中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2013年
6期
347-350
,共4页
胡洁%张卫英%何松哲%陈岳明%余道军
鬍潔%張衛英%何鬆哲%陳嶽明%餘道軍
호길%장위영%하송철%진악명%여도군
呼吸道感染%儿童%流行病学%支原体,肺炎%EB病毒%巨细胞病毒
呼吸道感染%兒童%流行病學%支原體,肺炎%EB病毒%巨細胞病毒
호흡도감염%인동%류행병학%지원체,폐염%EB병독%거세포병독
Respiratory tract infections%Child%Epidemiology%Mycoplasma pneumoniae%Epstein-Barr virus%Cytomegalovirus
目的 探讨杭州地区不同年龄段儿童急性上呼吸道感染肺炎支原体、EB病毒和巨细胞病毒检出情况和季节流行特点.方法 采集2011年1月至2012年12月杭州市第一人民医院5942例急性上呼吸道感染患儿的咽拭子和痰液样本,采用荧光定量PCR方法检测肺炎支原体(Mycoplasma pneumoniae,MP)、EB病毒(Epstein-Barr virus)、巨细胞病毒(Cytomegaoviyns,CMV),并采用x2检验对不同年龄段患儿病原体的检出率和季节流行变化进行统计学分析.结果 5942例急性上呼吸道感染患儿中,MP、EB病毒、CMV的检出率分别为29.91％(1777/5942),22.92％(1362/5942),8.55％(508/5942),其中556例(9.36％)患儿同时检出两种或两种以上病原体.各年龄段MP检出率差异有统计学意义(x2=113,P=0.000),其中＞6岁年龄组的MP检出率最高(448/1012,44.36％);EB病毒在0～1岁患儿中检出率最低(7.00％),与其他三个年龄段相比差异具有统计学意义(x2=167,181和187,P=0.000);0～1岁患儿中CMV检出率最高(23.78％).各月份MP检出率差异具有统计学意义(x2=208和211,P=0.000),7、8月份达高峰.结论 杭州地区儿童急性上呼吸道感染非典型病原体以MP为主,MP与EB病毒的混合感染也多见.MP和EB病毒的感染率随年龄的上升而升高,而CMV则以0～1岁的婴儿多见.MP感染率在冬春季节较低,夏秋季节增高.
目的 探討杭州地區不同年齡段兒童急性上呼吸道感染肺炎支原體、EB病毒和巨細胞病毒檢齣情況和季節流行特點.方法 採集2011年1月至2012年12月杭州市第一人民醫院5942例急性上呼吸道感染患兒的嚥拭子和痰液樣本,採用熒光定量PCR方法檢測肺炎支原體(Mycoplasma pneumoniae,MP)、EB病毒(Epstein-Barr virus)、巨細胞病毒(Cytomegaoviyns,CMV),併採用x2檢驗對不同年齡段患兒病原體的檢齣率和季節流行變化進行統計學分析.結果 5942例急性上呼吸道感染患兒中,MP、EB病毒、CMV的檢齣率分彆為29.91％(1777/5942),22.92％(1362/5942),8.55％(508/5942),其中556例(9.36％)患兒同時檢齣兩種或兩種以上病原體.各年齡段MP檢齣率差異有統計學意義(x2=113,P=0.000),其中＞6歲年齡組的MP檢齣率最高(448/1012,44.36％);EB病毒在0～1歲患兒中檢齣率最低(7.00％),與其他三箇年齡段相比差異具有統計學意義(x2=167,181和187,P=0.000);0～1歲患兒中CMV檢齣率最高(23.78％).各月份MP檢齣率差異具有統計學意義(x2=208和211,P=0.000),7、8月份達高峰.結論 杭州地區兒童急性上呼吸道感染非典型病原體以MP為主,MP與EB病毒的混閤感染也多見.MP和EB病毒的感染率隨年齡的上升而升高,而CMV則以0～1歲的嬰兒多見.MP感染率在鼕春季節較低,夏鞦季節增高.
목적 탐토항주지구불동년령단인동급성상호흡도감염폐염지원체、EB병독화거세포병독검출정황화계절류행특점.방법 채집2011년1월지2012년12월항주시제일인민의원5942례급성상호흡도감염환인적인식자화담액양본,채용형광정량PCR방법검측폐염지원체(Mycoplasma pneumoniae,MP)、EB병독(Epstein-Barr virus)、거세포병독(Cytomegaoviyns,CMV),병채용x2검험대불동년령단환인병원체적검출솔화계절류행변화진행통계학분석.결과 5942례급성상호흡도감염환인중,MP、EB병독、CMV적검출솔분별위29.91％(1777/5942),22.92％(1362/5942),8.55％(508/5942),기중556례(9.36％)환인동시검출량충혹량충이상병원체.각년령단MP검출솔차이유통계학의의(x2=113,P=0.000),기중＞6세년령조적MP검출솔최고(448/1012,44.36％);EB병독재0～1세환인중검출솔최저(7.00％),여기타삼개년령단상비차이구유통계학의의(x2=167,181화187,P=0.000);0～1세환인중CMV검출솔최고(23.78％).각월빈MP검출솔차이구유통계학의의(x2=208화211,P=0.000),7、8월빈체고봉.결론 항주지구인동급성상호흡도감염비전형병원체이MP위주,MP여EB병독적혼합감염야다견.MP화EB병독적감염솔수년령적상승이승고,이CMV칙이0～1세적영인다견.MP감염솔재동춘계절교저,하추계절증고.
Objective To investigate the epidemiological characteristics of mycoplasma pneumoniae (MP),Epstein-Barr virus (EB virus) and cytomegalovirus (CMV) infection in children with acute upper respiratory tract infections in Hangzhou.Methods Throat swabs and sputum samples were collected from 5942 children with acute upper respiratory tract infections in Hangzhou First People's Hospital during January 2011 and December 2012.MP,EB virus and CMV were detected using quantitative PCR.The distribution and seasonal changes of the above pathogens in children of different ages were analyzed using Chi-square tests.Results MP,EB virus and CMV were positive in 29.91％ (1777/5942),22.92％ (1362/5942) and 8.55％ (508/5942) children,respectively.Mixed infections were found in 556 (9.36％) children.The positive rates of MP varied among different age groups (x2 =113,P =0.000),and the highest one was detected in children ＞ 6-year old (448/1012,44.36％).EB virus infection was rare in age group 0-1 year,and the positive rate was of statistical difference from those in other age groups (x2 =167,181 and 187,P =0.000).The highest positive rate of CMV (23.78％) was found in children aged 0-1 year old.The positive rates of MP varied in different months of the year (x2 =208 and 211,P =0.000),and the highest positive rate was found in July and August.Conclusion The predominant pathogen of acute upper respiratory tract infection in children is MP in Hangzhou,and MP plus EB virus infection is common,particularly in older children;while CMV infection more likely occures in 0-1 year old babies,and usually in summer.
