中华口腔医学杂志
中華口腔醫學雜誌
중화구강의학잡지
Chinese Journal of Stomatology
2013年
3期
144-149
,共6页
廖雁婷%和璐%孟焕新%李蓬%沙月琴%王兴宇
廖雁婷%和璐%孟煥新%李蓬%沙月琴%王興宇
료안정%화로%맹환신%리봉%사월금%왕흥우
糖尿病,2型%牙周炎%唾液%牙周致病菌
糖尿病,2型%牙週炎%唾液%牙週緻病菌
당뇨병,2형%아주염%타액%아주치병균
Diabetes mellitus,type 2%Periodontitis%Sliva%Periodontal pathogen
目的 调查2型糖尿病患者群唾液中牙周致病菌的感染情况,初探血糖异常对口腔内牙周致病菌定植生长的影响.方法 筛选北京石景山社区的高血压人群,留取其中的45名非糖尿病者(非DM组)、80例血糖控制稳定(DM-好组)和100例血糖控制差的2型糖尿病患者(DM-差组)的静息全唾液,提取唾液中细菌基因组DNA,应用以16SrRNA为基础的PCR技术检测牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)、福赛坦菌(Tannerella forsythia,Tf)和齿垢密螺旋体(Treponema denticola,Td)3种牙周致病菌.应用SPSS15.0统计软件对不同血糖状况下唾液中3种牙周致病菌的检出差异进行比较,并在Logistic回归模型基础上分析与各种菌检出相关的变量因素.结果 DM-好组和DM-差组的Tf检出率[分别为81% (65/80)和80% (80/100)]均显著低于非DM组[91%(41/45)],差异均有统计学意义(P<0.05),DM-好组和DM-差组的Tf相对含量[分别为1.9(2.6)、2.1(5.3)]均显著低于非DM组[3.4(6.4)](P<0.05),且血糖控制越差,Tf的相对含量越低.Pg、Td在3组受检者中的检出率和相对含量差异均无统计学意义(P>0.05).调整了年龄、性别、缺牙数和其他牙周临床指标,DM-好组和DM-差组唾液中Tf定植的风险均较非DM组低,OR值分别为0.58和0.53.结论 Pg、Td在口腔内的定植可能未受血糖影响,血糖异常可能会影响口腔内Tf的定植.
目的 調查2型糖尿病患者群唾液中牙週緻病菌的感染情況,初探血糖異常對口腔內牙週緻病菌定植生長的影響.方法 篩選北京石景山社區的高血壓人群,留取其中的45名非糖尿病者(非DM組)、80例血糖控製穩定(DM-好組)和100例血糖控製差的2型糖尿病患者(DM-差組)的靜息全唾液,提取唾液中細菌基因組DNA,應用以16SrRNA為基礎的PCR技術檢測牙齦卟啉單胞菌(Porphyromonas gingivalis,Pg)、福賽坦菌(Tannerella forsythia,Tf)和齒垢密螺鏇體(Treponema denticola,Td)3種牙週緻病菌.應用SPSS15.0統計軟件對不同血糖狀況下唾液中3種牙週緻病菌的檢齣差異進行比較,併在Logistic迴歸模型基礎上分析與各種菌檢齣相關的變量因素.結果 DM-好組和DM-差組的Tf檢齣率[分彆為81% (65/80)和80% (80/100)]均顯著低于非DM組[91%(41/45)],差異均有統計學意義(P<0.05),DM-好組和DM-差組的Tf相對含量[分彆為1.9(2.6)、2.1(5.3)]均顯著低于非DM組[3.4(6.4)](P<0.05),且血糖控製越差,Tf的相對含量越低.Pg、Td在3組受檢者中的檢齣率和相對含量差異均無統計學意義(P>0.05).調整瞭年齡、性彆、缺牙數和其他牙週臨床指標,DM-好組和DM-差組唾液中Tf定植的風險均較非DM組低,OR值分彆為0.58和0.53.結論 Pg、Td在口腔內的定植可能未受血糖影響,血糖異常可能會影響口腔內Tf的定植.
목적 조사2형당뇨병환자군타액중아주치병균적감염정황,초탐혈당이상대구강내아주치병균정식생장적영향.방법 사선북경석경산사구적고혈압인군,류취기중적45명비당뇨병자(비DM조)、80례혈당공제은정(DM-호조)화100례혈당공제차적2형당뇨병환자(DM-차조)적정식전타액,제취타액중세균기인조DNA,응용이16SrRNA위기출적PCR기술검측아간계람단포균(Porphyromonas gingivalis,Pg)、복새탄균(Tannerella forsythia,Tf)화치구밀라선체(Treponema denticola,Td)3충아주치병균.응용SPSS15.0통계연건대불동혈당상황하타액중3충아주치병균적검출차이진행비교,병재Logistic회귀모형기출상분석여각충균검출상관적변량인소.결과 DM-호조화DM-차조적Tf검출솔[분별위81% (65/80)화80% (80/100)]균현저저우비DM조[91%(41/45)],차이균유통계학의의(P<0.05),DM-호조화DM-차조적Tf상대함량[분별위1.9(2.6)、2.1(5.3)]균현저저우비DM조[3.4(6.4)](P<0.05),차혈당공제월차,Tf적상대함량월저.Pg、Td재3조수검자중적검출솔화상대함량차이균무통계학의의(P>0.05).조정료년령、성별、결아수화기타아주림상지표,DM-호조화DM-차조타액중Tf정식적풍험균교비DM조저,OR치분별위0.58화0.53.결론 Pg、Td재구강내적정식가능미수혈당영향,혈당이상가능회영향구강내Tf적정식.
Objective To investigate the prevalence of periodontal pathogens from saliva of patients with type 2 diabetes mellitus (T2DM),and to characterize the association between the glucose status and periodontal pathogens in oral cavity.Methods All the subjects were hypertension patients under regular care at Beijing hypertension prevention and management institute.Whole unstimulated saliva samples were collected from 45 non-diabetic subjects (non-DM group),80 well-controlled diabetic patients (DM-well group) and 100 poor-controlled diabetic patients (DM-poor group).DNA was extracted from the salivary deposition,Porphyromonas gingivalis (Pg),Tannerella forsythia (Tf) and Treponema denticola (Td) were detected by polymerase chain reaction (PCR) method based on 16SrRNA.Prevalence and quantity of the pathogens under different glucose states were compared and logistic regression model was set to analyze the factors related to each bacterium.Results The prevalence of Tf in DM-well group and DM-poor group was significantly lower than that of non-DM group [81% (65/80),80% (80/100) vs 91% (41/45),P =0.048],meanwhile the quantity of Tf was also lower than that of non-DM group[1.9 (2.6),2.1(5.3) vs 3.4 (6.4)] (P > 0.05).With the worsening of glucose control,the quantity of Tf was declining (P =0.032).However,the prevalence and the quantity of Pg,Td in 3 groups had no statistical differences(P >0.05).After adjusting age,gender,number of missing teeth and other periodontal parameters,OR of having Tf in saliva from DM-well group and DM-poor group was 0.58 and 0.53,respectively.Conclusions Abnormal blood glucose state may affect the colonization of Tf in oral cavity.