中华口腔医学杂志
中華口腔醫學雜誌
중화구강의학잡지
Chinese Journal of Stomatology
2014年
8期
459-463
,共5页
雍翔智%蒋兰岚%卢祥婵%刘伟%吴念宁%陶人川
雍翔智%蔣蘭嵐%盧祥嬋%劉偉%吳唸寧%陶人川
옹상지%장란람%로상선%류위%오념저%도인천
获得性免疫缺陷综合征%人免疫缺陷病毒%念珠菌病,口腔%白斑,毛状%口腔表征
穫得性免疫缺陷綜閤徵%人免疫缺陷病毒%唸珠菌病,口腔%白斑,毛狀%口腔錶徵
획득성면역결함종합정%인면역결함병독%념주균병,구강%백반,모상%구강표정
Acquired immunodeficiency syndrome%Human immunodeficiency virus%Candidiasis,oral%Leukoplakia,hairy%Oral lesions
目的 分析人免疫缺陷病毒(human immunodeficiency virus,HIV)感染及获得性免疫缺陷综合征(acquired immune deficiency syndrome,AIDS)患者的常见口腔病损,提高口腔医师对HIV/AIDS早期临床表现的诊断能力.方法 对127例确诊的HIV/AIDS患者进行病史采集及口腔黏膜健康状况检查和分类,同时取患者外周静脉血,采用流式细胞技术检测CD4T淋巴细胞计数.依据美国疾病控制与预防中心颁布的分级标准将患者分为HIV携带组(42例)和AIDS组(85例),对两组患者口腔表征与系统疾病的关系及口腔表征在两组间的患病率差异采用卡方检验,对口腔表征与CD4T细胞计数的相关性采用Spearman相关分析,以双侧P＜0.05为差异有统计学意义.结果 HIV/AIDS常见的口腔表征中口腔念珠菌病占40.2％ (51/127),毛状白斑占18.9％(24/127).口腔表征的出现与系统疾病患病无显著相关性(x2=0.718,P=0.397),两组患者的口腔表征总体间及口腔念珠菌病患病率间差异均有统计学意义(x2=7.684,P=0.006;x2=14.410,P＜0.001),两组患者毛状白斑的患病率差异无统计学意义(x2=0.988,P=0.320).口腔表征及口腔念珠菌病的患病与CD4T细胞计数均呈负相关(r=-0.243,P=0.006;r=-0.265,P=0.003),毛状白斑的患病与CD4T细胞计数无相关性(r=0.019,P=0.835).结论 HIV/AIDS患者在系统疾病出现前即可出现明显的口腔表征,并以口腔念珠菌病、毛状白斑最常见;口腔表征的出现与全身系统疾病发病无明显相关关系,但口腔表征可作为观察HIV/AIDS进展的一个重要指标.
目的 分析人免疫缺陷病毒(human immunodeficiency virus,HIV)感染及穫得性免疫缺陷綜閤徵(acquired immune deficiency syndrome,AIDS)患者的常見口腔病損,提高口腔醫師對HIV/AIDS早期臨床錶現的診斷能力.方法 對127例確診的HIV/AIDS患者進行病史採集及口腔黏膜健康狀況檢查和分類,同時取患者外週靜脈血,採用流式細胞技術檢測CD4T淋巴細胞計數.依據美國疾病控製與預防中心頒佈的分級標準將患者分為HIV攜帶組(42例)和AIDS組(85例),對兩組患者口腔錶徵與繫統疾病的關繫及口腔錶徵在兩組間的患病率差異採用卡方檢驗,對口腔錶徵與CD4T細胞計數的相關性採用Spearman相關分析,以雙側P＜0.05為差異有統計學意義.結果 HIV/AIDS常見的口腔錶徵中口腔唸珠菌病佔40.2％ (51/127),毛狀白斑佔18.9％(24/127).口腔錶徵的齣現與繫統疾病患病無顯著相關性(x2=0.718,P=0.397),兩組患者的口腔錶徵總體間及口腔唸珠菌病患病率間差異均有統計學意義(x2=7.684,P=0.006;x2=14.410,P＜0.001),兩組患者毛狀白斑的患病率差異無統計學意義(x2=0.988,P=0.320).口腔錶徵及口腔唸珠菌病的患病與CD4T細胞計數均呈負相關(r=-0.243,P=0.006;r=-0.265,P=0.003),毛狀白斑的患病與CD4T細胞計數無相關性(r=0.019,P=0.835).結論 HIV/AIDS患者在繫統疾病齣現前即可齣現明顯的口腔錶徵,併以口腔唸珠菌病、毛狀白斑最常見;口腔錶徵的齣現與全身繫統疾病髮病無明顯相關關繫,但口腔錶徵可作為觀察HIV/AIDS進展的一箇重要指標.
목적 분석인면역결함병독(human immunodeficiency virus,HIV)감염급획득성면역결함종합정(acquired immune deficiency syndrome,AIDS)환자적상견구강병손,제고구강의사대HIV/AIDS조기림상표현적진단능력.방법 대127례학진적HIV/AIDS환자진행병사채집급구강점막건강상황검사화분류,동시취환자외주정맥혈,채용류식세포기술검측CD4T림파세포계수.의거미국질병공제여예방중심반포적분급표준장환자분위HIV휴대조(42례)화AIDS조(85례),대량조환자구강표정여계통질병적관계급구강표정재량조간적환병솔차이채용잡방검험,대구강표정여CD4T세포계수적상관성채용Spearman상관분석,이쌍측P＜0.05위차이유통계학의의.결과 HIV/AIDS상견적구강표정중구강념주균병점40.2％ (51/127),모상백반점18.9％(24/127).구강표정적출현여계통질병환병무현저상관성(x2=0.718,P=0.397),량조환자적구강표정총체간급구강념주균병환병솔간차이균유통계학의의(x2=7.684,P=0.006;x2=14.410,P＜0.001),량조환자모상백반적환병솔차이무통계학의의(x2=0.988,P=0.320).구강표정급구강념주균병적환병여CD4T세포계수균정부상관(r=-0.243,P=0.006;r=-0.265,P=0.003),모상백반적환병여CD4T세포계수무상관성(r=0.019,P=0.835).결론 HIV/AIDS환자재계통질병출현전즉가출현명현적구강표정,병이구강념주균병、모상백반최상견;구강표정적출현여전신계통질병발병무명현상관관계,단구강표정가작위관찰HIV/AIDS진전적일개중요지표.
Objective To investigate the features of oral lesions in patients with human immunodeficiency virus infection/acquired immunodeficiency syndrome(HIV/AIDS).Methods A total of 127 HIV-seropositive patients were interviewed for health information and examined for their HIV-related oral lesions according to the EC Clearing House Criteria on Oral Problems related to HIV-Infection (1992).The examinations were conducted by dental specialist and HIV specialist.The CD4 T cell count in peripheral blood of the patients was tested by flow cytometry.The patients were divided into HIV-infected group(42) and AIDS group(85) according to CDC Classification System for HIV-Infected Adults and Adolescents(revised in 1993).Chi-square test was used to test the relationship between systemic disease and oral lesions,and the difference of the prevalence of oral lesions between the two groups.Results Among the 127 patients,oral candidiasis(51/127),oral hairy leukoplakia(24/127) were common oral manifestation.There was no relationship between the oral manifestation and systemic disease(P=0.397).The occurrence of oral lesions and oral candidiasis was significantly different between the two groups(x2=7.684,P=0.006; x2=14.410,P＜0.001).The CD4 count was related to the prevalence of oral lesions (P==0.006) and oral candidasis (P=0.003).Conclusions Most oral lesions appeared before the appearance of systemic disease.Oral candidiasis and oral hairy leukoplakia were the most common lesions.Oral lesions had no relationship with systemic disease but could be still an indicator for disease progress.
