中华口腔医学杂志
中華口腔醫學雜誌
중화구강의학잡지
Chinese Journal of Stomatology
2014年
8期
454-458
,共5页
温龑%李承文%裴峻浩翔%白劲松%杨向红%段开文
溫龑%李承文%裴峻浩翔%白勁鬆%楊嚮紅%段開文
온엄%리승문%배준호상%백경송%양향홍%단개문
获得性免疫缺陷综合征%人免疫缺陷病毒%念珠菌病,口腔%CD4淋巴细胞计数%高效抗反转录治疗
穫得性免疫缺陷綜閤徵%人免疫缺陷病毒%唸珠菌病,口腔%CD4淋巴細胞計數%高效抗反轉錄治療
획득성면역결함종합정%인면역결함병독%념주균병,구강%CD4림파세포계수%고효항반전록치료
Acquired immunodeficiency syndrome%Human immunodeficiency virus%Oral Candidosis%CD4 lymphocyte count%Highly active antiretroviral therapy
目的 探讨人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者及获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)患者中口腔念珠菌病(oral candidosis,OC)的患病情况及影响因素,以期为防治HIV/AIDS患者口腔真菌感染性疾病提供依据.方法 对2008年3月至2012年9月于昆明市第三人民医院感染一科就诊的1 566例(男性1 062例,女性504例,年龄0.2～ 84.0岁)HIV/AIDS患者进行口腔检查,HIV病毒载量(HIV-RNA)和外周血CD4计数采用流式细胞技术进行分析,高效抗反转录病毒药物(highly active antiretroviral therapy,HAART)使用情况和传播途径等信息通过问卷获得,采用SPSS17.0统计软件建立数据库,分析比较不同HIV-RNA和CD4计数水平及HAART对OC患病率的影响.结果 1 566例HIV/AIDS患者的OC患病率为31.0％(486/1 566),无性别差异,表现为红斑型、假膜型和口角炎型3种形式,患病率分别为13.9％(217/1 566)、17.0％(267/1 566)和4.9％(77/1 566),其中75例患者有两种以上表现形式,3型患者的平均CD4水平[中位数(四分位数间距)]分别为81.0(146.0)、74.0(152.0)和69.0(121.5)个/μl,差异无统计学意义(P＞0.05).未使用和使用HAART患者OC的患病率分别为36.3％(402/1 107)和18.3％(84/459),二者差异有统计学意义(P=0.000).OC与非OC患者CD4计数[分别为81.0(150.0)、179.0(231.3)个/μl]和HIV病毒载量水平差异均有统计学意义(Z=-10.261,P=0.000;Z=-4.762,P=0.000).结论 云南地区HIV/AIDS患者OC患病率很高,包括假膜型、红斑型和口角炎型,未检出增殖型;OC的患病率与患者免疫抑制程度和HIV病毒载量有关.
目的 探討人類免疫缺陷病毒(human immunodeficiency virus,HIV)感染者及穫得性免疫缺陷綜閤徵(acquired immunodeficiency syndrome,AIDS)患者中口腔唸珠菌病(oral candidosis,OC)的患病情況及影響因素,以期為防治HIV/AIDS患者口腔真菌感染性疾病提供依據.方法 對2008年3月至2012年9月于昆明市第三人民醫院感染一科就診的1 566例(男性1 062例,女性504例,年齡0.2～ 84.0歲)HIV/AIDS患者進行口腔檢查,HIV病毒載量(HIV-RNA)和外週血CD4計數採用流式細胞技術進行分析,高效抗反轉錄病毒藥物(highly active antiretroviral therapy,HAART)使用情況和傳播途徑等信息通過問捲穫得,採用SPSS17.0統計軟件建立數據庫,分析比較不同HIV-RNA和CD4計數水平及HAART對OC患病率的影響.結果 1 566例HIV/AIDS患者的OC患病率為31.0％(486/1 566),無性彆差異,錶現為紅斑型、假膜型和口角炎型3種形式,患病率分彆為13.9％(217/1 566)、17.0％(267/1 566)和4.9％(77/1 566),其中75例患者有兩種以上錶現形式,3型患者的平均CD4水平[中位數(四分位數間距)]分彆為81.0(146.0)、74.0(152.0)和69.0(121.5)箇/μl,差異無統計學意義(P＞0.05).未使用和使用HAART患者OC的患病率分彆為36.3％(402/1 107)和18.3％(84/459),二者差異有統計學意義(P=0.000).OC與非OC患者CD4計數[分彆為81.0(150.0)、179.0(231.3)箇/μl]和HIV病毒載量水平差異均有統計學意義(Z=-10.261,P=0.000;Z=-4.762,P=0.000).結論 雲南地區HIV/AIDS患者OC患病率很高,包括假膜型、紅斑型和口角炎型,未檢齣增殖型;OC的患病率與患者免疫抑製程度和HIV病毒載量有關.
목적 탐토인류면역결함병독(human immunodeficiency virus,HIV)감염자급획득성면역결함종합정(acquired immunodeficiency syndrome,AIDS)환자중구강념주균병(oral candidosis,OC)적환병정황급영향인소,이기위방치HIV/AIDS환자구강진균감염성질병제공의거.방법 대2008년3월지2012년9월우곤명시제삼인민의원감염일과취진적1 566례(남성1 062례,녀성504례,년령0.2～ 84.0세)HIV/AIDS환자진행구강검사,HIV병독재량(HIV-RNA)화외주혈CD4계수채용류식세포기술진행분석,고효항반전록병독약물(highly active antiretroviral therapy,HAART)사용정황화전파도경등신식통과문권획득,채용SPSS17.0통계연건건립수거고,분석비교불동HIV-RNA화CD4계수수평급HAART대OC환병솔적영향.결과 1 566례HIV/AIDS환자적OC환병솔위31.0％(486/1 566),무성별차이,표현위홍반형、가막형화구각염형3충형식,환병솔분별위13.9％(217/1 566)、17.0％(267/1 566)화4.9％(77/1 566),기중75례환자유량충이상표현형식,3형환자적평균CD4수평[중위수(사분위수간거)]분별위81.0(146.0)、74.0(152.0)화69.0(121.5)개/μl,차이무통계학의의(P＞0.05).미사용화사용HAART환자OC적환병솔분별위36.3％(402/1 107)화18.3％(84/459),이자차이유통계학의의(P=0.000).OC여비OC환자CD4계수[분별위81.0(150.0)、179.0(231.3)개/μl]화HIV병독재량수평차이균유통계학의의(Z=-10.261,P=0.000;Z=-4.762,P=0.000).결론 운남지구HIV/AIDS환자OC환병솔흔고,포괄가막형、홍반형화구각염형,미검출증식형;OC적환병솔여환자면역억제정도화HIV병독재량유관.
Objective To assess the incidence of oral candidiasis and its influencing factors in patients with human immunodeficiency virus infection/acquired immunodeficiency syndrome(HIV/AIDS).Methods An oral examination was conducted in the 1 566 HIV/AIDS patients in the Third Hospital of Kunming from March 2008 to September 2012 (M/F:1 062/504,age range:0.2 to 84.0 years old).The HIV viral load(HIV-RNA) and peripheral blood CD4 count were respectively analyzed by Bayer Q340 fluorescence signal surveying instrument(bDNA method) and flow cytometry analysis.The information on usage of highly active anti-retroviral(HAART) drugs and transmission of HIV were obtained through questionnaires.The incidence of oral candidiasis in patients with different HIV-RNA levels and CD4 count and the use of HAART was analyzed and compared.Results The total incidence of oral candidosis was 31.0％(486/1 566) and there was no difference in sex.The oral lesions were presented by three types,psudomembranous candidosis(PC),erythematous candidosis(EC) and angular cheilitis(AC),and the morbidity was 13.9％(217/1 566),17.0％(267/1 566) and 4.9％(77/1 566),respectively.The average level of CD4 count in psudomembranous candidosis,erythematous candidosis and angular cheilitis[81.0 (146.0),74.0 (152.0) and 69.0 (121.5) cell/μl] showed no significant difference(P ＞ 0.05).The incidence of oral candidiasis in non-HAART and HAART subjects were 36.3％(402/1 107) and 18.3％(84/459),respectively(P=0.000).The CD4 count and absolute counts of HIV viral load in oral candidiasis patients and non-oral candidiasis patients had significant difference(Z=-10.261,P=0.000 and Z=-4.762,P=0.000).Conclusions The morbidity of oral candidiasis in HIV/AIDS patients in Yunnan Province was high,including PC,EC and AC and hyperplastic candidosis was not detected.The incidence was related to the degree of immune suppression and HIV viral load.
