.The serum chromium levels before and after removal of the nickel-c hromium alloy PFM restoration were (1.07 ± 0.88) μg/L and (1.02 ± 0.86) μg/L respectively.There were no statistical difference between the results of the urinary and serum nickel and chromfium levels in patients before and after removal of the nickel-chromium alloy PFM restoration(P ＞ 0.05).Conclusions The amount of nickel and chromium released from nickel-chromium alloy PFM restoration is negligible,which would not affect the urine and serum levels of nickel and chromium in human.